iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates. https://t.co/zbNxWMMqdE
Congratulations to Dr Alex Laperle and colleagues in Dr. Clive Svendsen's group at @CedarsSinai for their insightful work recently published in Nature Medicine on iPSC modelling of young-onset Parkinson’s disease: https://t.co/lRHucHAwna #Neuroscience #i
RT @AusStemCell: '#Parkinsons disease may start before birth - Stem cell study finds malfunctioning brain cells in patients who were diagno…
RT @AusStemCell: '#Parkinsons disease may start before birth - Stem cell study finds malfunctioning brain cells in patients who were diagno…
'#Parkinsons disease may start before birth - Stem cell study finds malfunctioning brain cells in patients who were diagnosed before age 50; researchers test potential new treatment' https://t.co/agaMCfsura Paper: https://t.co/Y7jNlboeQX https://t.co/gn6Om
RT @SpillantiniLab: Yesterday we had a great discussion about α-synuclein in iPSCs / how expression may influence seeding, a DOUBLE journal…
Yesterday we had a great discussion about α-synuclein in iPSCs / how expression may influence seeding, a DOUBLE journal club feature! Articles here: https://t.co/2pSJf21EN9 & here: https://t.co/ASBVy7FWV9 https://t.co/JL9Q37IIrw
iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates (Nat Med, Jan 2020): https://t.co/avig8qUyCf #Parkinsons #ParkinsonsDisease #StemCell #Neurobiology #GeneticDisorders #Biomarkers #Bi
Ramachandran Murali of @CedarsSinai contributed to a new publication in @NatureMedicine on young-onset Parkinson. https://t.co/SeHKOtIIKe https://t.co/p3uZprsby2
iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates https://t.co/tDwrmYPUU7
New promising therapeutic candidates for young-onset Parkinson’s disease. #neuroscience #brain #neuron #youngonsetparkinsonsdisease #parkinsonsdisease #biomarkers https://t.co/j9Xeh22lKO
Researchers at @CedarsSinai believe they have found a key mechanism behind young-onset Parkinson’s disease (YOPD). The discovery was reported in @NatureMedicine. Read more at: https://t.co/QOAuo3lS3G https://t.co/rDP08qBemB
RT @LiGanLab: A study using iPSC from Yong-Onset Parkinson's Disease patient showed increased accumulation of soluble α-synuclein protein a…
A study using iPSC from Yong-Onset Parkinson's Disease patient showed increased accumulation of soluble α-synuclein protein and reduced abundance of LAMP1, which can be normalized by specific phorbol esters, the activator of lysosome. https://t.co/JFRlYKU6
RT @NINDSdirector: Interesting phenotype found in IPScells differentiated into dopamine neurons from persons with young onset Parkinson's d…
#STEMCELL iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel ther https://t.co/ChJrpCqRaj
RT @BrundinPatrik: #iPSC modeling of young-onset #Parkinson disease reveals a molecular signature of disease and novel therapeutic candidat…
Young-onset #Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates: https://t.co/49txRKVWhY
RT @ShorterLab: iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates:…
Induced pluripotent stem cell-derived #dopaminergic cultures reveal a signature in patients with #YOPD who have no known #Parkinson’s disease-related mutations. Lysosomes, proteasomes, alpha-synuclein. #MSL #medicalaffairs https://t.co/4cIcFlIuB8 https://
iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates https://t.co/ynLTfxB4VZ
iPSC modeling of young-onset #Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates https://t.co/hmdDhLHsuw
RT @Ingentium_PD: iPSC modeling of young-onset #ParkinsonsDisease #PD reveals a molecular signature of disease and novel therapeutic candid…
iPSC modeling of young-onset #ParkinsonsDisease #PD reveals a molecular signature of disease and novel therapeutic candidates. https://t.co/W9t25JeGWH
#STEMCELL iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and https://t.co/ChJrpCqRaj
RT @NINDSdirector: Interesting phenotype found in IPScells differentiated into dopamine neurons from persons with young onset Parkinson's d…
Interesting phenotype found in IPScells differentiated into dopamine neurons from persons with young onset Parkinson's disease. https://t.co/ZjApZx3m5P
RT @EricTopol: So much to learn about #Parkinsonsdisease, which is on a steep rise. Here a @CedarsSinai made iPSCs from individuals w/ youn…
iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates. https://t.co/S4pnGen2VI
iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates. https://t.co/ZyQRoik65K
RT @RitchieHoLab: Congrats to my colleagues Alex Laperle, Sam Sances, and Nur Yucer for our much anticipated paper on modeling young-onset…
RT @RitchieHoLab: Congrats to my colleagues Alex Laperle, Sam Sances, and Nur Yucer for our much anticipated paper on modeling young-onset…
Congrats all!
RT @EricTopol: So much to learn about #Parkinsonsdisease, which is on a steep rise. Here a @CedarsSinai made iPSCs from individuals w/ youn…
RT @RitchieHoLab: Congrats to my colleagues Alex Laperle, Sam Sances, and Nur Yucer for our much anticipated paper on modeling young-onset…
RT @RitchieHoLab: Congrats to my colleagues Alex Laperle, Sam Sances, and Nur Yucer for our much anticipated paper on modeling young-onset…
Congrats to my colleagues Alex Laperle, Sam Sances, and Nur Yucer for our much anticipated paper on modeling young-onset Parkinson’s disease with iPSCs! https://t.co/leRh2hDtMP
早発 #PD 患者から #iPSC を生成、可溶性α-synuclein・リン酸化PKCαやLAMP1減量等 #PDシグナチュア を確認した。特異的ホルボールエステルPEP005でこのシグナチュアを消せた、と:Cedars-Sinai RMI。 https://t.co/hpZSKB1MEF
RT @BrundinPatrik: #iPSC modeling of young-onset #Parkinson disease reveals a molecular signature of disease and novel therapeutic candidat…
iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates: Analysis of the dopamine neurons showed they featured dysfunctional lysosomes, this appeared to result in a…https://t.co/5HSvlt7i6m
iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates https://t.co/LMOV5pIc5W PEP005 and other agents as potential treatments to reduce asyn. https://t.co/GoQ4na55Aw
Eye-catching but rather silly headline (that's genetics!) to an interesting study - lysosomal defects were NOT identified by RNA-seq, but proteins were impacted. Marriage of stem-cell iPSC to molecular mechanisms. https://t.co/n9ClGgv8L5 https://t.co/aULY1
RT @ScienceofPD: @CedarsSinai researchers generated IPS cells from YOPD individuals (with no known mutations), grew dopamine neurons which…
RT @EricTopol: So much to learn about #Parkinsonsdisease, which is on a steep rise. Here a @CedarsSinai made iPSCs from individuals w/ youn…
RT @BrundinPatrik: #iPSC modeling of young-onset #Parkinson disease reveals a molecular signature of disease and novel therapeutic candidat…
RT @ScienceofPD: @CedarsSinai researchers generated IPS cells from YOPD individuals (with no known mutations), grew dopamine neurons which…
RT @BrundinPatrik: #iPSC modeling of young-onset #Parkinson disease reveals a molecular signature of disease and novel therapeutic candidat…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ESC_iPSC_News: Exciting research out today from @CedarsSinai in @NatureMedicine: iPSC modeling of young-onset #Parkinson’s disease reve…
RT @EricTopol: So much to learn about #Parkinsonsdisease, which is on a steep rise. Here a @CedarsSinai made iPSCs from individuals w/ youn…
RT @ESC_iPSC_News: Exciting research out today from @CedarsSinai in @NatureMedicine: iPSC modeling of young-onset #Parkinson’s disease reve…
RT @EricTopol: So much to learn about #Parkinsonsdisease, which is on a steep rise. Here a @CedarsSinai made iPSCs from individuals w/ youn…
RT @EricTopol: So much to learn about #Parkinsonsdisease, which is on a steep rise. Here a @CedarsSinai made iPSCs from individuals w/ youn…
RT @ESC_iPSC_News: Exciting research out today from @CedarsSinai in @NatureMedicine: iPSC modeling of young-onset #Parkinson’s disease reve…
RT @ShorterLab: iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates:…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @EricTopol: So much to learn about #Parkinsonsdisease, which is on a steep rise. Here a @CedarsSinai made iPSCs from individuals w/ youn…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ShorterLab: iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates:…
RT @ShorterLab: iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates:…
RT @ShorterLab: iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates:…
RT @EricTopol: So much to learn about #Parkinsonsdisease, which is on a steep rise. Here a @CedarsSinai made iPSCs from individuals w/ youn…
RT @EricTopol: So much to learn about #Parkinsonsdisease, which is on a steep rise. Here a @CedarsSinai made iPSCs from individuals w/ youn…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ShorterLab: iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates:…
iPSC-derived midbrain dopaminergic neurons from patients with young-onset Parkinson’s disease exhibit molecular abnormalities, including elevated α-synuclein and lysosomal dysfunction, which can be normalized with phorbol ester treatment https://t.co/AbmGX
RT @ShorterLab: iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates:…
RT @EricTopol: So much to learn about #Parkinsonsdisease, which is on a steep rise. Here a @CedarsSinai made iPSCs from individuals w/ youn…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @EricTopol: So much to learn about #Parkinsonsdisease, which is on a steep rise. Here a @CedarsSinai made iPSCs from individuals w/ youn…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ArunSharmaPhD: Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years o…
RT @ESC_iPSC_News: Exciting research out today from @CedarsSinai in @NatureMedicine: iPSC modeling of young-onset #Parkinson’s disease reve…
Big time hiPSC disease modeling paper in @NatureMedicine from friends in Svendsen lab here at @CedarsSinai. 5+ years of work unraveling the mechanisms of young-onset Parkinson’s disease, and uncovering potential therapeutic targets along the way. 🧠 htt
RT @ESC_iPSC_News: Exciting research out today from @CedarsSinai in @NatureMedicine: iPSC modeling of young-onset #Parkinson’s disease reve…
RT @ESC_iPSC_News: Exciting research out today from @CedarsSinai in @NatureMedicine: iPSC modeling of young-onset #Parkinson’s disease reve…
RT @ESC_iPSC_News: Exciting research out today from @CedarsSinai in @NatureMedicine: iPSC modeling of young-onset #Parkinson’s disease reve…
Exciting research out today from @CedarsSinai in @NatureMedicine: iPSC modeling of young-onset #Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates. https://t.co/4ZcbJq8yQY
#iPSC modeling of young-onset #Parkinson disease reveals a molecular signature of disease and novel therapeutic candidates. So many therapeutic “candidates” and zero therapies.... @NatureMedicine @ScienceofPD @journal_PD https://t.co/XMJ3Zwd48z
RT @ShorterLab: iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates:…
iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates: https://t.co/JKJ3YCGyjq
RT @ScienceofPD: @CedarsSinai researchers generated IPS cells from YOPD individuals (with no known mutations), grew dopamine neurons which…
Really cool paper. I'd be curious to try drugs that specifically inc. #proteasome activity --> iPSC modeling of young-onset #Parkinsons disease reveals a molecular signature of disease and novel therapeutic candidates https://t.co/VXeKgMAsO6 @NatureMedi
@CedarsSinai researchers generated IPS cells from YOPD individuals (with no known mutations), grew dopamine neurons which showed accumulation of soluble α-synuclein & phosphorylated PKCα, & this phenotype was reduced by phorbol esters, such as PEP0
iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates https://t.co/K0CCGZTVQA https://t.co/tzPb2GiuYS