Exome sequencing in schizophrenia-affected parent–offspring trios reveals risk conferred by protein-coding de novo mutations

RT @PGCgenetics: Some of the earlier sequencing studies in established a role for ultra-rare and de novo mutations in increasing risk of #s…

Some of the earlier sequencing studies in established a role for ultra-rare and de novo mutations in increasing risk of #schizophrenia, with enrichment in neuronal genes and synaptic processes. https://t.co/Lb8J5gTqj6 https://t.co/279WyHfVtv

RT @MGHNeuroSci: Schizophrenia has some association with new genetic mutations. Studying ~2.8K parent-offspring trios, Daniel Howrigan, PhD…

RT @MGHNeuroSci: Schizophrenia has some association with new genetic mutations. Studying ~2.8K parent-offspring trios, Daniel Howrigan, PhD…

"The overlap in relative risk and gene set enrichment between trio and case–control designs so far strongly suggests that either approach will identify individual risk genes in larger samples." Analysis includes Swedish Hospital Discharge Register cohort.

Looks like you better get back to recruiting more trios @GeorgeKirov1 @ERees85 @MRCcardiff

RT @MGHNeuroSci: Schizophrenia has some association with new genetic mutations. Studying ~2.8K parent-offspring trios, Daniel Howrigan, PhD…

RT @MGHNeuroSci: Schizophrenia has some association with new genetic mutations. Studying ~2.8K parent-offspring trios, Daniel Howrigan, PhD…

Schizophrenia has some association with new genetic mutations. Studying ~2.8K parent-offspring trios, Daniel Howrigan, PhD, & Benjamin Neale, PhD, of Mass General & the @broadinstitute and colleagues show ~3.2-4K trios are needed for 80% detection

New analyses of de novo mutations from 1,695 schizophrenia-affected trios and 1,077 published schizophrenia-affected trios to better understand the contribution to schizophrenia risk. #neuroscience #brain #neuron #schizophrenia #genetics #denovomutations h

RT @WiringTheBrain: Two new exome sequencing studies both reinforce idea that rare mutations are important in schizophrenia etiology https:…

RT @WiringTheBrain: Two new exome sequencing studies both reinforce idea that rare mutations are important in schizophrenia etiology https:…

RT @WiringTheBrain: Two new exome sequencing studies both reinforce idea that rare mutations are important in schizophrenia etiology https:…

Two new exome sequencing studies both reinforce idea that rare mutations are important in schizophrenia etiology https://t.co/mlaph410n3 https://t.co/3CumkE0b7b https://t.co/kSj9X9lDLz

RT @dafil: de novo exonic variants explains a small fraction of the overall risk factor, pointing towards (our recent favourite) polygenic…

"...to a 3.15-fold higher rate than the mutation model expectation." https://t.co/h7W2duvl7I @shi_huang5

de novo exonic variants explains a small fraction of the overall risk factor, pointing towards (our recent favourite) polygenic score for risk calculation. #exome #Schizophrenia #polygenic https://t.co/G7mYIwLvmf

RT @emauryg: Empirical evidence that de-novo protein-coding mutations confer modest yet significant risk for Schizophrenia, relatively inde…

Exome sequencing in schizophrenia-affected parent-offspring trios reveals risk conferred by protein-coding de novo mutations. #amchelsinki #tutkimus https://t.co/EkIiNXHL23

Empirical evidence that de-novo protein-coding mutations confer modest yet significant risk for Schizophrenia, relatively independent from polygenic risk. https://t.co/swzxucZ1Gn https://t.co/Ki2h8rmvmX https://t.co/74iW6JmcpZ

RT @NatureNeuro: #Exome sequencing in #schizophrenia trios reveals only a small contribution towards overall risk from protein-coding de no…

#Exome sequencing in #schizophrenia trios reveals only a small contribution towards overall risk from protein-coding de novo mutations https://t.co/Ktsa5kyjJR https://t.co/ZqDccmW3VF

When you get new schizophrenia genomic papers, control + F for "DISC1" https://t.co/MgoN2TRbV9 https://t.co/efp18EdxRP

Exome sequencing in schizophrenia-affected parent–offspring trios reveals risk conferred by protein-coding de novo mutations - Nature Neuroscience via BrainSights for iOS https://t.co/iLYCTXcGMc