RT @muramo10GP: ミクログリア細胞の代謝の回復は老化による認知機能障害を改善する。PUFA代謝産物であるPGE2は、マウスのミクログリア細胞の糖の酸化代謝を減らし、グリコーゲン貯蔵に回し、ATP産生量を減らす。 PGE2のブロックにより代謝を回復し、脳の炎症が減り…
ミクログリア細胞の代謝の回復は老化による認知機能障害を改善する。PUFA代謝産物であるPGE2は、マウスのミクログリア細胞の糖の酸化代謝を減らし、グリコーゲン貯蔵に回し、ATP産生量を減らす。 PGE2のブロックにより代謝を回復し、脳の炎症が減り、老化が元に戻る。 https://t.co/V0nLMdQEQc
Waaaaaat! Nog even en de discussie van mn proefschrift is gewoon al volledig aangetoond 😂.
Our study suggests that cognitive ageing is not a static or irrevocable condition but can be reversed by reprogramming myeloid glucose metabolism to restore youthful immune functions. https://t.co/UHIMbiTVk3
@HaoYin20 Hope these papers are good for you!! https://t.co/2wLvtY7qyw https://t.co/UOV18kOdhb https://t.co/mgTRDN2KzJ
RT @JuliaB_fitness: @exosome See this: «Peripheral EP2 (PGE2) blockade is sufficient to re-establish youthful immune homeostasis not only i…
@eugediana @philosophising4 It’s about this paper: https://t.co/tNeCfJbJOe https://t.co/nJ3LyP49Pd
@Kevin_McKernan @foundmyfitness I’m interested in aging and COX-2 and PGE2 are major aging factors & PGE2 inhibition is actually sufficient to reverse brain-aging pre-clinically. https://t.co/nJ3LyP49Pd
@statto The key to #antiaging/#agingReversal is the immune system. https://t.co/nJ3LyP49Pd
RT @JuliaB_fitness: @exosome See this: «Peripheral EP2 (PGE2) blockade is sufficient to re-establish youthful immune homeostasis not only i…
RT @JuliaB_fitness: @exosome See this: «Peripheral EP2 (PGE2) blockade is sufficient to re-establish youthful immune homeostasis not only i…
@exosome See this: «Peripheral EP2 (PGE2) blockade is sufficient to re-establish youthful immune homeostasis not only in the blood, but also in the brain, and to restore hippocampal function and plasticity in aged mice.»🤯 https://t.co/vdzKJuv6Mu https://t.
A 2021 study published in 'Nature' suggests that brain aging is NOT a permanent or irreversible condition! By reprogramming 'myeloid glucose metabolism' in mice they were able to restore youthful immune functions that reverse cognitive decline. #longevity
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
RT @robwilliamsiii: Restoring metabolism of myeloid cells reverses cognitive decline in ageing | Nature https://t.co/7LNmya7uan
Restoring metabolism of myeloid cells reverses cognitive decline in ageing | Nature https://t.co/7LNmya7uan
RT @JuliaB_fitness: @MitoPsychoBio This is cooler: https://t.co/6nRJ3mG6VK
RT @JuliaB_fitness: @MitoPsychoBio This is cooler: https://t.co/6nRJ3mG6VK
RT @JuliaB_fitness: @MitoPsychoBio This is cooler: https://t.co/6nRJ3mG6VK
@MitoPsychoBio This is cooler: https://t.co/6nRJ3mG6VK
@KarlHerrup Have you seen this? https://t.co/6nRJ3mG6VK
RT @JuliaB_fitness: @MrsKind_101 @CharlesMBrenner And yes, aging/phenotypes can be reversed, in both animals and humans. «Our study suggest…
RT @JuliaB_fitness: @MrsKind_101 @CharlesMBrenner And yes, aging/phenotypes can be reversed, in both animals and humans. «Our study suggest…
RT @JuliaB_fitness: @MrsKind_101 @CharlesMBrenner And yes, aging/phenotypes can be reversed, in both animals and humans. «Our study suggest…
@MrsKind_101 @CharlesMBrenner And yes, aging/phenotypes can be reversed, in both animals and humans. «Our study suggests that cognitive aging is not a static or irrevocable condition but can be reversed by reprogramming myeloid glucose metabolism to restor
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
RT @npure3: @onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in im…
@onelifemax @NaturePortfolio @NatureAging And a recent important #AgingReversal study showed inhibition of PGE2 signaling in immune cells rejuvenated cellular bioenergetics & restored cognition. This signaling can sustainably be decreased by #Omega3 bu
RT @MonneyMedMedia: What happens to macrophages with age? Check out a study by @parasmin & Prof Adreasson lab: https://t.co/Jznr9O81pc & ou…
@eugediana @CharlesMBrenner Easier said than done of course but this is very cool: Metabolic Reprogramming Rejuvenates Aged Myeloid Cells Restoring Cognition. 2021 (Inhibiting inflammatory PGE2/EP2 receptor signaling restores cognition in aged mice). https
@hthsci4bb3 EVIDENCE: Restoring metabolism of myeloid cells reverses cognitive decline in ageing https://t.co/ahA1opSoL6 #4bb3neuroimmune
@hthsci4bb3 EVIDENCE: Aging is initiated by pro-inflammatory responses which promote disease and cognitive decline. Researchers inhibit myeloid EP2 which rejuvenates neuroplasticity, spatial memory and brain inflammatory states. https://t.co/jFLixx6vuA
EVIDENCE: “Restoring metabolism of myeloid cells reverses cognitive decline in ageing” https://t.co/NWTbEgXyUc
Check out Drs. Rosa C. Paolicelli' s and Marlen Knobloch's Comments on this paper---Myeloid Metabolism as a New Target for Rejuvenation? https://t.co/Nbhvp8w5qs @ImmunoMet @Immune_News @humanimmunenews @Immunoscope https://t.co/3iWcUxgsBK
@hthsci4bb3 EVIDENCE ➡️ Restoring metabolism of myeloid cells reverses cognitive decline in ageing. https://t.co/5j20nDaK8B #4bb3neuroimmune
@hthsci4bb3 EVIDENCE: Inhibition of myeloid EP2 signalling leads to an increase in synaptic plasticity and spatial memory as well as a reduction in inflammation. https://t.co/CVlNGagc11
RT @immunometlab: Very accessible read on macrophage immunometabolism in aging by @abbyolena in @TheScientistLLC. Focusses on the @Nature p…
Very accessible read on macrophage immunometabolism in aging by @abbyolena in @TheScientistLLC. Focusses on the @Nature paper that we also covered in our @Cell_Metabolism commentary A Tweak to Immune Cells Reverses Aging in Mice https://t.co/UhWwts7g9O
@hthsci4bb3 EVIDENCE: Restoring metabolism of myeloid cells reverses cognitive decline in ageing https://t.co/NOUY12rP43 #4bb3neuroimmune
Restoring metabolism of myeloid cells reverses cognitive decline in ageing @Nature #cognitive #brainhealth #inflammation #PGE2 #memory https://t.co/QW0ZNzDElM
There is a lot of fascinating research out there. There are solid researchers: "cognitive ageing is not a static or irrevocable condition but can be reversed by reprogramming myeloid glucose metabolism to restore youthful immune functions." https://t.co/cJ
RT @immunometlab: Macrophage sana in corpore sano: https://t.co/l8KIYmVlTk Read our opinion in @Cell_Metabolism on the recent @nature paper…
Restoring metabolism of myeloid cells reverses cognitive decline in ageing | Nature https://t.co/ekB7fpoih1
RT @HSalmonowicz: Curious about how #macrophages #age? And how #mitochondria are regulated by #inflammatory cues to further drive #inflamma…
"reprogramming myeloid glucose metabolism to restore youthful immune functions" Woa - so where can I get the pills?
RT @ECNPtweets: The Early Career Advisory Panel (ECAP) recommends reading this article by Minhas et. al. showing that modulation of immune-…
The Early Career Advisory Panel (ECAP) recommends reading this article by Minhas et. al. showing that modulation of immune-cell #metabolism can restore age-related cognitive decline. To the article: https://t.co/22iWVziCDd #ECNP #AgeingBrain #brain @paras
"In ageing macrophages and microglia, PGE2 signalling through its EP2 receptor promotes the sequestration of glucose into glycogen, reducing glucose flux and mitochondrial respiration" https://t.co/b4VVlcg0br
4/15木曜(17時)のJCは、Restoring metabolism of myeloid cells reverses cognitive decline in ageing, Nature , 2021, https://t.co/ULHZSl5vwb...老化したマクロファージの代謝を回復させると認知機能も改善する(担当SS)。
Restoring metabolism of myeloid cells reverses cognitive decline in ageing https://t.co/wlq2LWPl1m
RT @HSalmonowicz: Curious about how #macrophages #age? And how #mitochondria are regulated by #inflammatory cues to further drive #inflamma…
RT @MonneyMedMedia: What happens to macrophages with age? Check out a study by @parasmin & Prof Adreasson lab: https://t.co/Jznr9O81pc & ou…
RT @HSalmonowicz: Curious about how #macrophages #age? And how #mitochondria are regulated by #inflammatory cues to further drive #inflamma…
RT @HSalmonowicz: Curious about how #macrophages #age? And how #mitochondria are regulated by #inflammatory cues to further drive #inflamma…
RT @MonneyMedMedia: What happens to macrophages with age? Check out a study by @parasmin & Prof Adreasson lab: https://t.co/Jznr9O81pc & ou…
RT @HSalmonowicz: Curious about how #macrophages #age? And how #mitochondria are regulated by #inflammatory cues to further drive #inflamma…
Curious about how #macrophages #age? And how #mitochondria are regulated by #inflammatory cues to further drive #inflammation? My latest #SciArt work below based on a fascinating study 🙂 #SciArtTweetStorm
What happens to macrophages with age? Check out a study by @parasmin & Prof Adreasson lab: https://t.co/Jznr9O81pc & our graphical summary by @HSalmonowicz -out of passion for sci illustration! #inflammation #ageing #macrophage #brain #SciArtTweetS
"Restoring metabolism of myeloid cells reverses cognitive decline in ageing" (@nature 2021) https://t.co/T2Lll40Zij
📢 Paras Minhas, Laboratory of Katrin Andreasson "Restoring metabolism of myeloid cells reverses cognitive decline in ageing" (@nature 2021) https://t.co/T2Lll40Zij
Journal Club Fri 18 Mar 12pm BIG13 Alice Parnell: Flight of the falcon: a bird’s migration decoded https://t.co/gvWJu3GDGr Sophie Mathiesen: Younger blood, younger brain: reverting the myeloid metabolic crisis https://t.co/92UZ2Jxw7G
Study reveals immune driver of brain aging https://t.co/bMv7cqpKT9 https://t.co/zYuwoZHNpE https://t.co/AN2laqaZvr
Keep your macrophages fit for healthy #aging aged macrophages downregulate glycolysis and mitochondrial oxidative phosphorylation, inducing an energy-deficient state that compromises macrophage function that together cause brain dysfunction. https://t.co/
RT @immunometlab: Macrophage sana in corpore sano: https://t.co/l8KIYmVlTk Read our opinion in @Cell_Metabolism on the recent @nature paper…
RT @immunometlab: Macrophage sana in corpore sano: https://t.co/l8KIYmVlTk Read our opinion in @Cell_Metabolism on the recent @nature paper…
RT @immunometlab: Macrophage sana in corpore sano: https://t.co/l8KIYmVlTk Read our opinion in @Cell_Metabolism on the recent @nature paper…
RT @immunometlab: Now being presented @KeystoneSymp #vksmetaimmune21: https://t.co/nVh9flRddE Keep your macrophages fit for healthy aging!
RT @immunometlab: Macrophage sana in corpore sano: https://t.co/l8KIYmVlTk Read our opinion in @Cell_Metabolism on the recent @nature paper…
RT @immunometlab: Macrophage sana in corpore sano: https://t.co/l8KIYmVlTk Read our opinion in @Cell_Metabolism on the recent @nature paper…
RT @immunometlab: Macrophage sana in corpore sano: https://t.co/l8KIYmVlTk Read our opinion in @Cell_Metabolism on the recent @nature paper…
Macrophage sana in corpore sano: https://t.co/l8KIYmVlTk Read our opinion in @Cell_Metabolism on the recent @nature paper by Minhas and colleagues (https://t.co/nVh9flRddE) #immunometabolism #keepyourmacrophagesfit @MCBI_AmsUMC
RT @BWFUND: From @nature - Restoring metabolism of myeloid cells reverses cognitive decline in ageing https://t.co/Q2vtvU58wf #bwfpdep
In conjunction with the work of Minhas et al (https://t.co/864EKZ5gIc), we think this work reveals the central importance of glycolysis in supporting important reparative functions of macrophages and identifies PGE2 as a key player in modulating this respo
PGE2 signaling and bioenergetics in monocyte derived macs in aging. https://t.co/ptIVluLxFS
RT @BWFUND: From @nature - Restoring metabolism of myeloid cells reverses cognitive decline in ageing https://t.co/Q2vtvU58wf #bwfpdep
RT @BWFUND: From @nature - Restoring metabolism of myeloid cells reverses cognitive decline in ageing https://t.co/Q2vtvU58wf #bwfpdep