@bathwin @drjulie_b Heritability doesn't mean genetic. The environment here includes education, effect of wealth, nutrition, even the mother's nutrition. When you look at what the genome really explains, it's much lower : https://t.co/7i9PlzXHca
@davecurtis314 You argue is that it would be hard and slow, that environment matters more, and that we can't identify the relevant genes. But hard and slow doesn't mean not possible. And it seems like you're overstating the case regarding finding the gene
@Evil_Kirkecraap @Biorealism You can’t seriously believe genes have ZERO effect on cognitive ability. Among many other peer-reviewed papers: https://t.co/vgd8pT8s0M
@NickWolfinger The gap is between those that did or did not graduate from a 4-year college. Why's that a "Social Class Gap"? [Citation Needed] If you called it a "polygenic score gap", at least you'd have a citation in @nature. https://t.co/yJXHIkSPfx
China South probably means the Taishan-HK-Pearl River Delta; & BJ is capital, destination of best & brightest. China cooks the books on int’l tests and this is a key way they do it. We see their Boston not their rural WV.
RT @dbweissman: @WiringTheBrain @ent3c i'd be careful about this. with so many genes, you can get "dramatic" p-values with modest enrichmen…
@WiringTheBrain @ent3c i'd be careful about this. with so many genes, you can get "dramatic" p-values with modest enrichment. eg, https://t.co/zCV2yFjqjv, first two screenshots vs third https://t.co/cEKsGJvB3B
In fact, I invite anyone to look through other studies of this nature, such as the Lee, “Educational Attainment’ study( https://t.co/darTuXCV1w ) or the Davies “g” study (https://t.co/6ayqaSFym6 )… 5/
@js_thrill Also see: https://t.co/MLzkw4RknN But insofar as you think my claim is misguided, imagine a possible world where humans attain perfect equality of opportunity in the sense that we eliminate the effects of zip codes, parental income, etc. on var
@HAAANBIN There is this blog post about pop. differences in IQ related genes: https://t.co/N6QhVHK1HA As well as 2 frequently cited studies by race realists about education attainment related genes: Piffer 2019 and Lee et al. 2018 https://t.co/BgN8Qnt8o
@UrFreundHannah Yeah apparently we’re in the era of using GWAS to study socio-economic and social “traits”… See https://t.co/0DQOZKDEN0 & https://t.co/IigRFDc1UN
RT @ewanbirney: @Plinker14 @Ananyo @Biorealism @RickPhillipsFL @hsu_steve @AdamRutherford Big meta analysis here. https://t.co/j5idqfuMgm…
@Plinker14 @Ananyo @Biorealism @RickPhillipsFL @hsu_steve @AdamRutherford Big meta analysis here. https://t.co/j5idqfuMgm Good solid stuff. Only thing that you have to watch in educational attainment (and it is tricky but fascinating) is that a fair propo
RT @KirkegaardEmil: @PsychRabble @HinterhaltS @IonaItalia @SkepticReview89 @nathancofnas Re. 1: Last GWAS on education found ~1300 approx.…
@PsychRabble @HinterhaltS @IonaItalia @SkepticReview89 @nathancofnas Re. 1: Last GWAS on education found ~1300 approx. independent variants. A specific GWAS on IQ found 18 approx. independent variants. The latter study is much smaller. https://t.co/tFnzHn
@JohannesTextor @shell_ki Have you seen the screed of recent papers relating a polygenic score to years of education?? https://t.co/mqDOlIlVcS https://t.co/Mms3A6aHW4 https://t.co/nl9Pi1y1kT and loads more
@ExcludedMuddle @DrCherylllP @antonioregalado good point. 1. here are some further insights: https://t.co/JrIuPL6QH4 / https://t.co/aEe0H8RQVB 2. I´m not that sure that twin studies are the best option to study that (but may be my ignorance on the topic)
Fascinating to hear of the 'Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals' study by Lee et al (2018) & 'EduYears Polygenic' and Educational Attainment https://t.co/cMSy
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals https://t.co/HoSlVZoden via @BenPatrickWill
しょっぱなは、educational attainmentをゲノムで予測できるか、というチャレンジングなセッション。個人の予測は今の所難しく、古典的な予測因子にプラスする情報は少ない、というよくありがちな内容。論文を読めば情報はゲットできそうなので別のセッションへ移動。 https://t.co/e3Uq4YPcmb
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals | Nature #Genetics | #cognition #education #GWAS #inheritance #intelligence https://t.co/HR2FaXo1i7
@CalaveraSurfer
RT @AmirSariaslan: @GPledare För den intresserade: https://t.co/pKTkLPydWv
@GPledare För den intresserade: https://t.co/pKTkLPydWv
@HollyBahpullo Je suis Bioinformaticien Madame ! 😀 C est vraie qu il y a des maladies heritaires lie au chromosomeX, mais la majorite de l influence genetique sur l intelligence est lie a l autosome. Sur un echantillon de 1 million... https://t.co/tx6w3Xc3
@C_Kavanagh @Quillette The numbers are creeping up constantly, and explaining 10% of the variance is significant. https://t.co/U7bgNKiIO3
Re cooperation with biologists in social-science genetics: This is happening all the time and it's one of the reasons the most important papers in the field have dozens or hundreds of coauthors, e.g. https://t.co/XWVhj9lYOA
@CapitalismL @RussianBot88 @StefanMolyneux Four even when significant results are found, effects are really lame, for example using educational attrition as an IQ proxy, in the biggest GWAS study to the date, at most 11% explained https://t.co/t3nuUEYgN8
@stianchrister @clairlemon @nntaleb @Quillette Hey buddy, you are out of date, recent GWAS papers on genetics of cognitive ability and other traits have huge n's. E.g. see JJ Lee et al famous 2018 paper on genes involved in educational attainment, n = 1.
No se será un sesgo algoritmico, pro parece haber un resurgimiento de genética y biología social, en lógica de "Nature First", pero algunos omiten casualmente que justamente cuando usamos los genes para estimar fenomenos sociales, efectos son marginales h
@rjhaier @charlesmurray I mean this https://t.co/t3nuUEYgN8
@AnnaMinasy @APeichl @ifo_Institut @FuestClemens @PaulHufe @Weishaar_Daniel @jecacarpediem @CESifoGroup @LMU_Muenchen @ifo_Bildung The PGS come from a genome-wide association study. We use the PGS from the following study: https://t.co/sY8ZSSqEJg
Sorry guys, no special X chromosome magic in GWASs. https://t.co/IO7th4vxOv https://t.co/TLJYBBbimE
@UnsilencedSci @charlesmurray Nah. GWASs that included X so far have found it to be less important relative to size than autosomes. https://t.co/IO7th4vxOv https://t.co/c0EiRbzQMr
Or in this 1.1 million population wide genetic study of education attainment, which would be at least as relevant than IQ, indeed more: /7 https://t.co/5oRWauEedl
@joftius @kenklippenstein @kph3k The polygenic score data in Harden's paper is based on the Lee et al. 2018 paper which has already shown to be highly replicable and in recent months is taking the social science world by storm. Read about it before you loo
@AndrewYang Behavior genetics is really interesting stuff. Educational attainment also turns out to be partially linked to genes. https://t.co/MLzkw4RknN Very relevant to how we think of equality of opportunity!
@amarlevine @hbdchick There's a fair bit on differences by genetic ancestry groups: https://t.co/4jecm0tvz2, https://t.co/0AwH0EIL2J, https://t.co/V4FwOeonqh. Also https://t.co/J93tpu1S7G show big difference for the education score across groups.
We used data from @CO90s to see how well two polygenic scores for education (based on https://t.co/J93tpu1S7G using different thresholds) predicted the ALSPAC participants' exam scores at ages 7 and 16, the first and final stages of compulsory schooling in
@k_isjm この論文、sociogenomicsでは今後よく引用されると思うんですけど、著者79人（含機関）なんですよね。https://t.co/BcAkriJ9O5
@theother_95 Perhaps you can accept compliments for creating a good nurturing environment for your children, i.e. genetic nurture (though that's still due to your genes...) https://t.co/6fTZ4iE22Q https://t.co/JUjLECdOaY
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. - PubMed - NCBI https://t.co/JsDVE0bdJD
@AleksiRaudasoja @ivanpuopolo @EliasAarnio @Jussi7 @tutamAW @TomimPA @jmkorhonen @IhisTeemu @KangasAnni @JiiPeePuro @JoonasKiviranta @Minnastiina @MikkolaHarry Tämä tuli ulos viime kesänä. Replikoi aiemmat yhteydet ja löysi tuhottomasti lisää. https://t.c
@1080pno Er flere måter å gjøre det på, feks tvillingstudier. Man kan nå også forklare stadig mer av varians ved GWAS (link). Tester trenger ikke være perfekte for å være nyttige (poenget mitt om IQ). Det er en større feil å utelate ting man vet at forklar
@ike_og_ike と思うじゃないですか？それが教育年数はめっちゃ（11–13%）説明するんですよね笑 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals https://t.co/BcAkriJ9O5
RT @ChristaCaggiano: @NicoleMMcNeil @kph3k @NYDailyNews Their results also had poor performance in non-europeans which means PRS aren't eve…
@NicoleMMcNeil @kph3k @NYDailyNews Their results also had poor performance in non-europeans which means PRS aren't even generalizable. They also couldn't adequately control for parental nurture in their study. I'd take household income than some random SNP
@sallybhunt @freetime_rifle Is statistics a social construct? https://t.co/et0vNzzu2c https://t.co/1GHqZQAZ9l https://t.co/MZJmtN8WO6 https://t.co/jSQrmbpvLj https://t.co/cJaDLoNEU8
@postdiscipline @Arrianna_Planey @prof_goldberg Going back to the latest education attainment gwas ( from which I guess the variants and their effect sizes were retrieve) https://t.co/0rMZeWN4L2 People should read it carefully, It turns out when they m
@kareem_carr @boback @kph3k @cecilejanssens Should be point out that in the GWAS from which the variants are retrieve make this clear https://t.co/0rMZeWN4L2 ( discussion section) The effect sizes of the variants are not concordant when you restrict the a
@joftius @ewanbirney @bendomingue @Danbelsky @michelnivard @tuckerdrob @MarghMalanchini @jasondboardman yes possible, although results from within-family sibling or DZ twin comparisons are pretty good evidence that this isn't the whole story. https://t.co/
@iskander @bendomingue @Danbelsky @michelnivard @tuckerdrob @MarghMalanchini @jasondboardman based on previous GWAS https://t.co/enwhyECb7M
(Data for the blue line from this paper on NLSY data: https://t.co/vZXMlgeqZg, Data for the red line from this paper in Add Health: https://t.co/enwhyECb7M)
New from #The_MRC https://t.co/kPsTyWOWtC Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment
New from #ERC_Research https://t.co/kPsTyWOWtC Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment
@NickWolfinger Step 1, download data from Lee JJ et al 2018 https://t.co/EegwK9CREj … Step 2. enter MTAG-EA3 data into GADGET site for displaying ethnoracial group variation in 1000 genome data https://t.co/1KcZ7dOclu
RT @RoyAFrye1: @ngmcclernan @amy_harmon @gcochran99 @thessgac @DPosthu Step 1, download data from Lee JJ et al 2018 https://t.co/EegwK9CREj…
@ngmcclernan @amy_harmon @gcochran99 @thessgac @DPosthu Step 1, download data from Lee JJ et al 2018 https://t.co/EegwK9CREj Step 2. enter MTAG-EA3 data into GADGET site for displaying ethnoracial group variation in 1000 genome data https://t.co/1KcZ7dOcl
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
@Apestatic @Race__Realist @akarlin88 Things are moving along https://t.co/jcfrZTcofo
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
@sonyaellenmann @hamandcheese and more importantly https://t.co/pYCZcpEk01
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
For me the true question is not whether the CRISPR chinese twins are smarter because of the HIV immunity mutation but whether Jianku He was stupid enough to believe they would be and whether that influenced his weird choice of phenotype to engineer
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
RT @razibkhan: this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s…
this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s. never found anything. 2) recent work with 1 million samples did not pick this up https://t.co/6XSn7HR6pK 3) a HUGE proportion of g
@RCownie @esotericsqrl @gcochran99 @JoeWMAGA @EPoe187 Let’s go to the literature: “[our] polygenic scores... explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance.” https://t.co/XBfyttdBEK
RT @RoyAFrye1: @CathrynTownsend @amy_harmon Polygenic predictors (DNA differences data) from this recent study when applied to ethnoracial…
@CathrynTownsend @amy_harmon Polygenic predictors (DNA differences data) from this recent study when applied to ethnoracial groups, totally supports the Jensenist Hereditarian theory of gene differences as the major cause for observed group differences in
@hmmmnah1 @freemonotheist @StefanMolyneux What, you mean something like this? https://t.co/UnR1SMcnZJ
@f2harrell @nilanjan10c Sure, for example this: https://t.co/bcLlGD6tq8 reports the ammount of explained phenotypic variance at different thresholds. Or https://t.co/6eDxaZAslS. In both cases this is mentioned in the abstract.
RT @gcochran99: @jpklock @844y @amy_harmon Like here. https://t.co/hjdStORvVn You're behind the times. But you don't need specific sequen…
RT @gcochran99: @jpklock @844y @amy_harmon Like here. https://t.co/hjdStORvVn You're behind the times. But you don't need specific sequen…
@jpklock @844y @amy_harmon Like here. https://t.co/hjdStORvVn You're behind the times. But you don't need specific sequences: do an admixture study.
@Apestatic @TimRooney10 @jorio1984 @nntaleb @rjhaier Stuart Ritchie, the IQ researcher, named the Lee et al. (2018) GWAS as one of his favourite papers of 2018. https://t.co/SsDt587yI0
@Apestatic @TimRooney10 @jorio1984 @nntaleb @rjhaier From here: https://t.co/wJGfomvBfo SNPs identified in the GWAS looking at over 1 million people also went into great detail. See the attached image. Go to Part 5 of the Supplementary Note in the paper:
@itsbirdemic @Simon_Whitten @polyaletheia @SimonDeDeo By the way, the GWA studies that I mention have already directly identified DNA differences accounting for 7-10% of variance in intelligence. We now have polygenic scores for educational achievement tha
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…