| Title |
Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing
|
|---|---|
| Published in |
Nature Communications, October 2012
|
| DOI | 10.1038/ncomms2077 |
| Pubmed ID | |
| Authors |
Emily C. McCusker, Claire Bagnéris, Claire E. Naylor, Ambrose R. Cole, Nazzareno D'Avanzo, Colin G. Nichols, B.A. Wallace |
| Abstract |
Voltage-gated sodium channels are vital membrane proteins essential for electrical signalling; in humans, they are key targets for the development of pharmaceutical drugs. Here we report the crystal structure of an open-channel conformation of NavMs, the bacterial channel pore from the marine bacterium Magnetococcus sp. (strain MC-1). It differs from the recently published crystal structure of a closed form of a related bacterial sodium channel (NavAb) by having its internal cavity accessible to the cytoplasmic surface as a result of a bend/rotation about a central residue in the carboxy-terminal transmembrane segment. This produces an open activation gate of sufficient diameter to allow hydrated sodium ions to pass through. Comparison of the open and closed structures provides new insight into the features of the functional states present in the activation cycles of sodium channels and the mechanism of channel opening and closing. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Canada | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 277 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 2% |
| Germany | 2 | <1% |
| United States | 2 | <1% |
| Austria | 1 | <1% |
| Canada | 1 | <1% |
| Czechia | 1 | <1% |
| Argentina | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 262 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 75 | 27% |
| Researcher | 45 | 16% |
| Student > Bachelor | 38 | 14% |
| Student > Master | 26 | 9% |
| Professor > Associate Professor | 15 | 5% |
| Other | 40 | 14% |
| Unknown | 38 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 85 | 31% |
| Biochemistry, Genetics and Molecular Biology | 53 | 19% |
| Chemistry | 38 | 14% |
| Medicine and Dentistry | 15 | 5% |
| Neuroscience | 11 | 4% |
| Other | 36 | 13% |
| Unknown | 39 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2016.
All research outputs
#2,424,379
of 22,679,690 outputs
Outputs from Nature Communications
#25,907
of 46,639 outputs
Outputs of similar age
#17,419
of 172,325 outputs
Outputs of similar age from Nature Communications
#53
of 169 outputs
Altmetric has tracked 22,679,690 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,639 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,325 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 169 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.