@crisprtalk @zhaoweiasu @lecPokrandt @michaelfrazis @crisprtalk Thank you. HbF of 40% is > the 30% threshold for SCD alleviation; so, it seems fine as is & unclear whether BEAM's 101 with say 60% HbF will be clinically superior. Baffling lack of M
RT @davidrliu: - Lentiviruses that express non-sickling hemoglobin - Nucleases or base editors that disrupt DNA involved in silencing fetal…
RT @davidrliu: - Lentiviruses that express non-sickling hemoglobin - Nucleases or base editors that disrupt DNA involved in silencing fetal…
- Lentiviruses that express non-sickling hemoglobin - Nucleases or base editors that disrupt DNA involved in silencing fetal hemoglobin - Base editors that convert the SCD variant into a naturally occurring benign hemoglobin variant https://t.co/sicZyz9Gec
#WorldSickleCellDay is coming up June 19 🩸 #SCGE PI @davidrliu and researcher @Gregory_Newby of @broadinstitute look at #sicklecelldisease in this 2021 publication and use #baseediting to recover it 🧬https://t.co/ICDMw2dd1y
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @DRKAMALAYOUB: التوصل الى طريقة جديدة لعلاج الانيميا المنجلية بواسطة تعديل القاعدة الوراثية المسؤولة عن الخلل في انتاج كريات الدم الحمرا…
Newby et al. employed an adenine base editor to convert the sickle cell disease (SCD) allele into a non-pathogenic variant in haematopoietic stem and progenitor cells, and demonstrated rescue from SCD in humanized mice. (6/6) https://t.co/FEc3oK6VNq
RT @_allstripes: Congrats to our former research intern Kelcee Everette (@EveretteKelcee) on this new publication in @nature! #ShineTheLigh…
Congrats to our former research intern Kelcee Everette (@EveretteKelcee) on this new publication in @nature! #ShineTheLightOnSickleCell
Further Reading; https://t.co/Zi6NT1C5M7'
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @DrJOteroExpHem: Awesome!
Awesome!
RT @StJudeResearch: Sickle cell disease results from a mutation that causes pliable red blood cells to become brittle & sickle shaped. Scie…
RT @StJudeResearch: Sickle cell disease results from a mutation that causes pliable red blood cells to become brittle & sickle shaped. Scie…
RT @StJudeResearch: Sickle cell disease results from a mutation that causes pliable red blood cells to become brittle & sickle shaped. Scie…
RT @StJudeResearch: Sickle cell disease results from a mutation that causes pliable red blood cells to become brittle & sickle shaped. Scie…
RT @StJudeResearch: Sickle cell disease results from a mutation that causes pliable red blood cells to become brittle & sickle shaped. Scie…
Sickle cell disease results from a mutation that causes pliable red blood cells to become brittle & sickle shaped. Scientists used base editing to change the mutation. The resulting cells were less prone to sickling. https://t.co/YUWcj46f56 @JonathanYe
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @jyasuda1: 鎌形赤血球病のゲノム編集による治療モデルの論文。患者(ヒト)の血液幹細胞を体外でゲノム編集でベータグロビン遺伝子の変異を修復、免疫抑制マウスに移植して正常な血液産生を確認したなど。Nature誌 https://t.co/uqkTWR1XbB
鎌形赤血球病のゲノム編集による治療モデルの論文。患者(ヒト)の血液幹細胞を体外でゲノム編集でベータグロビン遺伝子の変異を修復、免疫抑制マウスに移植して正常な血液産生を確認したなど。Nature誌 https://t.co/uqkTWR1XbB
Very cool, indeed!
Cool. Sickle cell gets crispr'ed. https://t.co/kmXtlDlt0h
RT @EricTopol: The potential of a 1-shot #CRISPR base editing cure for sickle cell disease gets support and is exhilarating https://t.co/I0…
#Base #editing of haematopoietic stem cells rescues #sickle #cell disease in mice: https://t.co/Mg0p0chOEc
RT @EricTopol: The potential of a 1-shot #CRISPR base editing cure for sickle cell disease gets support and is exhilarating https://t.co/I0…
RT @stemcellpodcast: Featured in the roundup: Dr. @DavidRLiu, his team at @BroadInstitute, and their collaborators at @StJudeResearch used…
RT @stemcellpodcast: Featured in the roundup: Dr. @DavidRLiu, his team at @BroadInstitute, and their collaborators at @StJudeResearch used…
Featured in the roundup: Dr. @DavidRLiu, his team at @BroadInstitute, and their collaborators at @StJudeResearch used #BaseEditing to correct the mutation that causes #SickleCell Disease in HSPCs from patients. 🩸 Paper: https://t.co/JVg55YRNvb Episode: ht
RT @BioInn_CIEMAT: Edición de bases para corregir la anemia falciforme. Espectacular https://t.co/URPQ7oIfo0
RT @EricTopol: The potential of a 1-shot #CRISPR base editing cure for sickle cell disease gets support and is exhilarating https://t.co/I0…
RT @EricTopol: The potential of a 1-shot #CRISPR base editing cure for sickle cell disease gets support and is exhilarating https://t.co/I0…
RT @EricTopol: The potential of a 1-shot #CRISPR base editing cure for sickle cell disease gets support and is exhilarating https://t.co/I0…
RT @BioInn_CIEMAT: Edición de bases para corregir la anemia falciforme. Espectacular https://t.co/URPQ7oIfo0
RT @rjerala: Članek o popravilu mutacije v genu za hemoglobin, ki povzroča srpasto anemijo. Vsako leti se rodi 300.000 ljudi s to mutacijo,…
RT @BioInn_CIEMAT: Edición de bases para corregir la anemia falciforme. Espectacular https://t.co/URPQ7oIfo0
RT @beneitez_david: Absolutamente!!!
Absolutamente!!!
RT @BioInn_CIEMAT: Edición de bases para corregir la anemia falciforme. Espectacular https://t.co/URPQ7oIfo0
RT @BioInn_CIEMAT: Edición de bases para corregir la anemia falciforme. Espectacular https://t.co/URPQ7oIfo0
Edición de bases para corregir la anemia falciforme. Espectacular https://t.co/URPQ7oIfo0
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
Trending on PubMed: Base editing of haematopoietic stem cells rescues sickle cell disease in mice. https://t.co/rwOGKiYmk2
David Liu team @broadinstitute @Harvard @StJude @NIDDKgov @CincyChildrens perform base editing of haematopoietic stem cells. Rescues sickle cell disease in mice. Constructs from @ATUM_bio. Avoid p53 activation and large deletions common in cas9 treatment h
Baz editleme ile tanışın derim. Kalıtsal hastalıklarda yeni bir çağ açan teknoloji. Gen düzenlemenin en yeni ve en güvenli gen düzenleme teknolojisi. Bununla artık orak hücresi mutasyonunun düzeltilmesi hassasiyetle yapılabiliyor. https://t.co/fnZlpGjApr
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @norionakatsuji: 元論文→ https://t.co/mVKFpzsH3z
RT @norionakatsuji: “Base editing of haematopoietic stem cells rescues sickle cell disease in mice | Nature“ https://t.co/mVKFpzb5EZ
Base editing of haematopoietic stem cells rescues sickle cell disease in mice https://t.co/Hpa38BDTlA
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @norionakatsuji: 元論文→ https://t.co/mVKFpzsH3z
RT @norionakatsuji: 元論文→ https://t.co/mVKFpzsH3z
“Base editing of haematopoietic stem cells rescues sickle cell disease in mice | Nature“ https://t.co/mVKFpzb5EZ
Very exciting results from @davidrliu et al. study on a new base editing approach to treat #SickleCell. Congrats to the whole team on their work!
Nice work if you missed it: Base editing of haematopoietic stem cells rescues #SickleCell disease in mice https://t.co/gUzSGnHXwz
Sickle cell disease is the most common deadly genetic disorder in human. @davidrliu group reported in Nature that base editing can efficiently correct the mutation (GTG[Pathogenic]—>GCG[Benign variant]) in β-globin that causes SCD in mice. See the thre
In mouse experiments, scientists @broadinstitute have developed a way to edit specific DNA bases in human blood stem cell precursors to eliminate the sickle cell trait. @davidrliu @shengdarqtsai @LukeKoblan @kevintzhao93 @CPodracky @EveretteKelcee https:/
RT @NaturePortfolio: A study in @Nature reports the development and testing of base editors for genome editing of sickle cell disease. http…
Sickle cell anemia mutation can be corrected through adenine base editor. Recently published article in nature. https://t.co/eCdGSc0rhy
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @1000genes: En África la frecuencia del alelo llega al 20% por su tolerancia a la malaria. Los homocigotos sufren incapacidades graves…
RT @NaturePortfolio: A study in @Nature reports the development and testing of base editors for genome editing of sickle cell disease. http…
RT @NaturePortfolio: A study in @Nature reports the development and testing of base editors for genome editing of sickle cell disease. http…
RT @NaturePortfolio: A study in @Nature reports the development and testing of base editors for genome editing of sickle cell disease. http…
RT @NaturePortfolio: A study in @Nature reports the development and testing of base editors for genome editing of sickle cell disease. http…
RT @NaturePortfolio: A study in @Nature reports the development and testing of base editors for genome editing of sickle cell disease. http…
A study in @Nature reports the development and testing of base editors for genome editing of sickle cell disease. https://t.co/RwlvhhqUet https://t.co/6aafzG3Fqp
RT @Nature: A study in Nature reports the development and testing of base editors for genome editing of sickle cell disease. https://t.co/A…
RT @idemiguelb: Después de 25 años viendo la evolución de la biomedicina, tengo la sensación de que ahora es cuando de verdad estamos surfe…
RT @1000genes: En África la frecuencia del alelo llega al 20% por su tolerancia a la malaria. Los homocigotos sufren incapacidades graves…
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
Base editing strategy from @davidrliu, @Gregory_Newby, et al. demonstrates sickle cell rescue in mice! Base editing of haematopoietic stem cells rescues sickle cell disease in mice | Nature https://t.co/p7LOFcetWe
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @naifalmontashir: طريقة تعديل جيني أخرى وأكثر أمانا واستدامة Base Editing تثبت فاعليتها في علاج الأنيميا المنجلية في خلايا تم تعديلها من…
RT @NicoleGaudelli: A day late in congratulating @davidrliu and co-authors for this magnificent work! Curing sickle cell with ABE is a drea…
RT @john_evans3: Beautiful @nature paper from labs of David Liu and Mitch Weiss showing base editing correction of the sickle mutation, lea…
In biotech, CRISPR is one of the most exciting toolboxes we have for progress and this week @davidrliu and his team published findings on how to treat sickle cell disease in mice. As @WalterIsaacson has written, "molecules will be the new microchips." h
RT @EricTopol: The potential of a 1-shot #CRISPR base editing cure for sickle cell disease gets support and is exhilarating https://t.co/I0…
The future is now! Base-editor delivery ex vivo via mRNA for rescuing mice from sickle cell disease. Long $BEAM Incredible work
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
Base editing of bone marrow cells rescue sickle mice - a possibility of one-time transplant (if successful) for #sicklepatients @SCWarriorTweets News here: https://t.co/4KtcKuW2al… Journal article here: https://t.co/OVw6o39U7L #sicklecelldisease #genether
RT @DRKAMALAYOUB: التوصل الى طريقة جديدة لعلاج الانيميا المنجلية بواسطة تعديل القاعدة الوراثية المسؤولة عن الخلل في انتاج كريات الدم الحمرا…
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @DRKAMALAYOUB: التوصل الى طريقة جديدة لعلاج الانيميا المنجلية بواسطة تعديل القاعدة الوراثية المسؤولة عن الخلل في انتاج كريات الدم الحمرا…
RT @EricTopol: The potential of a 1-shot #CRISPR base editing cure for sickle cell disease gets support and is exhilarating https://t.co/I0…
RT @DRKAMALAYOUB: التوصل الى طريقة جديدة لعلاج الانيميا المنجلية بواسطة تعديل القاعدة الوراثية المسؤولة عن الخلل في انتاج كريات الدم الحمرا…
RT @birloque: Nunca pensé que llegaría a ver la curación (¡a nivel génico!) de esta enfermedad que tanto utilizamos como ejemplo de relacio…
التوصل الى طريقة جديدة لعلاج الانيميا المنجلية بواسطة تعديل القاعدة الوراثية المسؤولة عن الخلل في انتاج كريات الدم الحمراء ونجاح التجارب الاولية على الفئران. https://t.co/iZZt0rf8Xd
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…
Researchers have used #BaseEditing to convert the mutated allele that causes sickle cell disease into a non-pathogenic variant to rescue healthy globin production in mice. https://t.co/eXzzGUzoIZ
RT @davidrliu: Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that caus…