@immunoboys Cool! Another possible contributor are the C4 genes w/i the MHC locus: https://t.co/OWyGQReLfp. Also ur post led me to this interesting tidbit from https://t.co/QTh24Q8Y9A would suggest some contribution of TLR7 GOF to AQP4-Ab production (or cl
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
Very insightful elaboration of how the strong linkage in the #HLA region can yield misleading associations
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
RT @doctorveera: Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit…
Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit the beautiful work by Kamitaki et al. from 2020 on the elegant dissection of the HLA GWAS signal (https://t.co/G1Qdm9SPiF), which is o
Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit the beautiful work by Kamitaki et al. from 2020 on the elegant dissection of the HLA GWAS signal (https://t.co/G1Qdm9SPiF), which is o
Glancing through a review of SLE genetics (https://t.co/0fIihGDwum), I bumped into a familiar plot, which made me revisit the beautiful work by Kamitaki et al. from 2020 on the elegant dissection of the HLA GWAS signal (https://t.co/G1Qdm9SPiF), which is o
RT @NaturePortfolio: A paper in Nature gives a genetic explanation behind the sex bias observed in some diseases. The findings suggest that…
RT @s_mccarroll: Many illnesses impact men and women differently for unknown reasons. In Nature today, @nkamitaki and our collaborative te…
https://t.co/i84whouZ1A ↓ちょっと前だけどこれも面白くて印象に残ってる。 疾患感受性と性差の話🚹🚺
@MitNak5 以前補体についても述べられてたかと思います。既読かもしれませんがhttps://t.co/eIsVDTgVtn https://t.co/RKj1FFE6l7 統合失調症と補体遺伝子変異について 面白いかと思いシェア致します。
Complement genes contribute sex-biased vulnerability in diverse disorders #HelsinkiHealth #tutkimus #tiede https://t.co/Bep16hDNBl
RT @LabTakei: Nature ハイライト:全身性エリテマトーデスとシェーグレン症候群の性特異的な影響における補体C4の役割 | Nature | Nature Research: https://t.co/MJpL2iBmcc
3. What is nature of Complement association in #autoimmunity ? Whole #genome sequence data to identify #complement C4A and C4B variants to impute gene copy number For each C4B copy number, higher C4A copy number is protective in #SLE. Stronger in men
RT @NatRevRheumatol: Links to the basic research papers covered by Richard Bucala at #ACR20 1. https://t.co/qgeLdBE8bl 2. https://t.co/a1…
RT @NatRevRheumatol: Links to the basic research papers covered by Richard Bucala at #ACR20 1. https://t.co/qgeLdBE8bl 2. https://t.co/a1…
RT @NatRevRheumatol: Links to the basic research papers covered by Richard Bucala at #ACR20 1. https://t.co/qgeLdBE8bl 2. https://t.co/a1…
RT @NatRevRheumatol: Links to the basic research papers covered by Richard Bucala at #ACR20 1. https://t.co/qgeLdBE8bl 2. https://t.co/a1…
RT @NatRevRheumatol: Links to the basic research papers covered by Richard Bucala at #ACR20 1. https://t.co/qgeLdBE8bl 2. https://t.co/a1…
RT @NatRevRheumatol: Links to the basic research papers covered by Richard Bucala at #ACR20 1. https://t.co/qgeLdBE8bl 2. https://t.co/a1…
#YearInReview Basic Science at #ACR20 by Dr. Buscarla: new insights on autoantibody origin and persistence, MHC susceptibility and greater role of complement variants, and RA progression and relapse (⬇️MerTK+ and ⬆️PRIME cells in relation to flares 👀)
Thank you! #ACR20
RT @rheuma_doktorin: Great service! #ACR20
RT @NatRevRheumatol: Links to the basic research papers covered by Richard Bucala at #ACR20 1. https://t.co/qgeLdBE8bl 2. https://t.co/a1…
Great service! #ACR20
Links to the basic research papers covered by Richard Bucala at #ACR20 1. https://t.co/qgeLdBE8bl 2. https://t.co/a1YF3EDVRq 3. https://t.co/DQDF7nRCSN 4. https://t.co/Gdv8xEQ48E 5. https://t.co/qbNsxTOQm4 6. https://t.co/yIh3sOAVGJ Happy reading!
RT @Magda_Skipper: Many common illnesses, from the autoimmune diseases systemic lupus erythematosus (SLE) to schizophrenia, differentially…
RT @matthewjharmer: Exploring complement and genetics @uhbwNHS #paedsnephro #journalclub https://t.co/XDEuZdRvUG @BAPNnephrology @VNijlovea…
Exploring complement and genetics @uhbwNHS #paedsnephro #journalclub https://t.co/XDEuZdRvUG @BAPNnephrology @VNijloveanu @CazPlatt @cecoupe_king @efi5777 @wenwyd20
#Neuroscience today: #Lupus and #Sjögren syndrome affect👩more than 👨, while #schizophrenia affects 👨more. What does the complement system (innate humoral immunity) contribute to these differences? 1/5 https://t.co/XbSOgQ3LCS
#Neurociencia hoy: El #lupus eritematoso sistémico y el síndrome de #Sjögren afectan más a las 👩que a los 👨, mientras que la #esquizofrenia afecta más a los 👨. ¿Que aporta el sistema de complemento (inmunidad humoral innata) a estas diferencias? 1/5 https
https://t.co/oFWkbtIiWq "Curse you. Curse you, demon lupus." https://t.co/sQ4zK8ccDf
RT @DrDiegoClemente: Of great interest for autoimmune disease researchers!!! C4A/C4B complement components genes, located in the MHC locus,…
Of great interest for autoimmune disease researchers!!! C4A/C4B complement components genes, located in the MHC locus, contribute to sex-biased vulnerability to schizophrenia, systemic lupus eruthematosus and Sjögren's syndrome. What about MS? https://t.
Nature ハイライト:全身性エリテマトーデスとシェーグレン症候群の性特異的な影響における補体C4の役割 | Nature | Nature Research: https://t.co/7nyi2mz5KA
Según los hallazgos publicados en la revista @NatureNeuro, las variantes genéticas en el sistema inmune dan como resultado vulnerabilidades basadas en el sexo a las enfermedades autoinmunes y la #esquizofrenia.🧬 Descubre más: 👉🏻 https://t.co/VtUZ3IGLEK htt
RT @NatureKorea: 네이처 하이라이트:다양한 질병에서 성 편견(Sex-biased) 취약점에 기여하는 보체 유전자(Complement genes) https://t.co/glXm9eaUAw
RT @ShaiCarmi: Really impressed by @s_mccarroll three fantastic papers in Nature within a few weeks! The latter two below are really game…
何を言ってんだかわかんないけど多分また分かったことが増えた https://t.co/UjyWbjD60r
RT @ky0sugar: 補体C4遺伝子のコピー数が多いとSLEとシェーンぐれんの発症リスクが低いので、男女で発症しやすさが違う疾患の性差は補体で説明できるかもって話。 補体量に男女差があるのは意外だった。 Complement genes contribute sex-b…
発症に性差のある3つの病気が一種類の遺伝子で説明がつくという面白い論文。SLEとシェーグレン症候群は女性に多く、統合失調症は男性に多い。どちらもMHC領域にある補体4A/Bのアレルが相互作用しているという論文。補体4は脳脊髄液での濃度が男性のほうが高いらしい。https://t.co/G5YZxlafrT
RT @ShaiCarmi: Really impressed by @s_mccarroll three fantastic papers in Nature within a few weeks! The latter two below are really game…
RT @ShaiCarmi: Really impressed by @s_mccarroll three fantastic papers in Nature within a few weeks! The latter two below are really game…
Looks like complement is about to be back in fashion (again): Complement genes contribute sex-biased vulnerability in autoimmune disorders including SLE. Data looks good. Fascinating idea. https://t.co/ubVSSfzDKP
RT @ky0sugar: 補体C4遺伝子のコピー数が多いとSLEとシェーンぐれんの発症リスクが低いので、男女で発症しやすさが違う疾患の性差は補体で説明できるかもって話。 補体量に男女差があるのは意外だった。 Complement genes contribute sex-b…
RT @ky0sugar: 補体C4遺伝子のコピー数が多いとSLEとシェーンぐれんの発症リスクが低いので、男女で発症しやすさが違う疾患の性差は補体で説明できるかもって話。 補体量に男女差があるのは意外だった。 Complement genes contribute sex-b…
RT @ky0sugar: 補体C4遺伝子のコピー数が多いとSLEとシェーンぐれんの発症リスクが低いので、男女で発症しやすさが違う疾患の性差は補体で説明できるかもって話。 補体量に男女差があるのは意外だった。 Complement genes contribute sex-b…
RT @ky0sugar: 補体C4遺伝子のコピー数が多いとSLEとシェーンぐれんの発症リスクが低いので、男女で発症しやすさが違う疾患の性差は補体で説明できるかもって話。 補体量に男女差があるのは意外だった。 Complement genes contribute sex-b…
RT @ky0sugar: 補体C4遺伝子のコピー数が多いとSLEとシェーンぐれんの発症リスクが低いので、男女で発症しやすさが違う疾患の性差は補体で説明できるかもって話。 補体量に男女差があるのは意外だった。 Complement genes contribute sex-b…
「全身性エリテマトーデス(SLE)とシェーグレン症候群(SjS)のリスクが、損傷した細胞由来の残屑に含まれる多くの自己抗原候補と免疫系との慢性的で持続的な相互作用から生じることが示唆された。」
Nature ハイライト:全身性エリテマトーデスとシェーグレン症候群の性特異的な影響における補体C4の役割 | Nature | Nature Research: https://t.co/MJpL2iBmcc
補体C4遺伝子のコピー数が多いとSLEとシェーンぐれんの発症リスクが低いので、男女で発症しやすさが違う疾患の性差は補体で説明できるかもって話。 補体量に男女差があるのは意外だった。 Complement genes contribute sex-biased vulnerability in diverse disorders https://t.co/xHTuMtAucf
This @s_mccarroll lab paper on how C4 contributes to sex differences is officially out! https://t.co/jgxeEIoKeq
[統合失調症]ハイライト:全身性エリテマトーデスとシェーグレン症候群の性特異的な影響における補体C4の役割 | Nature | Nature Researc(略)[08:18] https://t.co/BpLnsmLyib
Nature ハイライト:全身性エリテマトーデスとシェーグレン症候群の性特異的な影響における補体C4の役割 | Nature | Nature Research: https://t.co/TKX9FEVw9D
Nature ハイライト:全身性エリテマトーデスとシェーグレン症候群の性特異的な影響における補体C4の役割 | Nature | Nature Research: https://t.co/tMD4IvWr3W
RT @OdedRechavi: This sounds incredibly important: C4 alleles act more strongly in men than in women: combinations of C4A and C4B generated…
RT @ShaiCarmi: Really impressed by @s_mccarroll three fantastic papers in Nature within a few weeks! The latter two below are really game…
RT @ShaiCarmi: Really impressed by @s_mccarroll three fantastic papers in Nature within a few weeks! The latter two below are really game…
RT @NatureJapan: Nature ハイライト:全身性エリテマトーデスとシェーグレン症候群の性特異的な影響における補体C4の役割 | Nature https://t.co/jpTAP8aMo6 #遺伝学 #エリテマトーデス #シェーグレン症
RT @NatureJapan: Nature ハイライト:全身性エリテマトーデスとシェーグレン症候群の性特異的な影響における補体C4の役割 | Nature https://t.co/jpTAP8aMo6 #遺伝学 #エリテマトーデス #シェーグレン症
RT @NatureKorea: 네이처 하이라이트:다양한 질병에서 성 편견(Sex-biased) 취약점에 기여하는 보체 유전자(Complement genes) https://t.co/glXm9eaUAw
네이처 하이라이트:다양한 질병에서 성 편견(Sex-biased) 취약점에 기여하는 보체 유전자(Complement genes) https://t.co/glXm9eaUAw
RT @NatureJapan: Nature ハイライト:全身性エリテマトーデスとシェーグレン症候群の性特異的な影響における補体C4の役割 | Nature https://t.co/jpTAP8aMo6 #遺伝学 #エリテマトーデス #シェーグレン症
Nature ハイライト:全身性エリテマトーデスとシェーグレン症候群の性特異的な影響における補体C4の役割 | Nature https://t.co/jpTAP8aMo6 #遺伝学 #エリテマトーデス #シェーグレン症
RT @OdedRechavi: This sounds incredibly important: C4 alleles act more strongly in men than in women: combinations of C4A and C4B generated…
This sounds incredibly important: C4 alleles act more strongly in men than in women: combinations of C4A and C4B generated 14-fold variation in risk for SLE, 31-fold variation in risk for Sjögren’s syndrome, and 1.7-fold variation in schizophrenia risk htt
RT @oknatsume: Nature ハイライト:全身性エリテマトーデスとシェーグレン症候群の性特異的な影響における補体C4の役割 | Nature | Nature Research: #自己免疫疾患 https://t.co/Np6TzZUot3
RT @ShaiCarmi: Really impressed by @s_mccarroll three fantastic papers in Nature within a few weeks! The latter two below are really game…
Nature ハイライト:全身性エリテマトーデスとシェーグレン症候群の性特異的な影響における補体C4の役割 | Nature | Nature Research: #自己免疫疾患 https://t.co/Np6TzZUot3
Complement genes contribute sex-biased vulnerability in diverse disorders https://t.co/9Pvc5GmeMw 前も紹介したような気がするが
Really impressed by @s_mccarroll three fantastic papers in Nature within a few weeks! The latter two below are really game changers. https://t.co/hpvvADHa7t https://t.co/5DOF253Mrb https://t.co/Yx0kik0x5O
RT @NatRevRheumatol: #ResearchHighlight | Complement: the missing genetic link for SLE and pSS? #genetics #complement #lupus #Sjogren Rea…
RT @NatRevRheumatol: #ResearchHighlight | Complement: the missing genetic link for SLE and pSS? #genetics #complement #lupus #Sjogren Rea…
#ResearchHighlight | Complement: the missing genetic link for SLE and pSS? #genetics #complement #lupus #Sjogren Read the original research from @nature here https://t.co/0Debs1axDd Read our #news story here https://t.co/BVAqKF9Ojo
Complement Genes Contribute Sex-Biased Vulnerability in Diverse Disorders #amchelsinki #tutkimus https://t.co/Bep16hDNBl
Many common illnesses, for reasons that have not been identified, differentially affect #men and #women. Complement genes contribute sex-biased vulnerability in diverse #disorders https://t.co/28i0TO2GSA via @GenderInnovate
統合失調症とシェーグレン症候群、その性差と発症時期の違い、補体遺伝子の関係が見えて面白い論文 https://t.co/n1tA1VlQ4V
المراجع: (١) https://t.co/0ricSKVe6G (٢) https://t.co/jNHUXoEsd2 (٣) https://t.co/MJauWHIUv3 (٤)https://t.co/OEM1dO7lbN (٥)https://t.co/oS3HxgZh2k (٦)https://t.co/3mWqgshkqD
RT @Lupusreference: Why is systemic #lupus or #sjogren more common in #women? There are MANY explanations. Check this #openaccess @nature p…
Today's #Neuroscience #coolfact: We see sexual dimorphism in health and disease. #Lupus and Sjögren's disease affect women more, #schizophrenia affects men more. Complement system genes (part of innate immunity) were associated with these differences. http
Fascinating and well-written paper demonstrating that SLE and Sjogren's association with the MHC locus is actually driven by the C4A and C4B genes; high copy numbers of C4A and C4B protect against SLE and Sjogren's but increase the risk of schizophrenia.
Hoy en #Neurociencia: Vemos dimorfismo sexual en salud y enfermedad. El #lupus y la enfermedad de Sjögren afectan más a mujeres, la #esquizofrenia más a hombres. Se asociaron genes del sistema de complemento (inmunidad innata) a estas diferencias. https://
RT @Magda_Skipper: Many common illnesses, from the autoimmune diseases systemic lupus erythematosus (SLE) to schizophrenia, differentially…
RT @Magda_Skipper: Many common illnesses, from the autoimmune diseases systemic lupus erythematosus (SLE) to schizophrenia, differentially…