RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
Hoping to hear more about novel risk factors, especially genome-wide polygenic score. Great science like this needs to continue. Vaso provides Carotid IMT ultrasound, one of the most reliable risk facotors for Heart Attack and Stroke prevention.... http
Hoping to hear more about novel risk factors, especially genome-wide polygenic score. Great science like this needs to continue. Vaso provides Carotid IMT ultrasound, one of the most reliable risk facotors for Heart Attack and Stroke prevention. #CIMT
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
Capturing the common (5% of GenPop) and catastrophic (early MI prevalence 17%) with normal cholesterols. 👇🏾
RT @hmkyale: A better family history ... and also maybe ultimately a way to change destiny. The key here is that the knowledge of your gene…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
Polygenic risk score paper: https://t.co/7JB5zbanap
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @StuartJRitchie: For some reason I genuinely can’t fathom, polygenic scores have a lot of haters. This thread (and paper) should convinc…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @danweiner92: Exciting papers in @NatureGenet today, especially development+validation+clinical musings re genetic risk scores by @skath…
New powerful method to evaluate risk of common diseases from genetic data!
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @victor_faundes: La medicina de precisión cada vez más cerca de la práctica clínica habitual. Sin embargo, urge replicar estos estudios…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
Predicting heart attack (and other diseases) using the genome-wide polygenic score
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @whsource: "Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations". 8% of th…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @DrMJoyner: Look forward to seeing validated receiver operator curves and results of other standard procedures used to asses screening t…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @StuartJRitchie: For some reason I genuinely can’t fathom, polygenic scores have a lot of haters. This thread (and paper) should convinc…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
The same can be true for cancer predisposition, and is testable:
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
Killing it as always @amitvkhera and @skathire!!! Quite the team!!
RT @whsource: "Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations". 8% of th…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @danweiner92: Exciting papers in @NatureGenet today, especially development+validation+clinical musings re genetic risk scores by @skath…
RT @danweiner92: Exciting papers in @NatureGenet today, especially development+validation+clinical musings re genetic risk scores by @skath…
RT @danweiner92: Exciting papers in @NatureGenet today, especially development+validation+clinical musings re genetic risk scores by @skath…
RT @mbelshazly: Imagine knowing your genetic risk for all chronic diseases combined at an early age. I think it would definitely change man…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
Very nice study from @skathire group on ‘Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations’ https://t.co/cSmnmvU6Bb https://t.co/xbslo7jau9
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
Alazing data but also amazing that @NatureGenet accepts a a wrong title: a monogenic OR is >>10
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @danweiner92: Exciting papers in @NatureGenet today, especially development+validation+clinical musings re genetic risk scores by @skath…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @StuartJRitchie: For some reason I genuinely can’t fathom, polygenic scores have a lot of haters. This thread (and paper) should convinc…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
Figure on the right suggests risk is ~7% in the 80-100% group. What are risks of screening & additional work up in this group? What is the NN to screen? What would Gilbert Welch and the folks @DartmouthHitch have to say?
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @whsource: "Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations". 8% of th…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
"Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations". 8% of the population is at >3X risk of heart disease due to complex genetics. 3.5% for type 2 diabetes, 3.2% for inflammatory bowel dz.
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @StuartJRitchie: For some reason I genuinely can’t fathom, polygenic scores have a lot of haters. This thread (and paper) should convinc…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @StuartJRitchie: For some reason I genuinely can’t fathom, polygenic scores have a lot of haters. This thread (and paper) should convinc…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @StuartJRitchie: For some reason I genuinely can’t fathom, polygenic scores have a lot of haters. This thread (and paper) should convinc…
RT @danweiner92: Exciting papers in @NatureGenet today, especially development+validation+clinical musings re genetic risk scores by @skath…
The results of this work suggest that polygenic risk score for some complex diseases could be used already in clinical care!
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
Genetic predictors of coronary disease, atrial fibrillation, and type 2 diabetes that may be clinical actionable. https://t.co/psfKc2IMQ2
La medicina de precisión cada vez más cerca de la práctica clínica habitual. Sin embargo, urge replicar estos estudios en población latinoamericana, completamente sub-representada en este tipo de análisis genómicos.