| Title |
Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential
|
|---|---|
| Published in |
Nature Communications, March 2016
|
| DOI | 10.1038/ncomms11165 |
| Pubmed ID | |
| Authors |
Helen Bolton, Sarah J. L. Graham, Niels Van der Aa, Parveen Kumar, Koen Theunis, Elia Fernandez Gallardo, Thierry Voet, Magdalena Zernicka-Goetz |
| Abstract |
Most human pre-implantation embryos are mosaics of euploid and aneuploid cells. To determine the fate of aneuploid cells and the developmental potential of mosaic embryos, here we generate a mouse model of chromosome mosaicism. By treating embryos with a spindle assembly checkpoint inhibitor during the four- to eight-cell division, we efficiently generate aneuploid cells, resulting in embryo death during peri-implantation development. Live-embryo imaging and single-cell tracking in chimeric embryos, containing aneuploid and euploid cells, reveal that the fate of aneuploid cells depends on lineage: aneuploid cells in the fetal lineage are eliminated by apoptosis, whereas those in the placental lineage show severe proliferative defects. Overall, the proportion of aneuploid cells is progressively depleted from the blastocyst stage onwards. Finally, we show that mosaic embryos have full developmental potential, provided they contain sufficient euploid cells, a finding of significance for the assessment of embryo vitality in the clinic. |
X Demographics
The data shown below were collected from the profiles of 38 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 7 | 18% |
| United States | 6 | 16% |
| United Kingdom | 3 | 8% |
| Australia | 2 | 5% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| Panama | 1 | 3% |
| Saudi Arabia | 1 | 3% |
| Germany | 1 | 3% |
| Unknown | 16 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 28 | 74% |
| Scientists | 7 | 18% |
| Practitioners (doctors, other healthcare professionals) | 2 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 325 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | <1% |
| United Kingdom | 1 | <1% |
| Poland | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 320 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 52 | 16% |
| Researcher | 45 | 14% |
| Student > Bachelor | 38 | 12% |
| Student > Master | 34 | 10% |
| Student > Doctoral Student | 15 | 5% |
| Other | 55 | 17% |
| Unknown | 86 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 102 | 31% |
| Agricultural and Biological Sciences | 64 | 20% |
| Medicine and Dentistry | 44 | 14% |
| Nursing and Health Professions | 4 | 1% |
| Engineering | 4 | 1% |
| Other | 15 | 5% |
| Unknown | 92 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 308. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2023.
All research outputs
#105,341
of 24,547,718 outputs
Outputs from Nature Communications
#1,494
of 52,858 outputs
Outputs of similar age
#1,989
of 306,109 outputs
Outputs of similar age from Nature Communications
#26
of 820 outputs
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