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Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice

Overview of attention for article published in Nature Communications, September 2019
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

news
5 news outlets
twitter
41 X users
facebook
3 Facebook pages

Citations

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143 Dimensions

Readers on

mendeley
218 Mendeley
Title
Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice
Published in
Nature Communications, September 2019
DOI 10.1038/s41467-019-11866-7
Pubmed ID
Authors

Claudia P. Figueiredo, Fernanda G. Q. Barros-Aragão, Rômulo L. S. Neris, Paula S. Frost, Carolina Soares, Isis N. O. Souza, Julianna D. Zeidler, Daniele C. Zamberlan, Virginia L. de Sousa, Amanda S. Souza, André Luis A. Guimarães, Maria Bellio, Jorge Marcondes de Souza, Soniza V. Alves-Leon, Gilda A. Neves, Heitor A. Paula-Neto, Newton G. Castro, Fernanda G. De Felice, Iranaia Assunção-Miranda, Julia R. Clarke, Andrea T. Da Poian, Sergio T. Ferreira

Abstract

Neurological complications affecting the central nervous system have been reported in adult patients infected by Zika virus (ZIKV) but the underlying mechanisms remain unknown. Here, we report that ZIKV replicates in human and mouse adult brain tissue, targeting mature neurons. ZIKV preferentially targets memory-related brain regions, inhibits hippocampal long-term potentiation and induces memory impairment in adult mice. TNF-α upregulation, microgliosis and upregulation of complement system proteins, C1q and C3, are induced by ZIKV infection. Microglia are found to engulf hippocampal presynaptic terminals during acute infection. Neutralization of TNF-α signaling, blockage of microglial activation or of C1q/C3 prevent synapse and memory impairment in ZIKV-infected mice. Results suggest that ZIKV induces synapse and memory dysfunction via aberrant activation of TNF-α, microglia and complement. Our findings establish a mechanism by which ZIKV affects the adult brain, and point to the need of evaluating cognitive deficits as a potential comorbidity in ZIKV-infected adults.

X Demographics

X Demographics

The data shown below were collected from the profiles of 41 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 218 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 218 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 40 18%
Student > Ph. D. Student 31 14%
Researcher 25 11%
Student > Master 25 11%
Student > Doctoral Student 11 5%
Other 33 15%
Unknown 53 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 32 15%
Neuroscience 31 14%
Agricultural and Biological Sciences 23 11%
Immunology and Microbiology 23 11%
Medicine and Dentistry 15 7%
Other 29 13%
Unknown 65 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 61. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2021.
All research outputs
#707,028
of 25,551,063 outputs
Outputs from Nature Communications
#12,160
of 57,603 outputs
Outputs of similar age
#14,782
of 351,155 outputs
Outputs of similar age from Nature Communications
#300
of 1,462 outputs
Altmetric has tracked 25,551,063 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 57,603 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 351,155 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1,462 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.