There are deletion reactions too, like this from Levin’s group. Not a general reaction though: it doesn’t work well with bulkier molecules, and tends to attack some sensitive functional groups. [ref https://t.co/hH8IKUfRrz ] https://t.co/AqqexTx4eP
RT @souyakuchan: 2級アミンから窒素を引き抜いてそのまま C-C 結合を作る反応、Nature。 C-H に官能基を付ける "peripheral editing" ではなく骨格自体を改変する "skeletal editing" の手法として提案。 当該反応試…
RT @souyakuchan: 2級アミンから窒素を引き抜いてそのまま C-C 結合を作る反応、Nature。 C-H に官能基を付ける "peripheral editing" ではなく骨格自体を改変する "skeletal editing" の手法として提案。 当該反応試…
RT @souyakuchan: 2級アミンから窒素を引き抜いてそのまま C-C 結合を作る反応、Nature。 C-H に官能基を付ける "peripheral editing" ではなく骨格自体を改変する "skeletal editing" の手法として提案。 当該反応試…
RT @uwyoongroup: Our winner was @LevinChem @group_levin (https://t.co/nBcckRsnK6). You can delete nitrogen, but this one won't be deleted f…
RT @uwyoongroup: Our winner was @LevinChem @group_levin (https://t.co/nBcckRsnK6). You can delete nitrogen, but this one won't be deleted f…
RT @uwyoongroup: Our winner was @LevinChem @group_levin (https://t.co/nBcckRsnK6). You can delete nitrogen, but this one won't be deleted f…
RT @uwyoongroup: Our winner was @LevinChem @group_levin (https://t.co/nBcckRsnK6). You can delete nitrogen, but this one won't be deleted f…
Our winner was @LevinChem @group_levin (https://t.co/nBcckRsnK6). You can delete nitrogen, but this one won't be deleted from our minds!
and @group_levin's skeletal editing through nitrogen deletion of secondary amines https://t.co/O3yzz5L10W
Felipe presented "Skeletal editing through direct nitrogen deletion of secondary amines" from @group_levin @LevinChem (read it here: https://t.co/fbwazISKad). (8/11)
Good..
With another year upon us, it's time for another term of recent paper discussions in #CHEM670 @chemistryatuvic! Last week to kick things off with a bang, we covered @LevinChem's skeletal editing work from @Nature. Extremely cool concept and execution! http
窒素除去による骨格編集の論文。すごい流行ってるイメージが勝手にある https://t.co/9mUTSqzshR
RT @mazuisake: 昨日一番衝撃的だったこと
RT @GloriusFrank: Equally amazing: published my favorite paper of the year: Skeletal Editing Through Direct Nitrogen Deletion of Secondary…
Equally amazing: published my favorite paper of the year: Skeletal Editing Through Direct Nitrogen Deletion of Secondary Amines https://t.co/qttuCQ8qCj Hearty congratulations! 👍🏆
RT @NatureSynthesis: In our #NSynthCollection and previously highlighted as an #NSynthPick @LevinChem @group_levin @UChiChemistry published…
RT @NatureSynthesis: In our #NSynthCollection and previously highlighted as an #NSynthPick @LevinChem @group_levin @UChiChemistry published…
In our #NSynthCollection and previously highlighted as an #NSynthPick @LevinChem @group_levin @UChiChemistry published in @Nature ❌Nitrogen deletion methodology of secondary amines 🎯Applied to editing of bioactive molecules 💡Mechanistic Insight https://t.
RT @group_levin: A huge congratulations to Sean, @balu_dherange, and Kate!! #skeletalediting https://t.co/iQu4JiX6bq
RT @NatureSynthesis: ICYMI: In this weeks #NSynthPick we feature the much talked about nitrogen deletion methodology developed by @LevinChe…
だるま落としみたいやな
RT @souyakuchan: 2級アミンから窒素を引き抜いてそのまま C-C 結合を作る反応、Nature。 C-H に官能基を付ける "peripheral editing" ではなく骨格自体を改変する "skeletal editing" の手法として提案。 当該反応試…
#synmet2021 This year we are testing new reactions from several groups, including @LevinChem (https://t.co/hYEk1hOMtK) @MacMillan_Lab (https://t.co/x73tDf1MBr) and @TristanHLambert (https://t.co/F2vvTfhDaY).
Interesting paper by @ZippelChristoph, Jasmin Seibert and @braeselab in @angew_chem. They highlight and frame the recent paper by @group_levin on skeletal editing by deletion of nitrogen from secondary amines (https://t.co/OcV4MfXDvQ). An interesting read
RT @souyakuchan: 2級アミンから窒素を引き抜いてそのまま C-C 結合を作る反応、Nature。 C-H に官能基を付ける "peripheral editing" ではなく骨格自体を改変する "skeletal editing" の手法として提案。 当該反応試…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
This morning we're talking about the novel idea of skeletal editing by N-atom deletion, discussing the interesting approaches from @group_levin at @UChiChemistry in @Nature (https://t.co/S4iVb4bVqq) and the Lu Group at Nanjing University in @angew_chem (ht
This is some really nice synthetic organic chemistry - a fundamentally new retrosynthetic disconnection. (Those are rare!) Good functional group tolerance too - just requires one side of amine to be benzylic. https://t.co/yRii27t5Rd
Skeletal editing through direct nitrogen deletion of secondary amines | Nature キモキモ https://t.co/Ko8DpYyPw7
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
holy moly this paper was fantastic!!! worth a read and a digest... 💪😋🍞
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
RT @souyakuchan: 2級アミンから窒素を引き抜いてそのまま C-C 結合を作る反応、Nature。 C-H に官能基を付ける "peripheral editing" ではなく骨格自体を改変する "skeletal editing" の手法として提案。 当該反応試…
RT @NatureSynthesis: ICYMI: In this weeks #NSynthPick we feature the much talked about nitrogen deletion methodology developed by @LevinChe…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @NatureSynthesis: ICYMI: In this weeks #NSynthPick we feature the much talked about nitrogen deletion methodology developed by @LevinChe…
RT @NatureSynthesis: ICYMI: In this weeks #NSynthPick we feature the much talked about nitrogen deletion methodology developed by @LevinChe…
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
昨日一番衝撃的だったこと
RT @souyakuchan: 2級アミンから窒素を引き抜いてそのまま C-C 結合を作る反応、Nature。 C-H に官能基を付ける "peripheral editing" ではなく骨格自体を改変する "skeletal editing" の手法として提案。 当該反応試…
New process that allows chemists to remove #nitrogen atoms from organic #molecules, offering novel approach to #OrganicSynthesis, developed by scientists @UChicago, USA. https://t.co/jJM3o9DfRp Read the abstract here: https://t.co/1JkybkQy1C #Pharmaceutic
RT @NatureSynthesis: ICYMI: In this weeks #NSynthPick we feature the much talked about nitrogen deletion methodology developed by @LevinChe…
RT @NatureSynthesis: ICYMI: In this weeks #NSynthPick we feature the much talked about nitrogen deletion methodology developed by @LevinChe…
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
RT @NatureSynthesis: ICYMI: In this weeks #NSynthPick we feature the much talked about nitrogen deletion methodology developed by @LevinChe…
RT @NatureSynthesis: ICYMI: In this weeks #NSynthPick we feature the much talked about nitrogen deletion methodology developed by @LevinChe…
RT @NatureSynthesis: ICYMI: In this weeks #NSynthPick we feature the much talked about nitrogen deletion methodology developed by @LevinChe…
RT @NatureSynthesis: ICYMI: In this weeks #NSynthPick we feature the much talked about nitrogen deletion methodology developed by @LevinChe…
Skeletal editing through direct nitrogen deletion of secondary amines https://t.co/GzYiavqtEA #science
RT @NatureSynthesis: ICYMI: In this weeks #NSynthPick we feature the much talked about nitrogen deletion methodology developed by @LevinChe…
ICYMI: In this weeks #NSynthPick we feature the much talked about nitrogen deletion methodology developed by @LevinChem @group_levin at @UChiChemistry published in @nature highlighted by @UnsworthChem and @ajavestro https://t.co/OZ2knOrkBf https://t.co/dtK
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
delet (the N atom) dis
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
「試薬 1c はもっと上手く盗む。抜き取る時 C-C 結合ができるからね」
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @souyakuchan: 2級アミンから窒素を引き抜いてそのまま C-C 結合を作る反応、Nature。 C-H に官能基を付ける "peripheral editing" ではなく骨格自体を改変する "skeletal editing" の手法として提案。 当該反応試…
RT @souyakuchan: 2級アミンから窒素を引き抜いてそのまま C-C 結合を作る反応、Nature。 C-H に官能基を付ける "peripheral editing" ではなく骨格自体を改変する "skeletal editing" の手法として提案。 当該反応試…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
Simple modification of the molecular scaffold, rather than the peripheral functional groups, holds such huge potential for discovery chemists. https://t.co/NjsAswaFiT https://t.co/sXqwpd6nga #newreaction #discoveryresearch #synthesis #medicinalchemistry ht
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
RT @Nature: Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in t…
Research in Nature shows how to delete nitrogen from organic molecules with secondary amines, forming a carbon-carbon bond in the process. https://t.co/MdUzDG73aD https://t.co/rWAtLyvn2r
Couple fragments with robust amine chemistry. Then delete nitrogen. Amazing!
Skeletal editing through direct nitrogen deletion of secondary amines https://t.co/6fWBUq79UD #nor論文 N-ピバロイルオキシ-N-アルコキシアミドを使って、二級アミンの窒素を直接除去してC-C結合形成。これ最初から狙ってたのか他反応の副産物なのかどっちなんだろう。使える文脈もありそうかな
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
Congratulations sir for wonderful work
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
Beautiful!
This one has to be one of the coolest reactions ever seen in a while. #CRISPRonmolecules #nitrogendeletion #simpleatitscore. Congratulations to all the authors for finding such off-the-track reactivity!!
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
Damn 😶 https://t.co/adpJUh1Pla
Did anyone else love this from @LevinChem? I'll see your Crispr then raise you an atomic stitching.
RT @JJSabatini: I think this nitrogen deletion chemistry is awesome work, with wide potential applications in organic synthesis. Congrats t…
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…
RT @JJSabatini: I think this nitrogen deletion chemistry is awesome work, with wide potential applications in organic synthesis. Congrats t…
RT @JJSabatini: I think this nitrogen deletion chemistry is awesome work, with wide potential applications in organic synthesis. Congrats t…
RT @LevinChem: Excited beyond words to share my lab's first research paper which is online today at Nature: https://t.co/IP0NLEkLId Have y…