@JustRickard @SpeedWatkins An example: https://t.co/NO404YOdOv
Note that @imartincorena had observed a reduced mutation rate in evolutionary constrained E. coli genes already 10 years ago. https://t.co/SfTrK9Z2Ky [2/24] https://t.co/BLp7XkgDrI
It's interesting that I've found myself writing MCMC algorithms that mimic this approach - repeatedly propose changes to latent variables that have a smaller impact on the data fit, and occasionally propose changes to latent structure that drastically alte
This test was done by @imartincorena et al. They found certain genomic regions to be much less variable than others - after controlling for selection! The variability was lowest in essential genes: an "evolutionary risk management strategy" https://t.
@theAliceRoberts @PaulCarneyArts .. is more ‘determined’ than we thought to avoid harmful mutations and conserve genetic information? In fact, as I've just discovered, this line of research is not new https://t.co/vdblbKQSHC
@premal_shah The finding of lowered mutation rates in genes under purifying selection was made 10 years ago in a prokaryote. This prior finding is not made clear in the new article. Being found now in 2 kingdoms should help establish the idea. https://t.co
RT @PlantEvolution: Should have started this thread with big kudos to @imartincorena whose groundbreaking 2012 paper provided the first evi…
#needtoreadlist and this before the next one, I think
RT @PlantEvolution: Should have started this thread with big kudos to @imartincorena whose groundbreaking 2012 paper provided the first evi…
RT @PlantEvolution: Should have started this thread with big kudos to @imartincorena whose groundbreaking 2012 paper provided the first evi…
RT @PlantEvolution: Should have started this thread with big kudos to @imartincorena whose groundbreaking 2012 paper provided the first evi…
Should have started this thread with big kudos to @imartincorena whose groundbreaking 2012 paper provided the first evidence for essential genes in E. coli mutating less frequently, for which he had to endure lots of criticisms 🔥 https://t.co/SfTrK9Z2Ky
@rgatess This thinking around “hot and cold spots” of mutation in the genome has been around for awhile, no? https://t.co/ReZBRj6rYj
Evidence of non-random mutation in organisms, contradicting the theory of evolution https://t.co/StafZZU8Ix
@NimwegenLab Random question: do you think your observations explain local variability observed here: https://t.co/sowPG9Gen1? The original explanation (selected heterogeneity in mutation rate) seemed unlikely to me at the time... thanks
Not so random #evolution. Organism can modulate the local mutation rate between different sites within a genome https://t.co/9FIMBIOLFA https://t.co/VSRyuKGbOj
系統・集団的遺伝操作を用い、大腸菌の中立変異の頻度を調査した。その結果、高く発現する遺伝子・自然選択が働く領域で突然変異の頻度が低いことが分かった。これは突然変異の頻度を最適化する未知の機構の存在を示唆する。chishima https://t.co/8MelwCnT2J
Comment on Martincorena I (2012): Evidence of non-random mutation rates suggests an evolutionary risk management http://t.co/R2GUFAXx8K
Hmm interesting. Always thought mutation is selective, not random... Evidence of non-random mutation rates suggests http://t.co/FhdsqvB9sV
Hmm interesting. Always thought mutation is selective, not random... Evidence of non-random mutation rates suggests http://t.co/FhdsqvB9sV
.@HayleyNature @ColetteA #originofspecies quote sounds like what i'm saying...mutations aren't all THAT random, see: http://t.co/wDSx6oo6pO
@thedudekfc @dingodavesmith and this. http://t.co/caQYtEzMKU
Evidence of non-random mutation rates suggests an evo... [Nature. 2012] - PubMed - NCBI http://t.co/wDSx6oo6pO #COSMOS #ORIGINOFSPECIES
Evolution may not as random as conventional science would like to presume. http://t.co/HdUKg569n1
Evolution may not as random as conventional science would like to presume. http://t.co/HdUKg569n1
Evolution may not as random as conventional science would like to presume. http://t.co/joI2zPPm5f
これか。ただ状況証拠だけみたいだな/Evidence of non-random mutation rates suggests an evolutionary risk management strategy http://t.co/S8hgEJXo
RT @Graham_Coop: RT @Graham_Coop: .@VinJLynch the Lenski paper seems like a response to: http://t.co/EHi8F2ZX
.@VinJLynch the Lenski paper seems like a response to: http://t.co/EHi8F2ZX
RT @jrkelly: Evidence of non-random mutation rates suggests an evolutionary risk management strategy : Nature http://t.co/5gF4Xfx3
Evidence of non-random mutation rates. Nature paper: http://t.co/4TiQufq4
そりゃこうなるんだろうけどもこういうの見れたら面白いよなぁー.先輩がご飯の時に教えてくれた.http://t.co/hUylgozJ
Evidence of non-random mutation rates suggests an evolutionary risk management strategy : Nature http://t.co/5gF4Xfx3
Evidence of non-random mutation rates suggests an evolutionary risk management strategy http://t.co/NO2F7FF4
http://t.co/k4nCIz64 the neutral mutation rate varies by more than an order of magnitude across 2,659 genes across 34 E. coli genomes 大腸菌
@iizak mira esto mira esto!!! chance en veces... http://t.co/nDoeEkjf
進化理論の3つの原理:「形質が遺伝すること」,「形質に突然変異がランダムに起こること」,「ランダムで起こった形質が自然選択されること」.でも実際は突然変異はランダムではなく,遺伝子によって突然変異の起こりやすさは違っているって話.http://t.co/aWDxHsA4
Evidence of non-random mutation rates suggests an evolutionary risk management strategy http://t.co/CEJ1SoZ1
Evidence of non-random mutation rates suggests an evolutionary risk management strategy http://t.co/EUiAcsES #evolution #science #nature
Very cool! http://t.co/2rXyfqO8
RT @RJABuggs: Evidence of non-random mutation rates suggests an evolutionary risk management strategy http://t.co/EnI7q95U
Evidence of non-random mutation rates suggests an evolutionary risk management strategy http://t.co/EnI7q95U
Evidence of non-random mutation rates suggests an evolutionary risk management strategy in E. coli http://t.co/u301uda1
Evolutionary risk management http://t.co/qNGF3JVR
¡Enhorabuena a Iñigo Martincorena, graduado de @UNAV que hace la tesis en Cambridge, por su primer paper en Nature! http://t.co/WMgy2T6k
Evidence of non-random mutation rates suggests an evolutionary risk management strategy http://t.co/ehIaBtup
RT @RosieRedfield Shades of John Cairns and directed mutations! & confusion about rates of mutation and substitutions. http://t.co/QvgRmtPr
and I'll wager $100 it can't: RT @RosieRedfield: I doubt selection optimizes point mutation rates to gene functions. http://t.co/age2L0fY
Shades of John Cairns and directed mutations! I doubt that selection optimizes point mutation rates to gene functions. http://t.co/9F0BX6ds
RT @druvus: Evidence of non-random mutation rates suggests an evolutionary risk management strategy in bacteria http://t.co/vX2dqpp9 #ecoli #evolution
RT @NatureMagazine: Evidence of non-random mutation rates suggests an evolutionary risk management strategy: http://t.co/aATdxyE3
Evidence of non-random mutation rates suggests an evolutionary risk management strategy http://t.co/rGSRBteL
Now we can no more say mutations occur randomly! http://t.co/wf3rYUow
RT @NatureMagazine: Evidence of non-random mutation rates suggests an evolutionary risk management strategy: http://t.co/aATdxyE3
RT @NatureRevMicro: Mutation rate variation is non-random across the E. coli genome (via Nature) http://t.co/ILqZ4h84 (£) #mondaymicro
RT @NatureRevMicro: Mutation rate variation is non-random across the E. coli genome (via Nature) http://t.co/ILqZ4h84 (£) #mondaymicro
Evidence of non-random mutation rates suggests an evolutionary risk management strategy http://t.co/rQ88xCSg
RT @NatureRevMicro: Mutation rate variation is non-random across the E. coli genome (via Nature) http://t.co/ILqZ4h84 (£) #mondaymicro
Evidence of non-random mutation rates suggests an evolutionary risk management strategy: http://t.co/aATdxyE3
Evidence of non-random mutation rates suggests an evolutionary risk management strategy in bacteria http://t.co/vX2dqpp9 #ecoli #evolution
RT @NatureRevMicro: Mutation rate variation is non-random across the E. coli genome (via Nature) http://t.co/ILqZ4h84 (£) #mondaymicro
RT @NatureRevMicro: Mutation rate variation is non-random across the E. coli genome (via Nature) http://t.co/ILqZ4h84 (£) #mondaymicro
RT @NatureRevMicro: Mutation rate variation is non-random across the E. coli genome (via Nature) http://t.co/ILqZ4h84 (£) #mondaymicro
Mutation rate variation is non-random across the E. coli genome (via Nature) http://t.co/ILqZ4h84 (£) #mondaymicro