| Title |
Ancient horizontal transfers of retrotransposons between birds and ancestors of human pathogenic nematodes
|
|---|---|
| Published in |
Nature Communications, April 2016
|
| DOI | 10.1038/ncomms11396 |
| Pubmed ID | |
| Authors |
Alexander Suh, Christopher C. Witt, Juliana Menger, Keren R. Sadanandan, Lars Podsiadlowski, Michael Gerth, Anne Weigert, Jimmy A. McGuire, Joann Mudge, Scott V. Edwards, Frank E. Rheindt |
| Abstract |
Parasite host switches may trigger disease emergence, but prehistoric host ranges are often unknowable. Lymphatic filariasis and loiasis are major human diseases caused by the insect-borne filarial nematodes Brugia, Wuchereria and Loa. Here we show that the genomes of these nematodes and seven tropical bird lineages exclusively share a novel retrotransposon, AviRTE, resulting from horizontal transfer (HT). AviRTE subfamilies exhibit 83-99% nucleotide identity between genomes, and their phylogenetic distribution, paleobiogeography and invasion times suggest that HTs involved filarial nematodes. The HTs between bird and nematode genomes took place in two pantropical waves, >25-22 million years ago (Myr ago) involving the Brugia/Wuchereria lineage and >20-17 Myr ago involving the Loa lineage. Contrary to the expectation from the mammal-dominated host range of filarial nematodes, we hypothesize that these major human pathogens may have independently evolved from bird endoparasites that formerly infected the global breadth of avian biodiversity. |
X Demographics
The data shown below were collected from the profiles of 113 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 27 | 24% |
| United Kingdom | 14 | 12% |
| Canada | 6 | 5% |
| Sweden | 4 | 4% |
| Australia | 3 | 3% |
| Bosnia and Herzegovina | 2 | 2% |
| Italy | 2 | 2% |
| Bolivia, Plurinational State of | 2 | 2% |
| Mexico | 2 | 2% |
| Other | 14 | 12% |
| Unknown | 37 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 54 | 48% |
| Members of the public | 53 | 47% |
| Science communicators (journalists, bloggers, editors) | 6 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | 3% |
| Netherlands | 1 | 1% |
| France | 1 | 1% |
| Austria | 1 | 1% |
| Italy | 1 | 1% |
| Czechia | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 80 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 17% |
| Student > Ph. D. Student | 14 | 16% |
| Researcher | 13 | 15% |
| Student > Master | 10 | 11% |
| Other | 8 | 9% |
| Other | 23 | 26% |
| Unknown | 6 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 51% |
| Biochemistry, Genetics and Molecular Biology | 12 | 13% |
| Medicine and Dentistry | 4 | 4% |
| Environmental Science | 3 | 3% |
| Veterinary Science and Veterinary Medicine | 3 | 3% |
| Other | 9 | 10% |
| Unknown | 13 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 232. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2022.
All research outputs
#166,525
of 25,706,302 outputs
Outputs from Nature Communications
#2,377
of 58,155 outputs
Outputs of similar age
#3,035
of 314,442 outputs
Outputs of similar age from Nature Communications
#41
of 820 outputs
Altmetric has tracked 25,706,302 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,155 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.3. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,442 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 820 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.