Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

→ 付していたが、彼が言及した論文のひとつは、遺伝的要因と教育達成度の間に考えられる関連性を探った『Nature Genetics』の2018年の研究である。 この論文を引用し、白人は黒人よりも遺伝的に頭が良いということを『証明』したのだが、これは論文内容とは全く違っていた」 https://t.co/kjT3MzJmfR

@charlesmurray The author of this essay, James Lee, was lead author on a very high impact paper in 2018 which showed certain DNA differences are linked to educational attainment and IQ. This study was led by a group called SSGAC. 1/ https://t.co/EegwK9DptR

@StevePittelli @AnrothanN @charlesmurray Please explain what you specifically believe is objectionable about this article and why you felt it was important for you to imply that Lee, being lead author on an article with dozens of collaborators, had some °

@JonTornada @AnrothanN @charlesmurray https://t.co/Tzd42bW4F4

参考文献 https://t.co/2C3eTN3jwZ https://t.co/kMqICwRAhl

Given these background, when the first large scale well-powered GWAS of educational attainment came out, many were surprised to find no enrichment in glial cells. https://t.co/UWeHpRwIOI https://t.co/7BQLqm0yoa

@kot8a 在学年数に相関がみられる、のやつです https://t.co/2AyBcccfMg

@BertGoldPhD @JohnNosta @westr @JonHaidt https://t.co/LVM2jCNmKC

And of course the paper cites the flagship of #GWASturbation studies the one that the Uvalde massacre's shooter has cited in his "manifesto", the "educational attainment" one https://t.co/1rClcjH6hu

Teze doslovno beskorisne. Nijedno navedeno istraživanje niti prvi tvit nemaju veze s predočenom slikom. Predočena slika također beskorisna.

@utikejt @stevcho91 @Bulkington__ Teze 1. Naslednost stečenog obrazovanja je visoka. 2. Za blagostanje jedne zemlje nije svejedno kakva je raspodela zanimanja njenog stanovništva. Deo izvora https://t.co/tT1J2z35So https://t.co/tSXc0lbavi https://t.co/Yn

@AnaYorke Žao mi je što Vas vređa kad neko piše istinu https://t.co/j00DGrmhDS https://t.co/AfmKYo3N0w

@KukurikuKokoda Pokrića mejnstrim nauke👇 https://t.co/j00DGrDkFS https://t.co/AfmKYnLDMo https://t.co/pcSIStuOU1

@Ana_neznana Sve je moguće, ali verovatnoće nisu iste. https://t.co/j00DGrmhDS https://t.co/noAx3PgYtu

RT @PaoloShirasi: SOURCES: https://t.co/zaSGXCR56o https://t.co/KbgGUeUHzh https://t.co/QmF2K28JrY https://t.co/fJOaq9OKDB

RT @PaoloShirasi: SOURCES: https://t.co/zaSGXCR56o https://t.co/KbgGUeUHzh https://t.co/QmF2K28JrY https://t.co/fJOaq9OKDB

SOURCES: https://t.co/zaSGXCR56o https://t.co/KbgGUeUHzh https://t.co/QmF2K28JrY https://t.co/fJOaq9OKDB

If more people became influenced by 1517/Thiel Fellow dropout culture, it would satiate Pachter's desire to utterly destroy the James J. Lee GWAS educational attainment paper (https://t.co/4a5dT10q0C) by abolishing the strange correlation between educatio

To the UK Biobank @uk_biobank: You might be aware the study linked here was cited as part of a rationale by a mass shooter in Buffalo, NY. I see a UKBB application organization (11425), but a study number (12512) that does not appear to exist. /1 https:/

O link da pesquisa pra quem tiver curiosidade https://t.co/pvTs9nZVct

@RobertoIGOCARD1 @LeoKitsune https://t.co/8Mfu6dDyOT o artigo completo para você.

..."Se você não tem os recursos da família, até as crianças brilhantes – aquelas naturalmente dotadas – terão que enfrentar batalhas muito difíceis”, disse Thom. “Muito potencial está sendo desperdiçado" Leia mais em: https://t.co/lfu9ijO6X6 A pesquisa:

For example https://t.co/f5mnS8lWWy

@Blinde_owl @yajrumujlo Я не биолог, знаю то, что в популярных книжках (напри. The Genetic Lottery от Harden). Группа снипов определяют будущее образование и, вероятно, интеллект. Или, например, это https://t.co/pcKCXO566G

@NPirastu @renebekkers @HermanWerfhorst @dr_appie It’s in the EA3 GWAS (https://t.co/Sh2c04FKAG), the average rg between the cohorts is like ~.72.

RT @ewanbirney: @lpachter I think the strongest ones are the Iceland series (this is one https://t.co/qMYtZ10pq7) but of course the other i…

RT @ewanbirney: @lpachter I think the strongest ones are the Iceland series (this is one https://t.co/qMYtZ10pq7) but of course the other i…

@lpachter I think the strongest ones are the Iceland series (this is one https://t.co/qMYtZ10pq7) but of course the other is the big meta-analysis (https://t.co/j5idqfuMgm)

For comparison, the genome-wide signal from an 1.1 million GWAS of educational attainment (a highly polygenic trait) explain only <4% of the phenotypic variance (first bars) https://t.co/UWeHpRwIOI https://t.co/3udQ0s6EVB

As an outsider, it strikes me that the epigenetics research agenda poses a misspecification challenge to gene-economists as the latter zero out interaction effects (by ignoring the interplay between genes and environmental factors). https://t.co/UNKVrVeoc

RT @PGCgenetics: Reanalysis of CNVs across 11 published studies in ADHD showed enrichment of genes & networks across species. We identified…

RT @PGCgenetics: Reanalysis of CNVs across 11 published studies in ADHD showed enrichment of genes & networks across species. We identified…

@FDrenos

Reanalysis of CNVs across 11 published studies in ADHD showed enrichment of genes & networks across species. We identified novel candidate genes for ADHD through integration across species and variant types. https://t.co/15lScKOsRq

@jennymaria @jonasvlachos @KGJLagerkranser @PetterLundborg Den här är ju också viktig: https://t.co/C6jfFR6Wzm

@CurrieJamie @AaronL001 @GodlessCranium @AuthorConfusion @DavidePiffer what expert has found the genetic code for intelligence? The modern GWAS research for educational attainment (EA) have found more than 1000 genetic code differences for IQ/EA. Here is r

@OzSyndicalist @majorityfm @EmmaVigeland https://t.co/QBexuw64C6

@tmwaring @KevinHong1991 yes, and as far as i understand, if one restricts themselves to EA GWAS, "good culture/education genes" might be primarily related to brain development, neural connection, the CNS... not sure how informative that really is at the e

“A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance.” https://t.c

@krichard1212 @tailcalled @SecretBaboon @ent3c Increased brain (cerebral cortex) size has been linked to increased IQ. Gene differences have been linked to educational attainment (EA3 polygenic score) and it has now been shown that many are genetically cor

Here's one such study: Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment https://t.co/SlIwQqa4Ut https://t.co/JFIU0PESEq

Does IQ have an impact that compensates for all the other racist, classist, ablest, socio-economic shit? Not really. https://t.co/KbrvDgOB2q

@lg__Ek Ok, det här är komplicerat. Jag ska försöka att förenkla det. 1. I en storskalig studie som omfattade över 1 miljon deltagare har forskare identifierat ett tusental genvarianter som är associerade med högre utbildningslängd. Den artikeln finns hä

Y aquí hay mucho que debatir ya que los científicos tenemos claro que la inteligencia es un concepto muy complejo con características genéticas pero también ambientales… https://t.co/22xHpWaB77

@wil_da_beast630 Theory: https://t.co/nSmjlJqwU6 https://t.co/MDiAEVEB3E Empirical evidence: https://t.co/iRa5uhMGc9 Specific alleles (in progress): https://t.co/pB1IJA0VaW https://t.co/d3Eg47IiFG https://t.co/pESOmnQkik (note that finishing 3 is argua

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals https://t.co/jrBhTG6GjD

@Superutz @DieTwychologin @4therecords Klingt vor allem nach Neid auf diejenigen die halt mehr Glück hatten. Diese Studie hat auf Basis von Daten von 1,1 Mio Menschen genetische Marker für statisch deutlich signifikante Unterschiede in den kognitiven Fähig

@rubenarslan @laurencejmshowe So the method used to estimate h2 simply requires to large a sample (like 6k minimum) to estimate h2 per study, the one study that did as far as I know is Lee et al. the big Edu GWAS (https://t.co/Sh2c04FKAG) their supp table

@ShaiCarmi https://t.co/OJOD6sdEio

First Behav Genetics Law: any trait is heritable. Educational attainment is discussed as an example: https://t.co/MZahuB58p6 Also an example of the "Fourth Law", that a typical trait is associated with many genetic variants, each explaining a small perce

@gregoryconnor11 @HumanVarieties @ResearchGate Lee et al.’s whole paper here is interesting, but just read their conclusion and the section on within-family sampling for what i’m talking about. https://t.co/csuKtLhHUg

@evo_homo @gcochran99 @TeaGeeGeePea @CovfefeAnon @arguablywrong @AryanCrash @ArchieN1966 @RhiannonDauster @EPoe187 "some of the predictive power of the polygenic score reflects environmental amplification of the genetic effects. Without controls for this b

@wil_da_beast630 @realchrisrufo ...by genetic factors summing additively - and 2) isn't contaminated by environmental influences (for example, "genetic nurture") and 3) is more-or-less equally predictive in the comparison groups. We're getting there. See

@monsoon0 Those genetic markers are FAR from a crystal ball... here's the GWAS paper where their markers came from: https://t.co/AsGN0xkxxw https://t.co/40AyGkxyof

RT @PGCgenetics: Reanalysis of CNVs across 11 published studies in ADHD showed enrichment of genes & networks across species. Novel candida…

Reanalysis of CNVs across 11 published studies in ADHD showed enrichment of genes & networks across species. Novel candidate genes for ADHD through integration across species and variant types. https://t.co/15lScL63IY

How come we never hear about this now well-established result from proponents of GWAS? Esp when they're writing these papers advocating for how some GWAS predict education so very well... That your scores are terrible for non-Whites seems like a rather fun

@jstevewhite @amiguello1 @Pseudobadger @SarahGrynpas @and_furiouser @karischoonbee @jessesingal No, GWAS identifies genes that have association with a particular phenotype. It is this collection of genes that is used in the paper (identified in Lee et al.

@BlackMa30578734 Une des études citées (la plus grosse en 2018 selon l'article) trouve que “les scores polygéniques expliquent 11-13% de la variance dans le succès scolaire et 7-10% de la variance dans les performance cognitives”. (Paye ton “hérédité bien

@AnarchoBoog @warren__terra @CarlSagan42O @AppositeRiposte @KateCagle @nycsouthpaw See figure 4 https://t.co/vgd8pT8s0M

@ProvNero @DrunkenPanda42 @Systemrelevant0 Mal einige Quellen dazu: https://t.co/ipVuzduoK5 https://t.co/05FoVA883Z https://t.co/QXmI9Brmld Zum Teil wurden auch schon Zusammenhänge zu spezifischen Genen hergestellt (jedoch nur kleinere Anteile): https://t.

@veroyeet @TedJasper1 @NBCNews https://t.co/7wtaJmW0TD There are studies coming out now showing that Europeans are much more likely than Africans to possess certain genes that predict intelligence. It's why there's been such a push to ban this kind of rese

12/25 As a result, our new PGS contains information about income over and above that contained in the PGS for educational attainment from our previous study in N~1.1mio individuals (see Table 4 and tweet 10 in this thread)... https://t.co/i7zcqXnsYC

7/25 26 of our loci were previously found to be associated with average household income https://t.co/p1Kox4Y7qB and 31 with educational attainment https://t.co/i7zcqXnsYC. Thus, the genetic architectures of different measures of socioeconomic attainment a

@charlesmurray EA herit (Silv ea 2020) is crit bec GWAS (Lee ea 2018, Dunkel ea 2019, Piffer 2019/20) req large SS and more direct/stand tests of GI are not curr ava at scale https://t.co/oaBq1FRfuZ https://t.co/FB2yUBidkn https://t.co/8NQLBi6FlL https://

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

@marosse @Estadao @soracy Acabei de te dar a reportagem da BBC que cita dados da OCDE e PISA. O vídeo do Atila tem as referências em baixo de pesquisas acadêmicas. https://t.co/RRtkURWzvw https://t.co/GVQnsAqvCu https://t.co/FK4CEdSNy9

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

@Thinking__T @Bioliberalism @symmo1969 @a_centrism @Parapraxis1980 @patrickamon @sapinker @Quillette sorry link for JJ Lee et al. was not correct, try this link https://t.co/EegwK9CREj

@Thinking__T @Bioliberalism @symmo1969 @a_centrism @Parapraxis1980 @patrickamon @sapinker @Quillette Some of the genomic DNA variation that influences IQ and educational attainment was identified by JJ Lee et al. https://t.co/g09rS6Or3V The polygenic score

@beowulf888 @sullydish Direct links here. https://t.co/a07xBJPIug https://t.co/YJoEmewNl8

@DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been determined by JJ Lee et al. https://t.co/EegwK9CREj These DNA variants show the ethnoracial group variation that is predicted by th

@vaxchoiceeast @joegooding @POTUS @realDonaldTrump @IamMonicaRae @nina14p @red_red_rita @JessieJaneDuff @125LolaLola @jjauthor @DGPurser @DonnaWR8 @RedNationRising I... do go into the topic in some detail. https://t.co/T5y4KQxCPM

@MMMalign Polygenic scores are based on the discovery study from Lee et al (2018). https://t.co/GpiKvL1trE

@primalpoly @ent3c The question of population differences in measurable IQ (or more crit trait GI) has not been "litigated". The research is only just getting started. Piffer (2019) - https://t.co/8NQLBi6FlL Dunkel et al. (2019) - https://t.co/IToB7Cengt

@glupyan Heritability estimates are derived from twin, sibling and adoption studies, and the consensus for IQ is that it's around 70-80% heritable in adults (see under Wilson Effect.) https://t.co/3juiQbIatW

@tdverstynen @EricsElectrons @CantlonLab You're bringing up the 'missing heritability' god-of-the-gaps argument? Really? The current number is ~10%, and we don't rely on GWAS results for heritability estimates. That's what twin, sibling and adoption stu

I'm not against GWAS. I love papers that are informative and not just a grocery list of associations. So far my favourite is SSGAC's EA3 GWAS. When you read the paper, you can easily tell that the authors know what they're talking about. https://t.co/UWeH

@cly_mene @verimad @myquestionx @a_centrism This is a highly counter-intuitive finding but widely replicated. Recent studies have also identified thousands of genetic markers associated with intelligence, which each have small individual but large cumulat

@izzynobre Chegou até a omitir variáveis do artigo https://t.co/wN9BXBBocZ

@BillHaywood96 @a_centrism ...It references the Lee et al study on polygenic scores for education attainment from 2018, if that's what mean? PGS involves computing from *many* SNPs. Look... you're gonna have to go read the paper if you want to discuss th

@Theodorez97 @izzynobre O artigo que a reportagem em https://t.co/joeRuIeJxw se baseia (https://t.co/wXor9OU6DF) também leva e consideração o ambiente e anos de escolaridade do indivíduo.

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals #InWhites https://t.co/KzZrH3X2Aj.

RT @LordGenome: @SuStenhouse Nauseating! The major hereditary component in “Ancient” families is wealth, not genes. But there is a genetic…

@SuStenhouse Nauseating! The major hereditary component in “Ancient” families is wealth, not genes. But there is a genetic component to educational achievement, this paper estimated at about 12% https://t.co/4I2Bf6BaNy

https://t.co/4DeD9gaPRB. @hsu_steve said that the supplementary material is one of the most impt reading material ever. It's too bad that so few of them are interested in the *structural biology* of these genes and how they can be affected by damage from n

@loveyou_eu @HassanHakimian 2/2 whoever wrote that article is forgetting one important thing: we are not all born alike. People differ in the amount of talent they have, and the distribution of talented individuals between population is unequal. See for

@Evolving_Moloch @JAB123421232 I'm not quite sure I get what you are saying. From what I can tell the 2018 GWAS Study from Colorado University and the database from 1000 genomes project (2008-2015) shows that the difference between groups in terms of IQ

@OmkarGV @JProtzko Some papers in behavioral genetics that might be of interest: https://t.co/8ElDRARacd https://t.co/gCHVmhorb5 Or easy intro book to IQ is "Intelligence: All that Matters?"https://t.co/tIFEnqqRgK

@JonathanKaplan @itsbirdemic This isn't hereditarian crap? https://t.co/lGv1ZZTVGo

@NicoleBarbaro Lee et al. (2018). Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment. Nature genetics, 50(8), 1112. https://t.co/FB2yUBidkn https://t.co/X6KmN0xpl4

Interesting study and a very well communicated summary of findings! Worth a read 🤓 TL;DR: (not surprising) phenotypic data i.e. parents education, parents SES or child's previous exam scores, was a better predictor of educational performance than polygeni

RT @bristimtom: We used data from @CO90s to see how well two polygenic scores for education (from https://t.co/3I2NYte4is) explained group…

We used data from @CO90s to see how well two polygenic scores for education (from https://t.co/3I2NYte4is) explained group variance and predicted individual participants' exam scores at ages 7 and 16, the first and final stages of compulsory schooling in t

@itsbirdemic How are they false? And hasn't the idea that the group differences are due to heritability been vindicated by this: https://t.co/lGv1ZZTVGo The frequency of the PGS hits in individuals was found in the linked article was found to be very

@bathwin @drjulie_b https://t.co/7i9PlAfi3I Only 7~10% of this heritability is due to the genome.