| Title |
Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes
|
|---|---|
| Published in |
Nature Microbiology, June 2016
|
| DOI | 10.1038/nmicrobiol.2016.87 |
| Pubmed ID | |
| Authors |
Jianying Liu, Yang Liu, Kaixiao Nie, Senyan Du, Jingjun Qiu, Xiaojing Pang, Penghua Wang, Gong Cheng |
| Abstract |
The arbovirus life cycle involves viral transfer between a vertebrate host and an arthropod vector, and acquisition of virus from an infected mammalian host by a vector is an essential step in this process. Here, we report that flavivirus nonstructural protein-1 (NS1), which is abundantly secreted into the serum of an infected host, plays a critical role in flavivirus acquisition by mosquitoes. The presence of dengue virus (DENV) and Japanese encephalitis virus NS1s in the blood of infected interferon-α and γ receptor-deficient mice (AG6) facilitated virus acquisition by their native mosquito vectors because the protein enabled the virus to overcome the immune barrier of the mosquito midgut. Active immunization of AG6 mice with a modified DENV NS1 reduced DENV acquisition by mosquitoes and protected mice against a lethal DENV challenge, suggesting that immunization with NS1 could reduce the number of virus-carrying mosquitoes as well as the incidence of flaviviral diseases. Our study demonstrates that flaviviruses utilize NS1 proteins produced during their vertebrate phases to enhance their acquisition by vectors, which might be a result of flavivirus evolution to adapt to multiple host environments. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 30% |
| United Kingdom | 3 | 13% |
| France | 2 | 9% |
| Singapore | 1 | 4% |
| Mexico | 1 | 4% |
| Uruguay | 1 | 4% |
| Spain | 1 | 4% |
| Germany | 1 | 4% |
| Ecuador | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 4 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 57% |
| Scientists | 9 | 39% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 202 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | <1% |
| United States | 1 | <1% |
| France | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 197 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 18% |
| Researcher | 32 | 16% |
| Student > Bachelor | 31 | 15% |
| Student > Master | 28 | 14% |
| Student > Doctoral Student | 9 | 4% |
| Other | 19 | 9% |
| Unknown | 47 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 46 | 23% |
| Agricultural and Biological Sciences | 39 | 19% |
| Immunology and Microbiology | 31 | 15% |
| Medicine and Dentistry | 8 | 4% |
| Veterinary Science and Veterinary Medicine | 7 | 3% |
| Other | 16 | 8% |
| Unknown | 55 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2018.
All research outputs
#1,146,330
of 24,527,525 outputs
Outputs from Nature Microbiology
#999
of 1,895 outputs
Outputs of similar age
#22,228
of 360,494 outputs
Outputs of similar age from Nature Microbiology
#30
of 70 outputs
Altmetric has tracked 24,527,525 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,895 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 95.7. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,494 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.