@CapitalismL @RussianBot88 @StefanMolyneux Four even when significant results are found, effects are really lame, for example using educational attrition as an IQ proxy, in the biggest GWAS study to the date, at most 11% explained https://t.co/t3nuUEYgN8
@stianchrister @clairlemon @nntaleb @Quillette Hey buddy, you are out of date, recent GWAS papers on genetics of cognitive ability and other traits have huge n's. E.g. see JJ Lee et al famous 2018 paper on genes involved in educational attainment, n = 1.
No se será un sesgo algoritmico, pro parece haber un resurgimiento de genética y biología social, en lógica de "Nature First", pero algunos omiten casualmente que justamente cuando usamos los genes para estimar fenomenos sociales, efectos son marginales h
@AnnaMinasy @APeichl @ifo_Institut @FuestClemens @PaulHufe @Weishaar_Daniel @jecacarpediem @CESifoGroup @LMU_Muenchen @ifo_Bildung The PGS come from a genome-wide association study. We use the PGS from the following study: https://t.co/sY8ZSSqEJg
@BakerFlan @Rongwrong_ @DialecticalA Yes. Table 13 of Lee et al.https://t.co/oxW86ek478 top 226 SNPs for cognitive ability have mean absolute effect size of 0.02 and only 30 are over 0.03. Those SNPs alone explain hardly any variance (~2% or less normally)
Or in this 1.1 million population wide genetic study of education attainment, which would be at least as relevant than IQ, indeed more: /7 https://t.co/5oRWauEedl
@joftius @kenklippenstein @kph3k The polygenic score data in Harden's paper is based on the Lee et al. 2018 paper which has already shown to be highly replicable and in recent months is taking the social science world by storm. Read about it before you loo
@AndrewYang Behavior genetics is really interesting stuff. Educational attainment also turns out to be partially linked to genes. https://t.co/MLzkw4RknN Very relevant to how we think of equality of opportunity!
@amarlevine @hbdchick There's a fair bit on differences by genetic ancestry groups: https://t.co/4jecm0tvz2, https://t.co/0AwH0EIL2J, https://t.co/V4FwOeonqh. Also https://t.co/J93tpu1S7G show big difference for the education score across groups.
We used data from @CO90s to see how well two polygenic scores for education (based on https://t.co/J93tpu1S7G using different thresholds) predicted the ALSPAC participants' exam scores at ages 7 and 16, the first and final stages of compulsory schooling in
@theother_95 Perhaps you can accept compliments for creating a good nurturing environment for your children, i.e. genetic nurture (though that's still due to your genes...) https://t.co/6fTZ4iE22Q https://t.co/JUjLECdOaY
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. - PubMed - NCBI https://t.co/JsDVE0bdJD
@AleksiRaudasoja @ivanpuopolo @EliasAarnio @Jussi7 @tutamAW @TomimPA @jmkorhonen @IhisTeemu @KangasAnni @JiiPeePuro @JoonasKiviranta @Minnastiina @MikkolaHarry Tämä tuli ulos viime kesänä. Replikoi aiemmat yhteydet ja löysi tuhottomasti lisää. https://t.c
@1080pno Er flere måter å gjøre det på, feks tvillingstudier. Man kan nå også forklare stadig mer av varians ved GWAS (link). Tester trenger ikke være perfekte for å være nyttige (poenget mitt om IQ). Det er en større feil å utelate ting man vet at forklar
@ike_og_ike と思うじゃないですか？それが教育年数はめっちゃ（11–13%）説明するんですよね笑 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals https://t.co/BcAkriJ9O5
@NicoleMMcNeil @kph3k @NYDailyNews Their results also had poor performance in non-europeans which means PRS aren't even generalizable. They also couldn't adequately control for parental nurture in their study. I'd take household income than some random SNP
@postdiscipline @Arrianna_Planey @prof_goldberg Going back to the latest education attainment gwas ( from which I guess the variants and their effect sizes were retrieve) https://t.co/0rMZeWN4L2 People should read it carefully, It turns out when they m
@kareem_carr @boback @kph3k @cecilejanssens Should be point out that in the GWAS from which the variants are retrieve make this clear https://t.co/0rMZeWN4L2 ( discussion section) The effect sizes of the variants are not concordant when you restrict the a
@joftius @ewanbirney @bendomingue @Danbelsky @michelnivard @tuckerdrob @MarghMalanchini @jasondboardman yes possible, although results from within-family sibling or DZ twin comparisons are pretty good evidence that this isn't the whole story. https://t.co/
@NickWolfinger Step 1, download data from Lee JJ et al 2018 https://t.co/EegwK9CREj … Step 2. enter MTAG-EA3 data into GADGET site for displaying ethnoracial group variation in 1000 genome data https://t.co/1KcZ7dOclu
@ngmcclernan @amy_harmon @gcochran99 @thessgac @DPosthu Step 1, download data from Lee JJ et al 2018 https://t.co/EegwK9CREj Step 2. enter MTAG-EA3 data into GADGET site for displaying ethnoracial group variation in 1000 genome data https://t.co/1KcZ7dOcl
For me the true question is not whether the CRISPR chinese twins are smarter because of the HIV immunity mutation but whether Jianku He was stupid enough to believe they would be and whether that influenced his weird choice of phenotype to engineer
@_TamaraWinter @hamandcheese There's no reason to believe it was intentional. I do HIV-related research and had never heard of this effect before, it's not widely known. Nor do I expect that it will hold true in humans. Razib had something to say on this a
this @antonioregalado piece is getting shared 1) ppl looked for big common gene variations (QTLs) for intelligence in 2000s. never found anything. 2) recent work with 1 million samples did not pick this up https://t.co/6XSn7HR6pK 3) a HUGE proportion of g
@RCownie @esotericsqrl @gcochran99 @JoeWMAGA @EPoe187 Let’s go to the literature: “[our] polygenic scores... explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance.” https://t.co/XBfyttdBEK
@CathrynTownsend @amy_harmon Polygenic predictors (DNA differences data) from this recent study when applied to ethnoracial groups, totally supports the Jensenist Hereditarian theory of gene differences as the major cause for observed group differences in
@f2harrell @nilanjan10c Sure, for example this: https://t.co/bcLlGD6tq8 reports the ammount of explained phenotypic variance at different thresholds. Or https://t.co/6eDxaZAslS. In both cases this is mentioned in the abstract.
@Apestatic @TimRooney10 @jorio1984 @nntaleb @rjhaier From here: https://t.co/wJGfomvBfo SNPs identified in the GWAS looking at over 1 million people also went into great detail. See the attached image. Go to Part 5 of the Supplementary Note in the paper:
@itsbirdemic @Simon_Whitten @polyaletheia @SimonDeDeo By the way, the GWA studies that I mention have already directly identified DNA differences accounting for 7-10% of variance in intelligence. We now have polygenic scores for educational achievement tha
RT briandavidearp: RT StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/qdCkLpUk7q), genetic nurture (https://t.co/mgWWtlpYV3), & genetic prediction of coronary artery disease (https://t.co/P2w5znr1
What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (https://t.co/NPWdKqZrs1), & genetic prediction of coronary artery disease (https://t.co/Q893FJwh9c) - it's been a pretty polygenic yea
@NoamJStein He needs to have a listen to this https://t.co/ze2Apmxb0d episode with @razibkhan and James Lee (one of the authors of this on genetics and educational attainment https://t.co/mmTxBdDQD0). Their knowledge, careful consideration of DIMENSIONALI
RT @StuartJRitchie: It's here! A genome-wide association study for educational attainment in Nature Genetics, including 1.1 million (!!!) p…