Impressive and important work. Yet more evidence that functional declines of aging are often reversible. Can't help but wonder if there's a mechanistic link to mTOR involved here given known connections. Congratulations!
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
😮
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @IndiraTurney: Congrats Mel @dr_ohsopretty & colleagues. Excellent work (in mice) focused on myeloid EP2 signaling inhibition & its role…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
Incredible paper! Thanks for the inspiration - I sent to the entire @KaczorowskiLab this morning.
RT @AlexJaraCarta: Congrats Melanie @dr_ohsopretty for the recent Nature article from the Andreasson and Rabinowitz Labs. Beautiful mechani…
the last sentence in the abstract caught my eye: "....reprogramming myeloid glucose metabolism to restore youthful immune functions". very cool paper @dr_ohsopretty
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
Restoring #metabolism of myeloid cells reverses cognitive decline in #ageing | Nature #macrophages #microglia https://t.co/a8ftIybDOp
Congratulations @dr_ohsopretty!
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @InterSciFellows: Congratulations to #ISFS2021 Fellow @dr_ohsopretty for her new paper - check it out! https://t.co/kFRNXpuuIw
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
Congratulations to #ISFS2021 Fellow @dr_ohsopretty for her new paper - check it out!
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @hir_kurashige: これ気になるなあ。 加齢による認知機能の低下が、骨髄細胞の代謝を抑制する分子シグナル(プロスタグランジン受容体の系)を阻害すると「回復」する。 予防ではなく回復! 神経炎症を改善させ、シナプス可塑性を回復させ、記憶能力を回復させる。…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
Check 👇🏾 out!!! #AlcornSTEM #HBCUSTEM #BlackandSTEM https://t.co/zVHFe93Q31
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
Congrats Mel!!! 🎊🍾🎈🎉 my friend is out here in these science & 🗣Nature streets & I love to see it 🥰
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
RT @IndiraTurney: Congrats Mel @dr_ohsopretty & colleagues. Excellent work (in mice) focused on myeloid EP2 signaling inhibition & its role…
RT @dr_ohsopretty: Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collabor…
Congrats Mel @dr_ohsopretty & colleagues. Excellent work (in mice) focused on myeloid EP2 signaling inhibition & its role in inflammation and reversing the aging process.
Will go down in history as one of my most memorable postdoctoral discoveries and contributions. It was pure joy collaborating with @parasmin on this project! Check it out below. https://t.co/H2yLmdptdH
RT @AlexJaraCarta: Congrats Melanie @dr_ohsopretty for the recent Nature article from the Andreasson and Rabinowitz Labs. Beautiful mechani…
RT @AgingBiology: Restoring metabolism of myeloid cells reverses cognitive decline in ageing https://t.co/cgGAzluBfv
RT @AgingBiology: Restoring metabolism of myeloid cells reverses cognitive decline in ageing https://t.co/cgGAzluBfv
Neat!!! https://t.co/LsvGIKRoFT
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
really cool study identifying that increases in PGE2 signaling in myeloid cells shift glucose metabolism to glycogen sequestration https://t.co/NB0MyaOUfS
RT @AgingBiology: Restoring metabolism of myeloid cells reverses cognitive decline in ageing https://t.co/cgGAzluBfv
Restoring metabolism of myeloid cells reverses cognitive decline in ageing https://t.co/cgGAzluBfv
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
RT @kipnislab: Manipulation of peripheral myeloid cells protects the ageing brain https://t.co/1N3cQZrti3
@bioMioSoftware @HealthyFellow This was a good one I posted yesterday:
RT @cterminiPHD: 👏👏👏
RT @AlexJaraCarta: Congrats Melanie @dr_ohsopretty for the recent Nature article from the Andreasson and Rabinowitz Labs. Beautiful mechani…
👏👏👏
RT @AlexJaraCarta: Congrats Melanie @dr_ohsopretty for the recent Nature article from the Andreasson and Rabinowitz Labs. Beautiful mechani…
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
Congrats Melanie @dr_ohsopretty for the recent Nature article from the Andreasson and Rabinowitz Labs. Beautiful mechanistic studies that show how inhibition of EP2 signaling can restore detriments from aging! https://t.co/mobKZYhmPl
🤔🧐 #Neurodégénérescence #vieillissement 🧠: une étude in vitro chez l'humain et in vivo chez la #souris 🐭 montre que la restauration du métabolisme jeune des cellules myéloïdes inverse le déclin cognitif en limitant l'inflammation qu'elles attisent https://
[L’étude a découvrir] 20/01 > La restauration du métabolisme des cellules myéloïdes inverse le déclin cognitif lié au vieillissement https://t.co/MyZVTkwSar via @nature #LaMethSci
@BenHobs3 For example, I find this paper very interesting. However, the low dimensional data presented leaves me to wonder if prostaglandin E2 is the only mediator (unlikely) or even the main mediator of the inflammatory phenotypes associated with aging.
#Aging gradually pushes #myeloid cells into an energy-deficient state which may promote pro-inflammatory responses. Intriguingly, rescue of this #metabolic state reverses cognitive decline in aging. Nice work @parasmin and coll. @StanfordMed https://t.co/
"PGE2 signalling through its EP2 receptor" "In aged mice,⬇️EP2➡️⬇️ .. inflammatory states⬆️spatial memory. Moreover, blockade of peripheral myeloid EP2 signalling is sufficient to restore cognition in aged mice." https://t.co/HtOenjZSye @agingdoc1 @Healthy
これ気になるなあ。 加齢による認知機能の低下が、骨髄細胞の代謝を抑制する分子シグナル(プロスタグランジン受容体の系)を阻害すると「回復」する。 予防ではなく回復! 神経炎症を改善させ、シナプス可塑性を回復させ、記憶能力を回復させる。 老化は回復できる…?! https://t.co/5HcVZHFLU0
RT @kipnislab: Manipulation of peripheral myeloid cells protects the ageing brain https://t.co/1N3cQZrti3
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
RT @nature: Cognitive decline can be reversed in mice by treating them with a drug that reduces inflammation and boosts the metabolism of i…
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
RT @kipnislab: Manipulation of peripheral myeloid cells protects the ageing brain https://t.co/1N3cQZrti3
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
Restoring metabolism of myeloid cells reverses cognitive decline in ageing. General public article: https://t.co/qPseyAod63 Original paper: https://t.co/AeZpi4eLzz
RT @andvoge: Keep your macrophages and their metabolism fit! Very impressive work hot off the press @nature https://t.co/4XI4XABUCo
RT @FrezzaLab: Restoring metabolism of myeloid cells reverses cognitive decline in ageing | Nature https://t.co/6o3dLFMZdg
Anti-aging research is getting more and more exciting by the day. Glucose, inflammation, microglia.. this paper has so many of my trigger words 🙈 https://t.co/5BDo52v83K
RT @aginghighlights: Restoring metabolism of myeloid cells reverses cognitive decline in ageing https://t.co/nBND8jECKR https://t.co/zd5Ko1…
#research Katrin Andreasson found out that 𝙘𝙤𝙜𝙣𝙞𝙩𝙞𝙫𝙚 #ageing 𝙞𝙨 𝙣𝙤𝙩 𝙖𝙣 𝙞𝙧𝙧𝙚𝙫𝙤𝙘𝙖𝙗𝙡𝙚 𝙘𝙤𝙣𝙙𝙞𝙩𝙞𝙤𝙣 𝙗𝙪𝙩 𝙘𝙤𝙪𝙡𝙙 𝙗𝙚 𝙧𝙚𝙫𝙚𝙧𝙨𝙚𝙙 by reducing inflammation and enhance macrophage metabolism https://t.co/ChuSjSt5dE #neuroscience #neurobiology https://t.co/8ycIiBCVV8
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
RT @nature: Cognitive decline can be reversed in mice by treating them with a drug that reduces inflammation and boosts the metabolism of i…
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
RT @DrMicroglia: Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
Restoring metabolism of myeloid cells reverses cognitive decline in ageing. (2021) https://t.co/mICraynv0N
RT @nature: Cognitive decline can be reversed in mice by treating them with a drug that reduces inflammation and boosts the metabolism of i…
RT @JuliaB_fitness: @_Simon_K @AgingBiology @nature «Another intriguing aspect of this study is the finding that even when EP2 inhibition w…
@_Simon_K @AgingBiology @nature «Another intriguing aspect of this study is the finding that even when EP2 inhibition was limited to the periphery in aged mice (using a substance that cannot enter the brain), brain inflammation was reversed and cognitive f
RT @kipnislab: Manipulation of peripheral myeloid cells protects the ageing brain https://t.co/1N3cQZrti3
inhibition of prostaglandin E2 receptor signalling rejuvenates cells, brain inflammation, hippocampal plasticity and memory, in mice. Wow! https://t.co/UImUnnjqT0
RT @kipnislab: Manipulation of peripheral myeloid cells protects the ageing brain https://t.co/1N3cQZrti3
Metabolic re-activation of macrophages counteracts brain aging. Very interesting study: https://t.co/DAAqRGGNTV
Restoring metabolism of myeloid cells reverses cognitive decline in ageing https://t.co/8bBFVqmKXS https://t.co/6OV7TPvuzX
RT @aginghighlights: Restoring metabolism of myeloid cells reverses cognitive decline in ageing https://t.co/nBND8jECKR https://t.co/zd5Ko1…
RT @jonykipnis: Absolutely remarkable paper 🤩🤩🤩
RT @nature: Cognitive decline can be reversed in mice by treating them with a drug that reduces inflammation and boosts the metabolism of i…
RT @MacLesggy: Un espoir contre le déclin cognitif des seniors ? Il peut être inversé chez les souris en les traitant avec un médicament qu…
RT @J_D_Anderson_UC: Inhibition of #PGE2 restored #metabolism of #myeloid cells reverses cognitive decline in aging mice https://t.co/Ihwiu…
RT @nature: Cognitive decline can be reversed in mice by treating them with a drug that reduces inflammation and boosts the metabolism of i…
RT @nature: Cognitive decline can be reversed in mice by treating them with a drug that reduces inflammation and boosts the metabolism of i…