| Title |
Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α
|
|---|---|
| Published in |
Nature Structural & Molecular Biology, August 2012
|
| DOI | 10.1038/nsmb.2364 |
| Pubmed ID | |
| Authors |
Nausica Arnoult, Amandine Van Beneden, Anabelle Decottignies |
| Abstract |
Gene silencing by the repressive telomeric chromatin environment, referred to as telomere position effect (TPE), has been well characterized in yeast and depends on telomere length. However, proof of its existence at native human chromosome ends has remained elusive, mainly owing to the paucity of genes near telomeres. The discovery of TERRAs, the telomeric noncoding RNAs transcribed from subtelomeric promoters, paved the way to probing for telomere-length impact on physiological TPE. Using cell lines of various origins, we show that telomere elongation consistently represses TERRA expression. Repression is mediated by increased trimethylated H3K9 density at telomeres and by heterochromatin protein HP1α, with no detectable spreading of the marks beyond the telomeric tract, restricting human TPE to telomere transcription. Our data further support the existence of a negative-feedback mechanism in which longer TERRA molecules repress their own transcription upon telomere elongation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 246 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 3 | 1% |
| Japan | 3 | 1% |
| United States | 2 | <1% |
| Canada | 2 | <1% |
| Brazil | 1 | <1% |
| India | 1 | <1% |
| Italy | 1 | <1% |
| Netherlands | 1 | <1% |
| Russia | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 230 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 77 | 31% |
| Researcher | 49 | 20% |
| Student > Master | 25 | 10% |
| Student > Bachelor | 16 | 7% |
| Student > Doctoral Student | 11 | 4% |
| Other | 33 | 13% |
| Unknown | 35 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 98 | 40% |
| Biochemistry, Genetics and Molecular Biology | 93 | 38% |
| Chemistry | 4 | 2% |
| Physics and Astronomy | 3 | 1% |
| Medicine and Dentistry | 3 | 1% |
| Other | 8 | 3% |
| Unknown | 37 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2013.
All research outputs
#16,722,190
of 25,374,917 outputs
Outputs from Nature Structural & Molecular Biology
#3,566
of 4,186 outputs
Outputs of similar age
#120,674
of 186,877 outputs
Outputs of similar age from Nature Structural & Molecular Biology
#31
of 45 outputs
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