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Direct synthesis of Z-alkenyl halides through catalytic cross-metathesis

Overview of attention for article published in Nature, March 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

4 news outlets
2 blogs
7 tweeters
1 patent
2 Facebook pages
1 Wikipedia page
1 Redditor


113 Dimensions

Readers on

150 Mendeley
Direct synthesis of Z-alkenyl halides through catalytic cross-metathesis
Published in
Nature, March 2016
DOI 10.1038/nature17396
Pubmed ID

Ming Joo Koh, Thach T. Nguyen, Hanmo Zhang, Richard R. Schrock, Amir H. Hoveyda


Olefin metathesis has had a large impact on modern organic chemistry, but important shortcomings remain: for example, the lack of efficient processes that can be used to generate acyclic alkenyl halides. Halo-substituted ruthenium carbene complexes decompose rapidly or deliver low activity and/or minimal stereoselectivity, and our understanding of the corresponding high-oxidation-state systems is limited. Here we show that previously unknown halo-substituted molybdenum alkylidene species are exceptionally reactive and are able to participate in high-yielding olefin metathesis reactions that afford acyclic 1,2-disubstituted Z-alkenyl halides. Transformations are promoted by small amounts of a catalyst that is generated in situ and used with unpurified, commercially available and easy-to-handle liquid 1,2-dihaloethene reagents, and proceed to high conversion at ambient temperature within four hours. We obtain many alkenyl chlorides, bromides and fluorides in up to 91 per cent yield and complete Z selectivity. This method can be used to synthesize biologically active compounds readily and to perform site- and stereoselective fluorination of complex organic molecules.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 <1%
Germany 1 <1%
Switzerland 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
China 1 <1%
Estonia 1 <1%
Japan 1 <1%
United States 1 <1%
Other 0 0%
Unknown 141 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 38 25%
Researcher 29 19%
Student > Bachelor 21 14%
Student > Master 19 13%
Professor > Associate Professor 12 8%
Other 22 15%
Unknown 9 6%
Readers by discipline Count As %
Chemistry 126 84%
Computer Science 2 1%
Agricultural and Biological Sciences 2 1%
Biochemistry, Genetics and Molecular Biology 2 1%
Materials Science 2 1%
Other 1 <1%
Unknown 15 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 52. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2019.
All research outputs
of 14,794,860 outputs
Outputs from Nature
of 73,239 outputs
Outputs of similar age
of 264,276 outputs
Outputs of similar age from Nature
of 1,024 outputs
Altmetric has tracked 14,794,860 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 73,239 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 82.1. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,276 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1,024 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.