| Title |
Type 3 Diabetes: Cross Talk between Differentially Regulated Proteins of Type 2 Diabetes Mellitus and Alzheimer’s Disease
|
|---|---|
| Published in |
Scientific Reports, May 2016
|
| DOI | 10.1038/srep25589 |
| Pubmed ID | |
| Authors |
Khyati Mittal, Ruchi Jakhmola Mani, Deepshikha Pande Katare |
| Abstract |
Type 3 Diabetes (T3D) is a neuroendocrine disorder that represents the progression of Type 2 Diabetes Mellitus (T2DM) to Alzheimer's disease (AD). T3D contributes in the increase of the total load of Alzheimer's patients worldwide. The protein network based strategies were used for the analysis of protein interactions and hypothesis was derived describing the possible routes of communications among proteins. The hypothesis provides the insight on the probable mechanism of the disease progression for T3D. The current study also suggests that insulin degrading enzyme (IDE) could be the major player which holds the capacity to shift T2DM to T3D by altering metabolic pathways like regulation of beta-cell development, negative regulation of PI3K/AKT pathways and amyloid beta degradation. |
X Demographics
The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 21% |
| Canada | 3 | 8% |
| United Kingdom | 3 | 8% |
| Mexico | 2 | 5% |
| India | 2 | 5% |
| Ireland | 1 | 3% |
| Tuvalu | 1 | 3% |
| South Africa | 1 | 3% |
| Tanzania, United Republic of | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 15 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 35 | 90% |
| Practitioners (doctors, other healthcare professionals) | 2 | 5% |
| Scientists | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 208 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Macao | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 206 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 40 | 19% |
| Student > Ph. D. Student | 30 | 14% |
| Student > Master | 30 | 14% |
| Researcher | 25 | 12% |
| Student > Doctoral Student | 10 | 5% |
| Other | 25 | 12% |
| Unknown | 48 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 40 | 19% |
| Medicine and Dentistry | 35 | 17% |
| Agricultural and Biological Sciences | 23 | 11% |
| Neuroscience | 16 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
| Other | 28 | 13% |
| Unknown | 59 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 44. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2021.
All research outputs
#917,896
of 24,796,076 outputs
Outputs from Scientific Reports
#9,598
of 135,618 outputs
Outputs of similar age
#16,128
of 304,471 outputs
Outputs of similar age from Scientific Reports
#241
of 3,206 outputs
Altmetric has tracked 24,796,076 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 135,618 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 304,471 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 3,206 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.