Chromatin context-dependent regulation and epigenetic manipulation of prime editing
Cell,
Prime editing exhibits strong, chromatin-related position effects and is promoted by active transcriptional elongation.
Prime editing exhibits strong, chromatin-related position effects and is promoted by active transcriptional elongation.
Fruit bats have honed their sweet tooth through adaptive evolution. Keith Rose/iStock via Getty Images…
Subunits of SWI/SNF chromatin remodeling complexes are often mutated in disease, but it has been difficult to predict gene…
Massively parallel variant annotation (MVAP) combines a number of functional genomics assays toward the functional…
CRISPR-Cas9 genome editing induces persistent chromosome loss in human primary T cells and engineered CAR T cells for clinical…
A multi-omics analysis-based resource across ten cancer types from more than 1,000 patients provides pan-cancer insights into…
Despite advances in molecular genetics, too many biologists think that natural selection is driven by random mutations - by…
Structural analysis of the human pre-replication complex provides clear insights into the initial stage of DNA melting during…
Az emberi genom tele van ősi vírusok maradványaival, amelyek egy része retrovírusok által okozott fertőzések ellen védhet…
A friend recently posted a figure on Facebook that instructs authors in the correct way to prepare a summary paragraph (abstract…
In spite of what you might have read, the human genome does not contain one million functional enhancers. The Sept. 15…
The human genome was first mapped in 2003, but it lacked full genetic information. Advancements in sequencing technology have…
journals.plos.org - Author summary Efficient and scalable data visualization of analysis is a critical bottleneck in biological…
We have recently published a Shiny (R) app called Cluster Identity Predictor (CIPR) in BMC Bioinformatics that helps annotate…
We have recently published a Shiny (R) app called Cluster Identity Predictor (CIPR) that helps annotate unnknown clusters in…
This post is mostly about a recent paper published in Studies in History and Philosophy of Biol
Some beating of dead horses may be ethical, where here and there they display unexpected twitches that look like life.Zuckerkandl…
Anshul Kundaje / Credit: Nalini…
Los lectores de noticias científicas probablemente os habréis encontrado más de una vez una historia que puede resumirse así: “De…
The team at UCSC Genome Browser continues to update their resources and offer new ways to find and visualize features of…
The team at UCSC Genome Browser continues to update their resources and offer new ways to find and visualize features of…
The December issue of Evolution: Education and Outreach has a review of two books on junk DNA. The reviewer is Georgi Marinov…
The ENCODE project began many years ago, with a pilot phase, that examined just 1% of the human genome. But this initial…
Are 01110000 01100001 01110010 01100001 [1] shifts a loss, a gain, a mismatch, or an opportunity for intellectual integration…
Review of The Vital Question by Nick Lane, Part 2 of 3 Last week, I covered the fundamentals, the outline of the history of…
An anonymous Christian creationist, who is honest enough to write under the moniker “Not A Scientist,” has done some…
The Mouse ENCODE Project released a slew of papers late last month reporting findings from a three-year effort to…
Fang, W., Wang, X., Bracht, J. R., Nowacki, M.,
Fang, W., Wang, X., Bracht, J. R., Nowacki, M.,
On the 24th of July, 2014 PLOS Genetics published an article entitled: “8.2% of the Human Genome Is Constrained: Variation in…
The world is not inhabited exclusively by fools and when a subject arouses intense interest and debate, as this one has…
Drama surrounding the $1000 genome erupts every so often, and earlier this year when the HiSeq X Ten setup was unveiled there…
According to a recent Science Daily news item, Oxford University researchers say that only 8.2% of our DNA is likely to be…
This week’s video tip shows you a new way to look at the multiWig track data at the UCSC Genome Browser. A new option has…
When the ENCODE Consortium published their results in September 2012, the popular press immediately seized upon the idea that…
From The Panda’s Thumb (http://pandasthumb.org/archives/evolution/junk-dna/) ENCODE Project Consortium et al. 2012. An…
Let's briefly review what happened in September 2012 when the ENCODE Consortium published their results (mostly in Nature). Here…
Genomes are like books of life. But until recently, their covers were locked. Finally we can now open the books and page…
Caption: NIH scientists used RNA interference to find genes that interact with the parkin protein (green), which tags damaged…
What has become of that simple 21,000-gene genome of ours? Today even the definition of gene is no longer clear. What biotypes…
ENCODE was a mammoth endeavor, and one that is helping to better shape our understanding of biology, but the project required a…
This is the fifth time that I get a letter from an author of the main ENCODE paper in Nature. And ti’s the fifth time that the…
By Michael LeVine, @thoughtculture Source: Wikimedia…
I collaborate with several investigators on gene expression projects using both microarray and RNA-seq. After I show a…
Updates from…
Learning more about altmetrics: essential…
A paper in the journal of Genome Biology and Evolution has been doing the rounds on the internet recently and was shown to me…
What kinds of research did people talk about in February? Here’s a hint: they didn’t talk much about love, but they did speak…
There's a new GB
Nivel: pelín avanzadoHace algunas semanas tuve la oportunidad de preparar un seminario sobre este proyecto, y después de leer…
Lo sé. Sé que os tengo abandonados... Estoy teniendo un arranque de cuatrimestre bastante liado, exposición sobre ENCODE en inglé…
Editor's note: For the No. 1 slot among evolution-related news stories of 2012, this one was an easy pick. The publication of…
One of the promises of altmetrics — an approach to measuring attention on research papers that relies on alternative measures…
TweetArticle-level metrics (or ALMs) were a hot topic at this week’s HighWire publisher meeting in Washington. (Highwire hosts…
As most ENV readers are aware, the scientific blogosphere has been abuzz in recent weeks over the recently published ENCODE…
September 5th saw the simultaneous publication of more than 30 papers in Nature, Genome Research and Genome Biology detailing…
A week ago, a huge, painstakingly orchestrated PR campaign was timed to coincide with multiple publications of a long-term…
Early last week, the science world was buzzing with the release of more than 30 papers highlighting the results from the 2nd…
The summer has not been an easy one for aficionados or practitioners of science writing. There was, of course, the ongoing…
Upon completion of the draft sequence of the human genome, it quickly became apparent that only a fraction of DNA (1-3%…
In this 5 minute tip I want to offer a constructive way to start to engage with ENCODE data. When the ENCODE consortium…
It is an unfortunate circumstance that ENCODE publicity decided to declare “junk DNA” dead, again. It’s not a totally unique…
Here and there in the blogosphere, people have begun defending ENCODE against criticism by noting that there is a lot more to…
To compare many different (including little-studied) languages around the world, comparative linguists need access to good data…
By Anjali Varma Desai, M.D Faculty Peer…
The raw numbers of the human genome: three billion base pairs, of which roughly 1% fall into the 20,000 genes in our genome. So…
University of Toronto biochemistry professor Larry Moran is not happy with the results of the ENCODE project, which report…
So I read in the newspaper this week that the ENCODE project has disproven the idea of junk DNA. I sure wish I’d gotten the memo…
The coining of the term “junk DNA” is credited to Susumu Ohno, who used it in two conference presentations that were later…
Fighting about ENCODE and…
The 21st Century began with a milestone for the human genome: a summer fanfare on Pennsylvania Avenue, two scientists and a…
A red junk at Tsim Sha TsuiAlfonso Jimenez and…
A few hours ago I criticized science journalists for getting suckered by the hype surrounding the publication of 30 papers from…
ENCODE (ENcyclopedia Of DNA Elements) is a massive consortium of scientists dedicated to finding out what's in the human genome.
The ENCODE project is an enormous international collaboration (>400 researchers), the goal of which is: to build a…
El proyecto de la Enciclopedia del ADN, llamado ENCODE por Encyclopedia of DNA Elements, ha estudiado con sumo detalle el ADN…
El proyecto piloto de la Enciclopedia del ADN, llamado ENCODE por Encyclopedia of DNA Elements, está estudiando con sumo…
A groundbreaking paper in Nature reports the results of the Encyclopedia of DNA Elements (ENCODE) project, which has detected…
A new wealth of articles by the ENCODE (the ENCyclopedia Of DNA Elements) consortium suggest that far more of the human genome…
One word for this project: MASSIVE. Holly…
Today, a scientific collaboration called the Encyclopedia of DNA Elements (ENCODE) published some of its data. When I say “collab…