Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

@monsoon0 Those genetic markers are FAR from a crystal ball... here's the GWAS paper where their markers came from: https://t.co/AsGN0xkxxw https://t.co/40AyGkxyof

Source 3: https://t.co/8CNndqqStH

@legobearski @ent3c @charlesmurray https://t.co/sgzesSLbHR

RT @PGCgenetics: Reanalysis of CNVs across 11 published studies in ADHD showed enrichment of genes & networks across species. Novel candida…

Reanalysis of CNVs across 11 published studies in ADHD showed enrichment of genes & networks across species. Novel candidate genes for ADHD through integration across species and variant types. https://t.co/15lScL63IY

How come we never hear about this now well-established result from proponents of GWAS? Esp when they're writing these papers advocating for how some GWAS predict education so very well... That your scores are terrible for non-Whites seems like a rather fun

@jstevewhite @amiguello1 @Pseudobadger @SarahGrynpas @and_furiouser @karischoonbee @jessesingal No, GWAS identifies genes that have association with a particular phenotype. It is this collection of genes that is used in the paper (identified in Lee et al.

@BlackMa30578734 Une des études citées (la plus grosse en 2018 selon l'article) trouve que “les scores polygéniques expliquent 11-13% de la variance dans le succès scolaire et 7-10% de la variance dans les performance cognitives”. (Paye ton “hérédité bien

@AnarchoBoog @warren__terra @CarlSagan42O @AppositeRiposte @KateCagle @nycsouthpaw See figure 4 https://t.co/vgd8pT8s0M

@ProvNero @DrunkenPanda42 @Systemrelevant0 Mal einige Quellen dazu: https://t.co/ipVuzduoK5 https://t.co/05FoVA883Z https://t.co/QXmI9Brmld Zum Teil wurden auch schon Zusammenhänge zu spezifischen Genen hergestellt (jedoch nur kleinere Anteile): https://t.

@veroyeet @TedJasper1 @NBCNews https://t.co/7wtaJmW0TD There are studies coming out now showing that Europeans are much more likely than Africans to possess certain genes that predict intelligence. It's why there's been such a push to ban this kind of rese

12/25 As a result, our new PGS contains information about income over and above that contained in the PGS for educational attainment from our previous study in N~1.1mio individuals (see Table 4 and tweet 10 in this thread)... https://t.co/i7zcqXnsYC

7/25 26 of our loci were previously found to be associated with average household income https://t.co/p1Kox4Y7qB and 31 with educational attainment https://t.co/i7zcqXnsYC. Thus, the genetic architectures of different measures of socioeconomic attainment a

@charlesmurray EA herit (Silv ea 2020) is crit bec GWAS (Lee ea 2018, Dunkel ea 2019, Piffer 2019/20) req large SS and more direct/stand tests of GI are not curr ava at scale https://t.co/oaBq1FRfuZ https://t.co/FB2yUBidkn https://t.co/8NQLBi6FlL https://

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

@Thinking__T @Bioliberalism @symmo1969 @a_centrism @Parapraxis1980 @patrickamon @sapinker @Quillette sorry link for JJ Lee et al. was not correct, try this link https://t.co/EegwK9CREj

@Thinking__T @Bioliberalism @symmo1969 @a_centrism @Parapraxis1980 @patrickamon @sapinker @Quillette Some of the genomic DNA variation that influences IQ and educational attainment was identified by JJ Lee et al. https://t.co/g09rS6Or3V The polygenic score

@DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been determined by JJ Lee et al. https://t.co/EegwK9CREj These DNA variants show the ethnoracial group variation that is predicted by th

@MMMalign Polygenic scores are based on the discovery study from Lee et al (2018). https://t.co/GpiKvL1trE

@primalpoly @ent3c The question of population differences in measurable IQ (or more crit trait GI) has not been "litigated". The research is only just getting started. Piffer (2019) - https://t.co/8NQLBi6FlL Dunkel et al. (2019) - https://t.co/IToB7Cengt

@SecretBaboon @benoit_cambron @a_centrism @EPoe187 > Omnigenic model = all genes involved in everything, which undermines your own GWAS tissue correlations which have lead to nothing. Lmao. You could look at high probability of causality SNPs in supp

I'm not against GWAS. I love papers that are informative and not just a grocery list of associations. So far my favourite is SSGAC's EA3 GWAS. When you read the paper, you can easily tell that the authors know what they're talking about. https://t.co/UWeH

@izzynobre Chegou até a omitir variáveis do artigo https://t.co/wN9BXBBocZ

@Theodorez97 @izzynobre O artigo que a reportagem em https://t.co/joeRuIeJxw se baseia (https://t.co/wXor9OU6DF) também leva e consideração o ambiente e anos de escolaridade do indivíduo.

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals #InWhites https://t.co/KzZrH3X2Aj.

RT @LordGenome: @SuStenhouse Nauseating! The major hereditary component in “Ancient” families is wealth, not genes. But there is a genetic…

@SuStenhouse Nauseating! The major hereditary component in “Ancient” families is wealth, not genes. But there is a genetic component to educational achievement, this paper estimated at about 12% https://t.co/4I2Bf6BaNy

https://t.co/4DeD9gaPRB. @hsu_steve said that the supplementary material is one of the most impt reading material ever. It's too bad that so few of them are interested in the *structural biology* of these genes and how they can be affected by damage from n

@loveyou_eu @HassanHakimian 2/2 whoever wrote that article is forgetting one important thing: we are not all born alike. People differ in the amount of talent they have, and the distribution of talented individuals between population is unequal. See for

@Evolving_Moloch @JAB123421232 I'm not quite sure I get what you are saying. From what I can tell the 2018 GWAS Study from Colorado University and the database from 1000 genomes project (2008-2015) shows that the difference between groups in terms of IQ

@OmkarGV @JProtzko Some papers in behavioral genetics that might be of interest: https://t.co/8ElDRARacd https://t.co/gCHVmhorb5 Or easy intro book to IQ is "Intelligence: All that Matters?"https://t.co/tIFEnqqRgK

@JonathanKaplan @itsbirdemic This isn't hereditarian crap? https://t.co/lGv1ZZTVGo

@NicoleBarbaro Lee et al. (2018). Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment. Nature genetics, 50(8), 1112. https://t.co/FB2yUBidkn https://t.co/X6KmN0xpl4

Interesting study and a very well communicated summary of findings! Worth a read 🤓 TL;DR: (not surprising) phenotypic data i.e. parents education, parents SES or child's previous exam scores, was a better predictor of educational performance than polygeni

RT @bristimtom: We used data from @CO90s to see how well two polygenic scores for education (from https://t.co/3I2NYte4is) explained group…

We used data from @CO90s to see how well two polygenic scores for education (from https://t.co/3I2NYte4is) explained group variance and predicted individual participants' exam scores at ages 7 and 16, the first and final stages of compulsory schooling in t

@itsbirdemic How are they false? And hasn't the idea that the group differences are due to heritability been vindicated by this: https://t.co/lGv1ZZTVGo The frequency of the PGS hits in individuals was found in the linked article was found to be very

@bathwin @drjulie_b https://t.co/7i9PlAfi3I Only 7~10% of this heritability is due to the genome.

@bathwin @drjulie_b Heritability doesn't mean genetic. The environment here includes education, effect of wealth, nutrition, even the mother's nutrition. When you look at what the genome really explains, it's much lower : https://t.co/7i9PlzXHca

@davecurtis314 You argue is that it would be hard and slow, that environment matters more, and that we can't identify the relevant genes. But hard and slow doesn't mean not possible. And it seems like you're overstating the case regarding finding the gene

@Evil_Kirkecraap @Biorealism You can’t seriously believe genes have ZERO effect on cognitive ability. Among many other peer-reviewed papers: https://t.co/vgd8pT8s0M

@NickWolfinger The gap is between those that did or did not graduate from a 4-year college. Why's that a "Social Class Gap"? [Citation Needed] If you called it a "polygenic score gap", at least you'd have a citation in @nature. https://t.co/yJXHIkSPfx

China South probably means the Taishan-HK-Pearl River Delta; & BJ is capital, destination of best & brightest. China cooks the books on int’l tests and this is a key way they do it. We see their Boston not their rural WV.

RT @dbweissman: @WiringTheBrain @ent3c i'd be careful about this. with so many genes, you can get "dramatic" p-values with modest enrichmen…

@WiringTheBrain @ent3c i'd be careful about this. with so many genes, you can get "dramatic" p-values with modest enrichment. eg, https://t.co/zCV2yFjqjv, first two screenshots vs third https://t.co/cEKsGJvB3B

@DrBenNeel https://t.co/MhLyz2TcTd

In fact, I invite anyone to look through other studies of this nature, such as the Lee, “Educational Attainment’ study( https://t.co/darTuXCV1w ) or the Davies “g” study (https://t.co/6ayqaSFym6 )… 5/

@UrFreundHannah Yeah apparently we’re in the era of using GWAS to study socio-economic and social “traits”… See https://t.co/0DQOZKDEN0 & https://t.co/IigRFDc1UN

#GWAS #Educational_attainment #Heritable_trait #SNPs https://t.co/2hBcAEwSav via @Get_Chirp https://t.co/NtvabNWZKn

RT @ewanbirney: @Plinker14 @Ananyo @Biorealism @RickPhillipsFL @hsu_steve @AdamRutherford Big meta analysis here. https://t.co/j5idqfuMgm…

@Plinker14 @Ananyo @Biorealism @RickPhillipsFL @hsu_steve @AdamRutherford Big meta analysis here. https://t.co/j5idqfuMgm Good solid stuff. Only thing that you have to watch in educational attainment (and it is tricky but fascinating) is that a fair propo

RT @KirkegaardEmil: @PsychRabble @HinterhaltS @IonaItalia @SkepticReview89 @nathancofnas Re. 1: Last GWAS on education found ~1300 approx.…

@PsychRabble @HinterhaltS @IonaItalia @SkepticReview89 @nathancofnas Re. 1: Last GWAS on education found ~1300 approx. independent variants. A specific GWAS on IQ found 18 approx. independent variants. The latter study is much smaller. https://t.co/tFnzHn

@JohannesTextor @shell_ki Have you seen the screed of recent papers relating a polygenic score to years of education?? https://t.co/mqDOlIlVcS https://t.co/Mms3A6aHW4 https://t.co/nl9Pi1y1kT and loads more

@ExcludedMuddle @DrCherylllP @antonioregalado good point. 1. here are some further insights: https://t.co/JrIuPL6QH4 / https://t.co/aEe0H8RQVB 2. I´m not that sure that twin studies are the best option to study that (but may be my ignorance on the topic)

Fascinating to hear of the 'Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals' study by Lee et al (2018) & 'EduYears Polygenic' and Educational Attainment https://t.co/cMSy

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals https://t.co/HoSlVZoden via @BenPatrickWill

@shakimiki @Will_Tanner @nature https://t.co/OnTJWmb5sB

しょっぱなは、educational attainmentをゲノムで予測できるか、というチャレンジングなセッション。個人の予測は今の所難しく、古典的な予測因子にプラスする情報は少ない、というよくありがちな内容。論文を読めば情報はゲットできそうなので別のセッションへ移動。 https://t.co/e3Uq4YPcmb

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals | Nature #Genetics | #cognition #education #GWAS #inheritance #intelligence https://t.co/HR2FaXo1i7

@CalaveraSurfer

RT @AmirSariaslan: @GPledare För den intresserade: https://t.co/pKTkLPydWv

@GPledare För den intresserade: https://t.co/pKTkLPydWv

@HollyBahpullo Je suis Bioinformaticien Madame ! 😀 C est vraie qu il y a des maladies heritaires lie au chromosomeX, mais la majorite de l influence genetique sur l intelligence est lie a l autosome. Sur un echantillon de 1 million... https://t.co/tx6w3Xc3

@C_Kavanagh @Quillette The numbers are creeping up constantly, and explaining 10% of the variance is significant. https://t.co/U7bgNKiIO3

RT @UnsilencedSci: @AynMarx666 @nprfreshair @charleskingdc https://t.co/QBexuw64C6 https://t.co/tP0L03P5KN

@AynMarx666 @nprfreshair @charleskingdc https://t.co/QBexuw64C6 https://t.co/tP0L03P5KN

@PsychRabble @nathancofnas @SkepticReview89 @sarahbraasch1 @mikedennymike @C_Kavanagh @holzprueghel @ImHardcory @EPoe187 @BenWinegard @PamelaParesky @dunaevtimur @amyalkon @A_N_Pathy @Jon_StewartMill @minzlicht @yorl @phl43 @ArthurCDent @jonatanpallesen We

Re cooperation with biologists in social-science genetics: This is happening all the time and it's one of the reasons the most important papers in the field have dozens or hundreds of coauthors, e.g. https://t.co/XWVhj9lYOA

@CapitalismL @RussianBot88 @StefanMolyneux Four even when significant results are found, effects are really lame, for example using educational attrition as an IQ proxy, in the biggest GWAS study to the date, at most 11% explained https://t.co/t3nuUEYgN8

@stianchrister @clairlemon @nntaleb @Quillette Hey buddy, you are out of date, recent GWAS papers on genetics of cognitive ability and other traits have huge n's. E.g. see JJ Lee et al famous 2018 paper on genes involved in educational attainment, n = 1.

No se será un sesgo algoritmico, pro parece haber un resurgimiento de genética y biología social, en lógica de "Nature First", pero algunos omiten casualmente que justamente cuando usamos los genes para estimar fenomenos sociales, efectos son marginales h

@rjhaier @charlesmurray I mean this https://t.co/t3nuUEYgN8

@AnnaMinasy @APeichl @ifo_Institut @FuestClemens @PaulHufe @Weishaar_Daniel @jecacarpediem @CESifoGroup @LMU_Muenchen @ifo_Bildung The PGS come from a genome-wide association study. We use the PGS from the following study: https://t.co/sY8ZSSqEJg

Sorry guys, no special X chromosome magic in GWASs. https://t.co/IO7th4vxOv https://t.co/TLJYBBbimE

@UnsilencedSci @charlesmurray Nah. GWASs that included X so far have found it to be less important relative to size than autosomes. https://t.co/IO7th4vxOv https://t.co/c0EiRbzQMr

Or in this 1.1 million population wide genetic study of education attainment, which would be at least as relevant than IQ, indeed more: /7 https://t.co/5oRWauEedl

https://t.co/nRVD6brbgv

@joftius @kenklippenstein @kph3k The polygenic score data in Harden's paper is based on the Lee et al. 2018 paper which has already shown to be highly replicable and in recent months is taking the social science world by storm. Read about it before you loo

@amarlevine @hbdchick There's a fair bit on differences by genetic ancestry groups: https://t.co/4jecm0tvz2, https://t.co/0AwH0EIL2J, https://t.co/V4FwOeonqh. Also https://t.co/J93tpu1S7G show big difference for the education score across groups.

We used data from @CO90s to see how well two polygenic scores for education (based on https://t.co/J93tpu1S7G using different thresholds) predicted the ALSPAC participants' exam scores at ages 7 and 16, the first and final stages of compulsory schooling in

@k_isjm この論文、sociogenomicsでは今後よく引用されると思うんですけど、著者79人（含機関）なんですよね。https://t.co/BcAkriJ9O5

@theother_95 Perhaps you can accept compliments for creating a good nurturing environment for your children, i.e. genetic nurture (though that's still due to your genes...) https://t.co/6fTZ4iE22Q https://t.co/JUjLECdOaY

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. - PubMed - NCBI https://t.co/JsDVE0bdJD

@AleksiRaudasoja @ivanpuopolo @EliasAarnio @Jussi7 @tutamAW @TomimPA @jmkorhonen @IhisTeemu @KangasAnni @JiiPeePuro @JoonasKiviranta @Minnastiina @MikkolaHarry Tämä tuli ulos viime kesänä. Replikoi aiemmat yhteydet ja löysi tuhottomasti lisää. https://t.c

@1080pno Er flere måter å gjøre det på, feks tvillingstudier. Man kan nå også forklare stadig mer av varians ved GWAS (link). Tester trenger ikke være perfekte for å være nyttige (poenget mitt om IQ). Det er en større feil å utelate ting man vet at forklar

@ike_og_ike と思うじゃないですか？それが教育年数はめっちゃ（11–13%）説明するんですよね笑 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals https://t.co/BcAkriJ9O5

@NicoleMMcNeil @kph3k @NYDailyNews Their results also had poor performance in non-europeans which means PRS aren't even generalizable. They also couldn't adequately control for parental nurture in their study. I'd take household income than some random SNP

@arnelswartz https://t.co/et0vNzzu2c https://t.co/1GHqZQAZ9l https://t.co/MZJmtN8WO6 https://t.co/jSQrmbpvLj https://t.co/cJaDLoNEU8

@sallybhunt @freetime_rifle Is statistics a social construct? https://t.co/et0vNzzu2c https://t.co/1GHqZQAZ9l https://t.co/MZJmtN8WO6 https://t.co/jSQrmbpvLj https://t.co/cJaDLoNEU8

@postdiscipline @Arrianna_Planey @prof_goldberg Going back to the latest education attainment gwas ( from which I guess the variants and their effect sizes were retrieve) https://t.co/0rMZeWN4L2 People should read it carefully, It turns out when they m

@kareem_carr @boback @kph3k @cecilejanssens Should be point out that in the GWAS from which the variants are retrieve make this clear https://t.co/0rMZeWN4L2 ( discussion section) The effect sizes of the variants are not concordant when you restrict the a

@joftius @ewanbirney @bendomingue @Danbelsky @michelnivard @tuckerdrob @MarghMalanchini @jasondboardman yes possible, although results from within-family sibling or DZ twin comparisons are pretty good evidence that this isn't the whole story. https://t.co/

@iskander @bendomingue @Danbelsky @michelnivard @tuckerdrob @MarghMalanchini @jasondboardman based on previous GWAS https://t.co/enwhyECb7M

(Data for the blue line from this paper on NLSY data: https://t.co/vZXMlgeqZg, Data for the red line from this paper in Add Health: https://t.co/enwhyECb7M)

New from #The_MRC https://t.co/kPsTyWOWtC Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment