RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
We should move away from average risk in screening for any conditions unless prevalence is high in particular population. Polygenic risk score is needed to recommend for routine screening. Aren’t we familiar with wasteful average risk screening in cardiolo
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
With the rapid advances in genomic technology and machine learning, that move may be coming sooner than many people think.
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @DrHBurstein: Polygenic scoring in breast was rather weak - moved prevalence from 4% to ~ 19% small fraction (0.1%) of women. False-posi…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
Polygenic scoring in breast was rather weak - moved prevalence from 4% to ~ 19% small fraction (0.1%) of women. False-positive means a "call back." The way to reduce that is to have radiologist review with patient in real-time.
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
60% de falsos positivos es una BURRADA https://t.co/3QBgG5oKDU
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% false positive rate over 10 yrs!). https://t.co/zWQBOQX7a3 When do we move from "average-risk" to add polygenic risk score? https://t
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @imarmean: .@minouye271: highlighting the important point made by @amitvkhera and @skathire et al. of binarising common traits to a leve…
RT @imarmean: .@minouye271: highlighting the important point made by @amitvkhera and @skathire et al. of binarising common traits to a leve…
RT @imarmean: .@minouye271: highlighting the important point made by @amitvkhera and @skathire et al. of binarising common traits to a leve…
.@minouye271: highlighting the important point made by @amitvkhera and @skathire et al. of binarising common traits to a level of disease risk comparable to a monogenic to capture extreme high risk tails https://t.co/LBeBXijemW #grd19
RT @ALEscamez: Polygenic risk scores as predictors of disease https://t.co/qPbBXU3RrH
Polygenic risk scores as predictors of disease https://t.co/qPbBXU3RrH
RT @EricTopol: The @23andMe data are quite similar to a recent @NatureGenet paper by @skathire @amitvkhera @pnatarajanmd and colleagues @br…
RT @SchreiberStuart: An informative thread from @EricTopol on promising genome-wide polygenic scores (GPS) to gain insights into disease –…
RT @EricTopol: The @23andMe data are quite similar to a recent @NatureGenet paper by @skathire @amitvkhera @pnatarajanmd and colleagues @br…
RT @EricTopol: The @23andMe data are quite similar to a recent @NatureGenet paper by @skathire @amitvkhera @pnatarajanmd and colleagues @br…
RT @EricTopol: The @23andMe data are quite similar to a recent @NatureGenet paper by @skathire @amitvkhera @pnatarajanmd and colleagues @br…
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations | @NatureGenet https://t.co/dJ0B7d36Ms
RT @SchreiberStuart: An informative thread from @EricTopol on promising genome-wide polygenic scores (GPS) to gain insights into disease –…
RT @EricTopol: The @23andMe data are quite similar to a recent @NatureGenet paper by @skathire @amitvkhera @pnatarajanmd and colleagues @br…
RT @SchreiberStuart: An informative thread from @EricTopol on promising genome-wide polygenic scores (GPS) to gain insights into disease –…
An informative thread from @EricTopol on promising genome-wide polygenic scores (GPS) to gain insights into disease – great to see Sek Kathiresan's (@skathire) study @NatureGenet
RT @EricTopol: The @23andMe data are quite similar to a recent @NatureGenet paper by @skathire @amitvkhera @pnatarajanmd and colleagues @br…
RT @EricTopol: The @23andMe data are quite similar to a recent @NatureGenet paper by @skathire @amitvkhera @pnatarajanmd and colleagues @br…
RT @EricTopol: The @23andMe data are quite similar to a recent @NatureGenet paper by @skathire @amitvkhera @pnatarajanmd and colleagues @br…
RT @EricTopol: The @23andMe data are quite similar to a recent @NatureGenet paper by @skathire @amitvkhera @pnatarajanmd and colleagues @br…
RT @EricTopol: The @23andMe data are quite similar to a recent @NatureGenet paper by @skathire @amitvkhera @pnatarajanmd and colleagues @br…
RT @EricTopol: The @23andMe data are quite similar to a recent @NatureGenet paper by @skathire @amitvkhera @pnatarajanmd and colleagues @br…
RT @EricTopol: The @23andMe data are quite similar to a recent @NatureGenet paper by @skathire @amitvkhera @pnatarajanmd and colleagues @br…
The @23andMe data are quite similar to a recent @NatureGenet paper by @skathire @amitvkhera @pnatarajanmd and colleagues @broadinstitute https://t.co/eRisYjHvSb https://t.co/srccTlmt8j
RT @Y_ECCO_IBD: Prof McGovern @doc_ibd on Complex genomics in #IBD Practical implications and future directions @Y_ECCO_IBD Basic Science…
RT @Y_ECCO_IBD: Prof McGovern @doc_ibd on Complex genomics in #IBD Practical implications and future directions @Y_ECCO_IBD Basic Science…
RT @Y_ECCO_IBD: Prof McGovern @doc_ibd on Complex genomics in #IBD Practical implications and future directions @Y_ECCO_IBD Basic Science…
RT @Y_ECCO_IBD: Prof McGovern @doc_ibd on Complex genomics in #IBD Practical implications and future directions @Y_ECCO_IBD Basic Science…
Prof McGovern @doc_ibd on Complex genomics in #IBD Practical implications and future directions @Y_ECCO_IBD Basic Science Workshop #ECCO2019 https://t.co/WVT5tFD0qe https://t.co/xMskWMeDaf #SoMe4IBD #genome https://t.co/EjpFohPeMQ
@Eva3034385615 Well there are 3 answers to that: On the positive side, I'm a big fan of @skathire work on polygenic risk scores, identifying combinations of variants that together indicate greater risk than well-known familial disorders: https://t.co/NoNsX
Genentech alum Matt Brauer joined Maze in October as VP Data Science. Scientific co-founder @skathire is one of the authors of this Nature paper last year https://t.co/Drr7ZpBYRH via @alexlash @xconomy
@OzCvA @USYD_CVI @garryjennings @DrEmmaLJohnston @realjosullivan @HRIAust @heartfoundation @HeartResearchAU Polygenic risk of heart dz a good place 2 start. Large proportions of population (particularly men) that: Follow steep vs flat risk trajectories ov
RT @cecilejanssens: The perspective is a reflection on last year's paper by @amitvkhera, @skathire and colleagues. https://t.co/xqHufr4Qz5…
The perspective is a reflection on last year's paper by @amitvkhera, @skathire and colleagues. https://t.co/xqHufr4Qz5 https://t.co/lsNZbJh1YV
See more here on polygenic scores: https://t.co/ckmI7vbmxq
A fully independent external validation of CAD polygenic scores from: Khera et al https://t.co/j2hTugFP03 Inouye/Abraham et al https://t.co/Dtc1RD74hp
RT @bnlasse: #genomics2020 AK shows polygenic risk score useful for identifying patients with >3-fold risk for coronary artery disease and…
RT @bnlasse: #genomics2020 AK shows polygenic risk score useful for identifying patients with >3-fold risk for coronary artery disease and…
#genomics2020 AK shows polygenic risk score useful for identifying patients with >3-fold risk for coronary artery disease and these individuals can NOT be distinguished by clinical risk factors; can generalize approach to other diseases https://t.co/rrq
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…