RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations https://t.co/lxKMfnlNyW
RT @MuinJKhoury: Genetic risk scores are back in the limelight. The approach can identify 1.5% to 8.0% of the population at greater than th…
RT @broadinstitute: What is a polygenic risk score? How is it calculated? Watch @skathire explain –in this video. Read his group's latest p…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @RonZimmernPHG: The original letter should be read by all interested in the use of genomics for disease prevention https://t.co/CjnFSYl0…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @broadinstitute: What is a polygenic risk score? How is it calculated? Watch @skathire explain –in this video. Read his group's latest p…
RT @cecilejanssens: My take home message from the latest polygenic risk paper: 6.6 million snps improve AUC by 0.015. In the derivation sam…
RT @StuartJRitchie: For some reason I genuinely can’t fathom, polygenic scores have a lot of haters. This thread (and paper) should convinc…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @MuinJKhoury: Genetic risk scores are back in the limelight. The approach can identify 1.5% to 8.0% of the population at greater than th…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @FAndreMD: polygenic risk score of breast cancer is currently being evaluated in a randomized trial testing personalized screening versu…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @jenniejlin: I hope an equally talented team can come up with a polygenic score for chronic #kidney disease too! What do you think, @kid…
RT @RonZimmernPHG: The original letter should be read by all interested in the use of genomics for disease prevention https://t.co/CjnFSYl0…
#HeartDisease #PolygenicRiskScore Polygenic risk score for heart disease: ready for prime time? The results should be eye-opening for cardiologists. https://t.co/oS7vycZ9a6 https://t.co/M9mt0zZsdJ @UMMC @UMmedschool @skathire @broadinstitute
RT @MehmetE_Krkmz: Çoklu gen analizi ile hastalık riski belirleme Önümüzde yeni bir pencere açılıyor Koroner arter hastalığı riskini belirl…
Current state of the art: have a single unlucky mutation and you have a 4x higher risk of heart attack, so targeted statins make sense This study: With whole genome sequencing we can identify 10x the number of patients with that same 4x elevated risk.
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
Study finds comparable cardiovascular disease risk in highest (LDpred) risk score group compared to monogenic mutations https://t.co/wccJdKsRCj "We propose that it is time to contemplate the inclusion of polygenic risk prediction in clinical care, and dis
RT @FAndreMD: polygenic risk score of breast cancer is currently being evaluated in a randomized trial testing personalized screening versu…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
Nice paper and thread on CVD polygenic risk by @skathire: genetic risk is non-linear, i.e. those at the top have substantially higher risk. Nice review by @markmccarthyoxf on similar story for T2D genetic risk https://t.co/dR9pz5Wu3j
What is a polygenic risk score? How is it calculated? Watch @skathire explain –in this video. Read his group's latest publication in @NatureGenet here: https://t.co/Kvq9i7UzGw https://t.co/A1pfpoCRSY
RT @cecilejanssens: My take home message from the latest polygenic risk paper: 6.6 million snps improve AUC by 0.015. In the derivation sam…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @annagloyn: #gamechanger translating GWAS into a clinically useful tool - kudos @skathire and team https://t.co/4m8d99ODAP
RT @cecilejanssens: My take home message from the latest polygenic risk paper: 6.6 million snps improve AUC by 0.015. In the derivation sam…
RT @cecilejanssens: My take home message from the latest polygenic risk paper: 6.6 million snps improve AUC by 0.015. In the derivation sam…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @annagloyn: #gamechanger translating GWAS into a clinically useful tool - kudos @skathire and team https://t.co/4m8d99ODAP
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @MuinJKhoury: Genetic risk scores are back in the limelight. The approach can identify 1.5% to 8.0% of the population at greater than th…
Supplementary Table 6 contains many risk score examples where complexity definitely does not improve over simplicity. Brilliant find!
RT @cecilejanssens: My take home message from the latest polygenic risk paper: 6.6 million snps improve AUC by 0.015. In the derivation sam…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @clopezcorrea: Great article in the use of #genomics for #orevention of common diseases https://t.co/CutXzpGQKf
Amazing waste of time, money, pixels, and value.
RT @timspector: There may still be hope that genes can help predict risk of common diseases - though a fair way to go still - even identica…
Great article in the use of #genomics for #orevention of common diseases
RT @cecilejanssens: My take home message from the latest polygenic risk paper: 6.6 million snps improve AUC by 0.015. In the derivation sam…
South Asians have much higher premature CAD. Is the risk genetic or result of lifestyle and/or conventional risk factors?
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
Nice discussion of polygenic scores and potential clinical applications. The @Nature paper here: https://t.co/PxNZOdyQzL
RT @StuartJRitchie: For some reason I genuinely can’t fathom, polygenic scores have a lot of haters. This thread (and paper) should convinc…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @timspector: There may still be hope that genes can help predict risk of common diseases - though a fair way to go still - even identica…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
Is it time to include genome-wide polygenic risk prediction in clinical care? A study in @NatureGenet argues for a strong 'yes'
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @IAmSusanPersky: Ok - this is a cool development - Polygenic risk scores exciting enough to propose clinical risk prediction for #type…
RT @timspector: There may still be hope that genes can help predict risk of common diseases - though a fair way to go still - even identica…
There may still be hope that genes can help predict risk of common diseases - though a fair way to go still - even identical twins get it wrong over half the time
RT @MehmetE_Krkmz: Çoklu gen analizi ile hastalık riski belirleme Önümüzde yeni bir pencere açılıyor Koroner arter hastalığı riskini belirl…
RT @cecilejanssens: My take home message from the latest polygenic risk paper: 6.6 million snps improve AUC by 0.015. In the derivation sam…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @MuinJKhoury: Genetic risk scores are back in the limelight. The approach can identify 1.5% to 8.0% of the population at greater than th…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @BiotechRadar: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations https:/…
My take home message from the latest polygenic risk paper: 6.6 million snps improve AUC by 0.015. In the derivation sample. It is hard to believe that a 6.6M snp model performs noticeably better than a 74 snp model. https://t.co/xqHufr4Qz5 https://t.co/O
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations https://t.co/EEqjsH2pdx
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
Çoklu gen analizi ile hastalık riski belirleme Önümüzde yeni bir pencere açılıyor Koroner arter hastalığı riskini belirlemede çoklu gen analizi skoru, konvansiyonel risk faktörlerinden çok üstün. https://t.co/o5eY1kXoW3 https://t.co/NPGV6Eldtz
RT @ElementoLab: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations https:/…
Neat article on prediction for polygenic diseases like type 2 diabetes! https://t.co/Z67uSvJle1
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @FAndreMD: polygenic risk score of breast cancer is currently being evaluated in a randomized trial testing personalized screening versu…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @EricTopol: Important assessment of polygenic risk scores for 5 common diseases @NatureGenet by @amitvkhera @skathire @broadinstitute @M…
RT @annagloyn: #gamechanger translating GWAS into a clinically useful tool - kudos @skathire and team https://t.co/4m8d99ODAP
RT @FAndreMD: polygenic risk score of breast cancer is currently being evaluated in a randomized trial testing personalized screening versu…
"... it has not yet been possible to use polygenic predictors to identify individuals at risk comparable to monogenic mutations. Here, we develop and validate genome-wide polygenic scores for five common diseases. The approach iden…https://t.co/zkb8cIX0Ii
@CMichaelGibson @skathire Thanks Mike. Open-access version: https://t.co/nRrfTVepty For those in top 1% of CAD score, 11% had a heart attack by mean age 57 (vs 0.8% in lowest 1%). Many more went on to develop CAD over next 7 years, and these are ones t
Ok - this is a cool development - Polygenic risk scores exciting enough to propose clinical risk prediction for #type2diabetes and coronary artery disease https://t.co/u7Ufw23pUs
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
A team led by @skathire has developed a tool that uses information from millions of places in the genome to calculate a person’s inherited risks for heart disease, breast cancer and other serious diseases. Learn more in their @NatureGenet paper: https://
You can find the paper in @NatureGenet here: https://t.co/pqlQ5e3wX1
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…