| Title |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
|
|---|---|
| Published in |
Nature Genetics, July 2018
|
| DOI | 10.1038/s41588-018-0147-3 |
| Pubmed ID | |
| Authors |
James J. Lee, Robbee Wedow, Aysu Okbay, Edward Kong, Omeed Maghzian, Meghan Zacher, Tuan Anh Nguyen-Viet, Peter Bowers, Julia Sidorenko, Richard Karlsson Linnér, Mark Alan Fontana, Tushar Kundu, Chanwook Lee, Hui Li, Ruoxi Li, Rebecca Royer, Pascal N. Timshel, Raymond K. Walters, Emily A. Willoughby, Loïc Yengo, Maris Alver, Yanchun Bao, David W. Clark, Felix R. Day, Nicholas A. Furlotte, Peter K. Joshi, Kathryn E. Kemper, Aaron Kleinman, Claudia Langenberg, Reedik Mägi, Joey W. Trampush, Shefali Setia Verma, Yang Wu, Max Lam, Jing Hua Zhao, Zhili Zheng, Jason D. Boardman, Harry Campbell, Jeremy Freese, Kathleen Mullan Harris, Caroline Hayward, Pamela Herd, Meena Kumari, Todd Lencz, Jian’an Luan, Anil K. Malhotra, Andres Metspalu, Lili Milani, Ken K. Ong, John R. B. Perry, David J. Porteous, Marylyn D. Ritchie, Melissa C. Smart, Blair H. Smith, Joyce Y. Tung, Nicholas J. Wareham, James F. Wilson, Jonathan P. Beauchamp, Dalton C. Conley, Tõnu Esko, Steven F. Lehrer, Patrik K. E. Magnusson, Sven Oskarsson, Tune H. Pers, Matthew R. Robinson, Kevin Thom, Chelsea Watson, Christopher F. Chabris, Michelle N. Meyer, David I. Laibson, Jian Yang, Magnus Johannesson, Philipp D. Koellinger, Patrick Turley, Peter M. Visscher, Daniel J. Benjamin, David Cesarini |
| Abstract |
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research. |
Twitter Demographics
The data shown below were collected from the profiles of 1,032 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 239 | 23% |
| United Kingdom | 91 | 9% |
| Spain | 26 | 3% |
| Canada | 26 | 3% |
| Netherlands | 20 | 2% |
| France | 18 | 2% |
| Australia | 17 | 2% |
| Germany | 16 | 2% |
| Brazil | 12 | 1% |
| Other | 130 | 13% |
| Unknown | 437 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 686 | 66% |
| Scientists | 276 | 27% |
| Practitioners (doctors, other healthcare professionals) | 41 | 4% |
| Science communicators (journalists, bloggers, editors) | 29 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,214 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1214 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 234 | 19% |
| Researcher | 182 | 15% |
| Student > Bachelor | 122 | 10% |
| Student > Master | 107 | 9% |
| Other | 72 | 6% |
| Other | 223 | 18% |
| Unknown | 274 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 215 | 18% |
| Agricultural and Biological Sciences | 143 | 12% |
| Medicine and Dentistry | 106 | 9% |
| Psychology | 101 | 8% |
| Neuroscience | 85 | 7% |
| Other | 209 | 17% |
| Unknown | 355 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2098. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2023.
All research outputs
#4,035
of 24,490,209 outputs
Outputs from Nature Genetics
#5
of 7,428 outputs
Outputs of similar age
#68
of 334,269 outputs
Outputs of similar age from Nature Genetics
#1
of 70 outputs
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