@DrNadolsky @AlpacaAurelius @kevinnbass @DaveKeto Then this. Ldl? Valid science? https://t.co/0IEWmpOiBO
@whsource @MaxCRoser @OurWorldInData @astokespop I don't suppose there's a similar dataset analysis for lipids (such as total cholesterol)? I do wonder what Yi et al 2019 would look like with maximum lifetime TC. https://t.co/38JeHdmsMp
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
RT @DBelardoMD: Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies…
Sigh. Let’s try this again 🙏 Consistent evidence from numerous and multiple different types of clinical and genetic studies unequivocally establishes that LDL causes ASCVD. https://t.co/iBujLgjqt3 https://t.co/DcRMUlh5bI
@DBelardoMD https://t.co/me7GvgnZar This science says you are incorrect.
@Jwith93 @SolBrah Here is a meta study which questions the relation between higher cholesterol and all cause mortality https://t.co/7evGqjIeLc
@dylanarmbruste3 @GeeEs15 @mosca_matthew @HealthnHacks @BiggestComeback @NutritionMadeS3 Ok. So what is the explanation? https://t.co/2H0kuFs1HY
@ScepticalDoctor @Nutradvance Relatively high (as per usual standards) total cholesterol is associated with the lowest mortality - but I'm sure you are very familiar with the fact that lipid-lowering treatments (particularly statins) do lower mortality, if
@mvholmes increase the incidence of T2DM, could the effect be way worse if PCSK9in in the long run? Here one study in Korean people, almost 13m people: https://t.co/2H0kuFs1HY
@BlockGeekDima This is a bit of an aside but check this out. Studies now showing that cholesterol has an optimum level in reducing all cause mortality; and it’s higher than we thought it should be https://t.co/B9ue1v7Y8P
@mosca_matthew All of the population studies? https://t.co/DQE9FLtst4 This one with 13m people. The only possible explanation is reverse causation. If this is not a viable explanation, as the authors pointed, then we have to think if lower is always better
Better yet, another study followed 12 million Koreans of all ages 18+ and found the lowest mortality among those with elevated cholesterol. https://t.co/300zqFbV3h
RT @Fabiensapiens: Je ne crois pas avoir posté ici cette petite étude. Le risque lié au cholestérol total suivrait une courbe en U. Il ser…
Semakin rendah kolesterol total, semakin tinggi mortalitasnya. Gak selamanya kolesterol rendah itu baik ya. https://t.co/kuWXuyoiq8
RT @ZKForTre: @acenuts My bad. Here you go https://t.co/NSeOptBSzP https://t.co/AnX4bSkBoG https://t.co/89LRk4JkAN https://t.co/kD1XqJT…
@DrPaulMason Seriously, pause your tired tropes and actually go to the literature. You clearly need to spend some time there. https://t.co/pNEwwmUUpT https://t.co/7YUABEg3Si https://t.co/KuituBf98u https://t.co/s6TZA9Stp3 https://t.co/AnX4bSkBoG htt
@MyNutritionSci @Gearoidmuar 20-year period had the worst all-cause mortality, and concluded that reverse causality was unlikely to account for the higher mortality associated with low cholesterol entirely" https://t.co/60t1Nc6V5D.
@Tom_Babington1 @DrMavro @DrPaulMason @dylanarmbruste3 This reverse causation Hypothesis is brought over and over to explain why low ldl higher ACM. https://t.co/oQ0KfwuP76 and https://t.co/2H0kuFs1HY (13m people) both studies in the discussion say RC do
https://t.co/jm8CTc9zJw age groups of 18–34, 35–44, 45–54, 55–64, 65–74, & 75–99 year old Koreans => each⬆️1 mmol/L TC⬆️mortality by 14%, 13%, 8%, 7%, 6% & 3% => TC ≥ 200 mg/dL⬇️mortality by 13%, 27%, 34%, 31%, 20% & 13%
@Tom_Babington1 @MountainVisions @Nutradvance There are a lot of studies that address this reverse causation hypothesis in enormous dataset and they express said RC is not plausible. RCT of drugs in sick people are not evidence for healthy individuals. h
@robbwolf This essentially says the same, but for all age groups and with a study cohort of 12.8 million https://t.co/slExGZ4GQt
Any thoughts on the data quality and reporting? Seems ⬆️ TC with ⬇️ risk factors are beneficial for 13 million Koreans. Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults | Scientific Reports ht
@The_Nutrivore @ScepticalDoctor Epidemiology is not all self-report. Consider this, for example. I think this is very interesting, but I am extremely hesitant to draw any definite conclusions about causality and direction, especially in light of experiment
See also this 2019 study of ~13m #Korean adults: "Total #cholesterol had U-curve associations with mortality in each age-sex group. TC levels associated with lowest mortality were 210–249 mg/dL [5.43-6.44 mmol/l; but lower for 18-34 year-olds]" https://t.c
@EcoDocTush @NutritionMadeS3 @kevinnbass @CarnivoreMD @joerogan So if reverse causality is not the explanation, it must have another one, or we need to (re)think the "lower is always better". 13m koreans, better for mortality TC 210-249mg-dl (maybe LDL in
@ShariqShamimMD @thisissudheer 150 is kind of low. in this study of 12.8 million people, levels that low were just as bad or worse than total of 300. could be the oils, or something else causing inflammation in the people above/below the apparent 200-220 s
Total cholesterol and mortality, a really big study. https://t.co/38JeHdmsMp
@AgustnMB @quequesierra @drmiguelmarcos ¿Seguro? ¿De verdad el colesterol "alto" (¿más de 190 se considera ya alto?) es un problema de salud, o una excusa para vender estatinas? Está claro que valores altos de verdad (>260) son malos, pero pocos hablan
KAYNAK https://t.co/DmeKG3avo7
@whsource I have no wonder, in light of the MR evidence against LDL, why high TC (most of which is LDL) is associated with increased longevity, not decreased. Perhaps the LDL-raising mutations are deleterious, rather than LDL per se? https://t.co/38JeHdms
RT @ScepticalDoctor: I suspect that low LDL-C is associated with increased mortality mostly because of reverse causation. In this study h…
I suspect that low LDL-C is associated with increased mortality mostly because of reverse causation. In this study healthy individuals were followed for over 20 years and no U-shape curve was found @FrogHarmless https://t.co/KxEOuDdZ3A https://t.co/aI
@ScepticalDoctor @Maclagan_was_OK For heart disease? Likely. For longevity? I'm not so sure, given that the nadir of the mortality U-curve for TC happens to be at nominally elevated levels. https://t.co/38JeHdmsMp
@ScepticalDoctor @realfoodcures @tednaiman Probably this: https://t.co/38JeHdmsMp
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Jevan: @DrNadolsky @POhukainen @AustinBaraki @kevinnbass @DBelardoMD @DaveKeto Interesting graph Spencer. How do you square it with ACM…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
@The_Nutrivore @IdanOnTweeter And how to interpret a study like this: https://t.co/2H0kuFs1HY Is it almost 25% of all population.
@MichaelMindrum @IMWHorvitz in the range of 130-150 mg-dl. https://t.co/2H0kuFs1HY
2/2 Second via @Jevan regarding LDL and All Cause Mortality: https://t.co/AvjP1qZnhk
@DrNadolsky @POhukainen @AustinBaraki @kevinnbass @DBelardoMD @DaveKeto Interesting graph Spencer. How do you square it with ACM data that says the lowest risk groups have a TC of 220-240? (Authors said reverse causality not sufficient). Do you believe in
@TGatliff In all ages Too high cholesterol is better than too low. The lowest mortality are at 210–249 mg/dL https://t.co/q4qcljhLCU
RT @Fabiensapiens: Je ne crois pas avoir posté ici cette petite étude. Le risque lié au cholestérol total suivrait une courbe en U. Il ser…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Fabiensapiens: Je ne crois pas avoir posté ici cette petite étude. Le risque lié au cholestérol total suivrait une courbe en U. Il ser…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults. "Too high cholesterol is better than too low. The lowest mortality are at 210–249 mg/dL" @Blagosklonny . Cholesterol management needs to be s
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
@alexeyguzey https://t.co/Gpf7IScj1l Seems familiar!
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
@yosoysusan @Sefuelix pues yo ya no se lo que tengo que hacer, estoy otra vez con la atorvastatina y todo al que pregunto dice que hay que tomarlas sí o sí.Lo que parece claro es que a partir de 70 años se mueren menos los que tienen colesterorl mas alto h
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
RT @Blagosklonny: I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! pe…
I noticed that the more important a study, the less interest it attracts when i tweet it 😀. This study in 12 million ! people shows that blood cholesterol less than 200 mg/dl is worse than high #cholesterol https://t.co/q4qcljhLCU
Je ne crois pas avoir posté ici cette petite étude. Le risque lié au cholestérol total suivrait une courbe en U. Il serait aussi dangereux de manquer de cholestérol que d'en avoir trop. L'optimum serait relativement élevé. https://t.co/4XTk6uudmp https:/
@Drlipid Is low possibility too low for TC?https://t.co/m4Ufk6AYXT
RT @Mangan150: Total cholesterol and all-cause mortality, association. If you had a cholesterol of 150, your doctor would have no comment,…
RT @Mangan150: Total cholesterol and all-cause mortality, association. If you had a cholesterol of 150, your doctor would have no comment,…
RT @Mangan150: Total cholesterol and all-cause mortality, association. If you had a cholesterol of 150, your doctor would have no comment,…
RT @Mangan150: Total cholesterol and all-cause mortality, association. If you had a cholesterol of 150, your doctor would have no comment,…
Is having low total Cholesterol good for you ? Not if you want to live longer! https://t.co/KZqqIvx9YU https://t.co/pX0mjfwc5y