Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

Y aquí hay mucho que debatir ya que los científicos tenemos claro que la inteligencia es un concepto muy complejo con características genéticas pero también ambientales… https://t.co/22xHpWaB77

@wil_da_beast630 Theory: https://t.co/nSmjlJqwU6 https://t.co/MDiAEVEB3E Empirical evidence: https://t.co/iRa5uhMGc9 Specific alleles (in progress): https://t.co/pB1IJA0VaW https://t.co/d3Eg47IiFG https://t.co/pESOmnQkik (note that finishing 3 is argua

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals https://t.co/jrBhTG6GjD

@Superutz @DieTwychologin @4therecords Klingt vor allem nach Neid auf diejenigen die halt mehr Glück hatten. Diese Studie hat auf Basis von Daten von 1,1 Mio Menschen genetische Marker für statisch deutlich signifikante Unterschiede in den kognitiven Fähig

@rubenarslan @laurencejmshowe So the method used to estimate h2 simply requires to large a sample (like 6k minimum) to estimate h2 per study, the one study that did as far as I know is Lee et al. the big Edu GWAS (https://t.co/Sh2c04FKAG) their supp table

@ShaiCarmi https://t.co/OJOD6sdEio

First Behav Genetics Law: any trait is heritable. Educational attainment is discussed as an example: https://t.co/MZahuB58p6 Also an example of the "Fourth Law", that a typical trait is associated with many genetic variants, each explaining a small perce

@gregoryconnor11 @HumanVarieties @ResearchGate Lee et al.’s whole paper here is interesting, but just read their conclusion and the section on within-family sampling for what i’m talking about. https://t.co/csuKtLhHUg

@evo_homo @gcochran99 @TeaGeeGeePea @CovfefeAnon @arguablywrong @AryanCrash @ArchieN1966 @RhiannonDauster @EPoe187 "some of the predictive power of the polygenic score reflects environmental amplification of the genetic effects. Without controls for this b

@wil_da_beast630 @realchrisrufo ...by genetic factors summing additively - and 2) isn't contaminated by environmental influences (for example, "genetic nurture") and 3) is more-or-less equally predictive in the comparison groups. We're getting there. See

@strugglerred @BlacKierkegaard https://t.co/wPyYAWx1IN

@monsoon0 Those genetic markers are FAR from a crystal ball... here's the GWAS paper where their markers came from: https://t.co/AsGN0xkxxw https://t.co/40AyGkxyof

Source 3: https://t.co/8CNndqqStH

@biggayidiot_ @wewerewitches @nellfallcard @sentientist https://t.co/uGd6UppHjV

RT @PGCgenetics: Reanalysis of CNVs across 11 published studies in ADHD showed enrichment of genes & networks across species. Novel candida…

Reanalysis of CNVs across 11 published studies in ADHD showed enrichment of genes & networks across species. Novel candidate genes for ADHD through integration across species and variant types. https://t.co/15lScL63IY

RT @RogueWPA: I'd heard polygenic scores suck for populations different from the training set but didn't realize how bad it was. Lee et al…

How come we never hear about this now well-established result from proponents of GWAS? Esp when they're writing these papers advocating for how some GWAS predict education so very well... That your scores are terrible for non-Whites seems like a rather fun

I'd heard polygenic scores suck for populations different from the training set but didn't realize how bad it was. Lee et al (2018) report that their model trained on whites' education is 85% less effective at predicting blacks' education! https://t.co/UAn

@jstevewhite @amiguello1 @Pseudobadger @SarahGrynpas @and_furiouser @karischoonbee @jessesingal No, GWAS identifies genes that have association with a particular phenotype. It is this collection of genes that is used in the paper (identified in Lee et al.

@BlackMa30578734 Une des études citées (la plus grosse en 2018 selon l'article) trouve que “les scores polygéniques expliquent 11-13% de la variance dans le succès scolaire et 7-10% de la variance dans les performance cognitives”. (Paye ton “hérédité bien

@AnarchoBoog @warren__terra @CarlSagan42O @AppositeRiposte @KateCagle @nycsouthpaw See figure 4 https://t.co/vgd8pT8s0M

@ProvNero @DrunkenPanda42 @Systemrelevant0 Mal einige Quellen dazu: https://t.co/ipVuzduoK5 https://t.co/05FoVA883Z https://t.co/QXmI9Brmld Zum Teil wurden auch schon Zusammenhänge zu spezifischen Genen hergestellt (jedoch nur kleinere Anteile): https://t.

@veroyeet @TedJasper1 @NBCNews https://t.co/7wtaJmW0TD There are studies coming out now showing that Europeans are much more likely than Africans to possess certain genes that predict intelligence. It's why there's been such a push to ban this kind of rese

12/25 As a result, our new PGS contains information about income over and above that contained in the PGS for educational attainment from our previous study in N~1.1mio individuals (see Table 4 and tweet 10 in this thread)... https://t.co/i7zcqXnsYC

7/25 26 of our loci were previously found to be associated with average household income https://t.co/p1Kox4Y7qB and 31 with educational attainment https://t.co/i7zcqXnsYC. Thus, the genetic architectures of different measures of socioeconomic attainment a

@charlesmurray EA herit (Silv ea 2020) is crit bec GWAS (Lee ea 2018, Dunkel ea 2019, Piffer 2019/20) req large SS and more direct/stand tests of GI are not curr ava at scale https://t.co/oaBq1FRfuZ https://t.co/FB2yUBidkn https://t.co/8NQLBi6FlL https://

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

@marosse @Estadao @soracy Acabei de te dar a reportagem da BBC que cita dados da OCDE e PISA. O vídeo do Atila tem as referências em baixo de pesquisas acadêmicas. https://t.co/RRtkURWzvw https://t.co/GVQnsAqvCu https://t.co/FK4CEdSNy9

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

RT @RoyAFrye1: @DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been…

@Thinking__T @Bioliberalism @symmo1969 @a_centrism @Parapraxis1980 @patrickamon @sapinker @Quillette sorry link for JJ Lee et al. was not correct, try this link https://t.co/EegwK9CREj

@Thinking__T @Bioliberalism @symmo1969 @a_centrism @Parapraxis1980 @patrickamon @sapinker @Quillette Some of the genomic DNA variation that influences IQ and educational attainment was identified by JJ Lee et al. https://t.co/g09rS6Or3V The polygenic score

@beowulf888 @sullydish Direct links here. https://t.co/a07xBJPIug https://t.co/YJoEmewNl8

@DustinAventHolt @primalpoly @ent3c Some of the genomic DNA variation that influences IQ and educational attainment has been determined by JJ Lee et al. https://t.co/EegwK9CREj These DNA variants show the ethnoracial group variation that is predicted by th

@vaxchoiceeast @joegooding @POTUS @realDonaldTrump @IamMonicaRae @nina14p @red_red_rita @JessieJaneDuff @125LolaLola @jjauthor @DGPurser @DonnaWR8 @RedNationRising I... do go into the topic in some detail. https://t.co/T5y4KQxCPM

@MMMalign Polygenic scores are based on the discovery study from Lee et al (2018). https://t.co/GpiKvL1trE

@primalpoly @ent3c The question of population differences in measurable IQ (or more crit trait GI) has not been "litigated". The research is only just getting started. Piffer (2019) - https://t.co/8NQLBi6FlL Dunkel et al. (2019) - https://t.co/IToB7Cengt

@glupyan Heritability estimates are derived from twin, sibling and adoption studies, and the consensus for IQ is that it's around 70-80% heritable in adults (see under Wilson Effect.) https://t.co/3juiQbIatW

@SecretBaboon @benoit_cambron @a_centrism @EPoe187 > Omnigenic model = all genes involved in everything, which undermines your own GWAS tissue correlations which have lead to nothing. Lmao. You could look at high probability of causality SNPs in supp

@tdverstynen @EricsElectrons @CantlonLab You're bringing up the 'missing heritability' god-of-the-gaps argument? Really? The current number is ~10%, and we don't rely on GWAS results for heritability estimates. That's what twin, sibling and adoption stu

I'm not against GWAS. I love papers that are informative and not just a grocery list of associations. So far my favourite is SSGAC's EA3 GWAS. When you read the paper, you can easily tell that the authors know what they're talking about. https://t.co/UWeH

@cly_mene @verimad @myquestionx @a_centrism This is a highly counter-intuitive finding but widely replicated. Recent studies have also identified thousands of genetic markers associated with intelligence, which each have small individual but large cumulat

@izzynobre Chegou até a omitir variáveis do artigo https://t.co/wN9BXBBocZ

@BillHaywood96 @a_centrism ...It references the Lee et al study on polygenic scores for education attainment from 2018, if that's what mean? PGS involves computing from *many* SNPs. Look... you're gonna have to go read the paper if you want to discuss th

@Theodorez97 @izzynobre O artigo que a reportagem em https://t.co/joeRuIeJxw se baseia (https://t.co/wXor9OU6DF) também leva e consideração o ambiente e anos de escolaridade do indivíduo.

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals #InWhites https://t.co/KzZrH3X2Aj.

RT @LordGenome: @SuStenhouse Nauseating! The major hereditary component in “Ancient” families is wealth, not genes. But there is a genetic…

@SuStenhouse Nauseating! The major hereditary component in “Ancient” families is wealth, not genes. But there is a genetic component to educational achievement, this paper estimated at about 12% https://t.co/4I2Bf6BaNy

https://t.co/4DeD9gaPRB. @hsu_steve said that the supplementary material is one of the most impt reading material ever. It's too bad that so few of them are interested in the *structural biology* of these genes and how they can be affected by damage from n

@loveyou_eu @HassanHakimian 2/2 whoever wrote that article is forgetting one important thing: we are not all born alike. People differ in the amount of talent they have, and the distribution of talented individuals between population is unequal. See for

@Evolving_Moloch @JAB123421232 I'm not quite sure I get what you are saying. From what I can tell the 2018 GWAS Study from Colorado University and the database from 1000 genomes project (2008-2015) shows that the difference between groups in terms of IQ

@OmkarGV @JProtzko Some papers in behavioral genetics that might be of interest: https://t.co/8ElDRARacd https://t.co/gCHVmhorb5 Or easy intro book to IQ is "Intelligence: All that Matters?"https://t.co/tIFEnqqRgK

@JonathanKaplan @itsbirdemic This isn't hereditarian crap? https://t.co/lGv1ZZTVGo

@NicoleBarbaro Lee et al. (2018). Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment. Nature genetics, 50(8), 1112. https://t.co/FB2yUBidkn https://t.co/X6KmN0xpl4

Interesting study and a very well communicated summary of findings! Worth a read 🤓 TL;DR: (not surprising) phenotypic data i.e. parents education, parents SES or child's previous exam scores, was a better predictor of educational performance than polygeni

RT @bristimtom: We used data from @CO90s to see how well two polygenic scores for education (from https://t.co/3I2NYte4is) explained group…

We used data from @CO90s to see how well two polygenic scores for education (from https://t.co/3I2NYte4is) explained group variance and predicted individual participants' exam scores at ages 7 and 16, the first and final stages of compulsory schooling in t

@itsbirdemic How are they false? And hasn't the idea that the group differences are due to heritability been vindicated by this: https://t.co/lGv1ZZTVGo The frequency of the PGS hits in individuals was found in the linked article was found to be very

@bathwin @drjulie_b https://t.co/7i9PlAfi3I Only 7~10% of this heritability is due to the genome.

@bathwin @drjulie_b Heritability doesn't mean genetic. The environment here includes education, effect of wealth, nutrition, even the mother's nutrition. When you look at what the genome really explains, it's much lower : https://t.co/7i9PlzXHca

@davecurtis314 You argue is that it would be hard and slow, that environment matters more, and that we can't identify the relevant genes. But hard and slow doesn't mean not possible. And it seems like you're overstating the case regarding finding the gene

@Evil_Kirkecraap @Biorealism You can’t seriously believe genes have ZERO effect on cognitive ability. Among many other peer-reviewed papers: https://t.co/vgd8pT8s0M

@NickWolfinger The gap is between those that did or did not graduate from a 4-year college. Why's that a "Social Class Gap"? [Citation Needed] If you called it a "polygenic score gap", at least you'd have a citation in @nature. https://t.co/yJXHIkSPfx

China South probably means the Taishan-HK-Pearl River Delta; & BJ is capital, destination of best & brightest. China cooks the books on int’l tests and this is a key way they do it. We see their Boston not their rural WV.

RT @dbweissman: @WiringTheBrain @ent3c i'd be careful about this. with so many genes, you can get "dramatic" p-values with modest enrichmen…

@WiringTheBrain @ent3c i'd be careful about this. with so many genes, you can get "dramatic" p-values with modest enrichment. eg, https://t.co/zCV2yFjqjv, first two screenshots vs third https://t.co/cEKsGJvB3B

@DrBenNeel https://t.co/MhLyz2TcTd

In fact, I invite anyone to look through other studies of this nature, such as the Lee, “Educational Attainment’ study( https://t.co/darTuXCV1w ) or the Davies “g” study (https://t.co/6ayqaSFym6 )… 5/

@js_thrill Also see: https://t.co/MLzkw4RknN But insofar as you think my claim is misguided, imagine a possible world where humans attain perfect equality of opportunity in the sense that we eliminate the effects of zip codes, parental income, etc. on var

@HAAANBIN There is this blog post about pop. differences in IQ related genes: https://t.co/N6QhVHK1HA As well as 2 frequently cited studies by race realists about education attainment related genes: Piffer 2019 and Lee et al. 2018 https://t.co/BgN8Qnt8o

@UrFreundHannah Yeah apparently we’re in the era of using GWAS to study socio-economic and social “traits”… See https://t.co/0DQOZKDEN0 & https://t.co/IigRFDc1UN

#GWAS #Educational_attainment #Heritable_trait #SNPs https://t.co/2hBcAEwSav via @Get_Chirp https://t.co/NtvabNWZKn

RT @ewanbirney: @Plinker14 @Ananyo @Biorealism @RickPhillipsFL @hsu_steve @AdamRutherford Big meta analysis here. https://t.co/j5idqfuMgm…

@Plinker14 @Ananyo @Biorealism @RickPhillipsFL @hsu_steve @AdamRutherford Big meta analysis here. https://t.co/j5idqfuMgm Good solid stuff. Only thing that you have to watch in educational attainment (and it is tricky but fascinating) is that a fair propo

@soumia_e @lafleurdu54 Euh si https://t.co/oHurhD9Gsj https://t.co/WKUabicZgX https://t.co/0v5VeyJxoP https://t.co/9hCUt9I8wr

RT @KirkegaardEmil: @PsychRabble @HinterhaltS @IonaItalia @SkepticReview89 @nathancofnas Re. 1: Last GWAS on education found ~1300 approx.…

@PsychRabble @HinterhaltS @IonaItalia @SkepticReview89 @nathancofnas Re. 1: Last GWAS on education found ~1300 approx. independent variants. A specific GWAS on IQ found 18 approx. independent variants. The latter study is much smaller. https://t.co/tFnzHn

@VSealan @dr_l_alexandre C'est 20% en enfance, 80% à l'âge adulte pour les gènes t'inquiète pas ont en as découvert pleins qui explique 10% des variations entre les individus https://t.co/oHurhD9Gsj https://t.co/9hCUt9I8wr

@JohannesTextor @shell_ki Have you seen the screed of recent papers relating a polygenic score to years of education?? https://t.co/mqDOlIlVcS https://t.co/Mms3A6aHW4 https://t.co/nl9Pi1y1kT and loads more

@ExcludedMuddle @DrCherylllP @antonioregalado good point. 1. here are some further insights: https://t.co/JrIuPL6QH4 / https://t.co/aEe0H8RQVB 2. I´m not that sure that twin studies are the best option to study that (but may be my ignorance on the topic)

Fascinating to hear of the 'Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals' study by Lee et al (2018) & 'EduYears Polygenic' and Educational Attainment https://t.co/cMSy

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals https://t.co/HoSlVZoden via @BenPatrickWill

@TheGoodRv @Le__Noeliste @Polydamas @HenrydeLesquen L'heritabilité c'est l'heridité dans un environement donné donc vous avez faux j'ai déjà donné des liens et des gènes spécifique ont déjà été associé et predisent 7-10% de la variance https://t.co/WZMQqD

@shakimiki @Will_Tanner @nature https://t.co/OnTJWmb5sB

しょっぱなは、educational attainmentをゲノムで予測できるか、というチャレンジングなセッション。個人の予測は今の所難しく、古典的な予測因子にプラスする情報は少ない、というよくありがちな内容。論文を読めば情報はゲットできそうなので別のセッションへ移動。 https://t.co/e3Uq4YPcmb

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals | Nature #Genetics | #cognition #education #GWAS #inheritance #intelligence https://t.co/HR2FaXo1i7

@CalaveraSurfer

RT @AmirSariaslan: @GPledare För den intresserade: https://t.co/pKTkLPydWv

@GPledare För den intresserade: https://t.co/pKTkLPydWv

@HollyBahpullo Je suis Bioinformaticien Madame ! 😀 C est vraie qu il y a des maladies heritaires lie au chromosomeX, mais la majorite de l influence genetique sur l intelligence est lie a l autosome. Sur un echantillon de 1 million... https://t.co/tx6w3Xc3

@C_Kavanagh @Quillette The numbers are creeping up constantly, and explaining 10% of the variance is significant. https://t.co/U7bgNKiIO3

RT @UnsilencedSci: @AynMarx666 @nprfreshair @charleskingdc https://t.co/QBexuw64C6 https://t.co/tP0L03P5KN

@AynMarx666 @nprfreshair @charleskingdc https://t.co/QBexuw64C6 https://t.co/tP0L03P5KN

@PsychRabble @nathancofnas @SkepticReview89 @sarahbraasch1 @mikedennymike @C_Kavanagh @holzprueghel @ImHardcory @EPoe187 @BenWinegard @PamelaParesky @dunaevtimur @amyalkon @A_N_Pathy @Jon_StewartMill @minzlicht @yorl @phl43 @ArthurCDent @jonatanpallesen We

Re cooperation with biologists in social-science genetics: This is happening all the time and it's one of the reasons the most important papers in the field have dozens or hundreds of coauthors, e.g. https://t.co/XWVhj9lYOA

@CapitalismL @RussianBot88 @StefanMolyneux Four even when significant results are found, effects are really lame, for example using educational attrition as an IQ proxy, in the biggest GWAS study to the date, at most 11% explained https://t.co/t3nuUEYgN8