| Title |
Diverse architectural properties of Sso10a proteins: Evidence for a role in chromatin compaction and organization
|
|---|---|
| Published in |
Scientific Reports, July 2016
|
| DOI | 10.1038/srep29422 |
| Pubmed ID | |
| Authors |
Rosalie P. C. Driessen, Szu-Ning Lin, Willem-Jan Waterreus, Alson L. H. van der Meulen, Ramon A. van der Valk, Niels Laurens, Geri F. Moolenaar, Navraj S. Pannu, Gijs J. L. Wuite, Nora Goosen, Remus T. Dame |
| Abstract |
Sso10a proteins are small DNA-binding proteins expressed by the crenarchaeal model organism Sulfolobus solfataricus. Based on the structure of Sso10a1, which contains a winged helix-turn-helix motif, it is believed that Sso10a proteins function as sequence-specific transcription factors. Here we show that Sso10a1 and Sso10a2 exhibit different distinct DNA-binding modes. While the ability to bend DNA is shared between the two proteins, DNA bridging is observed only for Sso10a1 and only Sso10a2 exhibits filament formation along DNA. The architectural properties of Sso10a proteins suggest that these proteins fulfil generic roles in chromatin organization and compaction. As these proteins exhibit different binding behaviour depending on their DNA binding stoichiometry, altered levels of expression in the cell can be exploited to drive changes in local genome folding, which may operate to modulate transcription. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | 40% |
| United States | 1 | 20% |
| France | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 3% |
| Unknown | 30 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 23% |
| Student > Bachelor | 6 | 19% |
| Student > Ph. D. Student | 6 | 19% |
| Lecturer | 2 | 6% |
| Researcher | 2 | 6% |
| Other | 4 | 13% |
| Unknown | 4 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 42% |
| Agricultural and Biological Sciences | 12 | 39% |
| Physics and Astronomy | 2 | 6% |
| Unknown | 4 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2018.
All research outputs
#13,661,887
of 23,577,654 outputs
Outputs from Scientific Reports
#61,080
of 127,511 outputs
Outputs of similar age
#188,271
of 356,483 outputs
Outputs of similar age from Scientific Reports
#1,702
of 3,671 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
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