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| Title |
Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice
|
|---|---|
| Published in |
Nature Communications, September 2019
|
| DOI | 10.1038/s41467-019-11866-7 |
| Pubmed ID | |
| Authors |
Claudia P. Figueiredo, Fernanda G. Q. Barros-Aragão, Rômulo L. S. Neris, Paula S. Frost, Carolina Soares, Isis N. O. Souza, Julianna D. Zeidler, Daniele C. Zamberlan, Virginia L. de Sousa, Amanda S. Souza, André Luis A. Guimarães, Maria Bellio, Jorge Marcondes de Souza, Soniza V. Alves-Leon, Gilda A. Neves, Heitor A. Paula-Neto, Newton G. Castro, Fernanda G. De Felice, Iranaia Assunção-Miranda, Julia R. Clarke, Andrea T. Da Poian, Sergio T. Ferreira |
| Abstract |
Neurological complications affecting the central nervous system have been reported in adult patients infected by Zika virus (ZIKV) but the underlying mechanisms remain unknown. Here, we report that ZIKV replicates in human and mouse adult brain tissue, targeting mature neurons. ZIKV preferentially targets memory-related brain regions, inhibits hippocampal long-term potentiation and induces memory impairment in adult mice. TNF-α upregulation, microgliosis and upregulation of complement system proteins, C1q and C3, are induced by ZIKV infection. Microglia are found to engulf hippocampal presynaptic terminals during acute infection. Neutralization of TNF-α signaling, blockage of microglial activation or of C1q/C3 prevent synapse and memory impairment in ZIKV-infected mice. Results suggest that ZIKV induces synapse and memory dysfunction via aberrant activation of TNF-α, microglia and complement. Our findings establish a mechanism by which ZIKV affects the adult brain, and point to the need of evaluating cognitive deficits as a potential comorbidity in ZIKV-infected adults. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 10% |
| Brazil | 4 | 10% |
| France | 3 | 8% |
| Germany | 1 | 3% |
| Switzerland | 1 | 3% |
| Canada | 1 | 3% |
| Poland | 1 | 3% |
| Portugal | 1 | 3% |
| Unknown | 24 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 60% |
| Scientists | 12 | 30% |
| Practitioners (doctors, other healthcare professionals) | 2 | 5% |
| Science communicators (journalists, bloggers, editors) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 229 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 229 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 42 | 18% |
| Student > Ph. D. Student | 35 | 15% |
| Student > Master | 25 | 11% |
| Researcher | 24 | 10% |
| Student > Doctoral Student | 11 | 5% |
| Other | 35 | 15% |
| Unknown | 57 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 35 | 15% |
| Neuroscience | 33 | 14% |
| Agricultural and Biological Sciences | 24 | 10% |
| Immunology and Microbiology | 24 | 10% |
| Medicine and Dentistry | 15 | 7% |
| Other | 29 | 13% |
| Unknown | 69 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 60. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2021.
All research outputs
#757,638
of 26,574,355 outputs
Outputs from Nature Communications
#13,023
of 62,371 outputs
Outputs of similar age
#15,176
of 354,134 outputs
Outputs of similar age from Nature Communications
#307
of 1,463 outputs
Altmetric has tracked 26,574,355 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 62,371 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.1. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,134 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1,463 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.