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The hexadehydro-Diels–Alder reaction

Overview of attention for article published in Nature, October 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

1 news outlet
4 blogs
21 tweeters
1 Facebook page
1 Wikipedia page
1 Google+ user
2 Redditors


329 Dimensions

Readers on

306 Mendeley
The hexadehydro-Diels–Alder reaction
Published in
Nature, October 2012
DOI 10.1038/nature11518
Pubmed ID

Thomas R. Hoye, Beeraiah Baire, Dawen Niu, Patrick H. Willoughby, Brian P. Woods


Arynes (aromatic systems containing, formally, a carbon-carbon triple bond) are among the most versatile of all reactive intermediates in organic chemistry. They can be 'trapped' to give products that are used as pharmaceuticals, agrochemicals, dyes, polymers and other fine chemicals. Here we explore a strategy that unites the de novo generation of benzynes-through a hexadehydro-Diels-Alder reaction-with their in situ elaboration into structurally complex benzenoid products. In the hexadehydro-Diels-Alder reaction, a 1,3-diyne is engaged in a [4+2] cycloisomerization with a 'diynophile' to produce the highly reactive benzyne intermediate. The reaction conditions for this simple, thermal transformation are notable for being free of metals and reagents. The subsequent and highly efficient trapping reactions increase the power of the overall process. Finally, we provide examples of how this de novo benzyne generation approach allows new modes of intrinsic reactivity to be revealed.

Twitter Demographics

The data shown below were collected from the profiles of 21 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 306 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 2%
Germany 2 <1%
India 2 <1%
United Kingdom 2 <1%
Japan 2 <1%
Argentina 1 <1%
Belgium 1 <1%
Spain 1 <1%
Ireland 1 <1%
Other 1 <1%
Unknown 288 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 92 30%
Student > Master 44 14%
Researcher 39 13%
Student > Bachelor 38 12%
Student > Doctoral Student 21 7%
Other 51 17%
Unknown 21 7%
Readers by discipline Count As %
Chemistry 234 76%
Agricultural and Biological Sciences 8 3%
Medicine and Dentistry 7 2%
Biochemistry, Genetics and Molecular Biology 5 2%
Engineering 4 1%
Other 22 7%
Unknown 26 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 56. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2020.
All research outputs
of 17,635,820 outputs
Outputs from Nature
of 80,113 outputs
Outputs of similar age
of 143,993 outputs
Outputs of similar age from Nature
of 1,046 outputs
Altmetric has tracked 17,635,820 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 80,113 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 90.0. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 143,993 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1,046 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.