| Title |
Liver function predicts survival in patients undergoing extracorporeal membrane oxygenation following cardiovascular surgery
|
|---|---|
| Published in |
Critical Care, March 2016
|
| DOI | 10.1186/s13054-016-1242-4 |
| Pubmed ID | |
| Authors |
Christian Roth, Lore Schrutka, Christina Binder, Lukas Kriechbaumer, Gottfried Heinz, Irene M. Lang, Gerald Maurer, Herbert Koinig, Barbara Steinlechner, Alexander Niessner, Klaus Distelmaier, Georg Goliasch |
| Abstract |
Extracorporeal membrane oxygenation (ECMO) represents a valuable and rapidly evolving therapeutic option in patients with severe heart or lung failure following cardiovascular surgery. However, despite significant advances in ECMO techniques and management, prognosis remains poor and accurate risk stratification challenging. We therefore evaluated the predictive value of liver function variables on all-cause mortality in patients undergoing venoarterial ECMO support after cardiovascular surgery. We included into our single-center registry a total of 240 patients undergoing venoarterial ECMO therapy following cardiovascular surgery at a university-affiliated tertiary care center. The median follow-up was 37 months (interquartile range 19-67 months), and a total of 156 patients (65 %) died. Alkaline phosphatase and total bilirubin were the strongest predictors for 30-day mortality, with adjusted hazard ratios (HRs) per 1-standard deviation increase of 1.36 (95 % confidence interval [CI] 1.10-1.68; P = 0.004) and 1.22 (95 % CI 1.07-1.40; P = 0.004), respectively. The observed associations persisted for long-term mortality, with adjusted HRs of 1.27 (95 % CI 1.03-1.56; P = 0.023) for alkaline phosphatase and 1.22 (95 % CI 1.07-1.39; P = 0.003) for total bilirubin. The present study demonstrates that elevated values of alkaline phosphatase and total bilirubin are sensitive parameters for predicting the short-term and long-term outcomes of ECMO patients. |
X Demographics
The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 33% |
| Spain | 2 | 6% |
| United Kingdom | 2 | 6% |
| Brazil | 1 | 3% |
| Grenada | 1 | 3% |
| Saudi Arabia | 1 | 3% |
| Japan | 1 | 3% |
| Netherlands | 1 | 3% |
| Colombia | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 11 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 25 | 76% |
| Practitioners (doctors, other healthcare professionals) | 5 | 15% |
| Science communicators (journalists, bloggers, editors) | 2 | 6% |
| Scientists | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 58 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 12% |
| Professor > Associate Professor | 6 | 10% |
| Student > Bachelor | 6 | 10% |
| Student > Doctoral Student | 5 | 9% |
| Other | 5 | 9% |
| Other | 11 | 19% |
| Unknown | 18 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 52% |
| Nursing and Health Professions | 2 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Arts and Humanities | 1 | 2% |
| Chemical Engineering | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 22 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2018.
All research outputs
#1,808,994
of 25,374,647 outputs
Outputs from Critical Care
#1,611
of 6,554 outputs
Outputs of similar age
#29,145
of 314,372 outputs
Outputs of similar age from Critical Care
#44
of 87 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has done well, scoring higher than 75% of its peers.
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We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.