| Title |
Towards single-molecule nanomechanical mass spectrometry
|
|---|---|
| Published in |
Nature Nanotechnology, June 2009
|
| DOI | 10.1038/nnano.2009.152 |
| Pubmed ID | |
| Authors |
A. K. Naik, M. S. Hanay, W. K. Hiebert, X. L. Feng, M. L. Roukes |
| Abstract |
Mass spectrometry provides rapid and quantitative identification of protein species with relatively low sample consumption. The trend towards biological analysis at increasingly smaller scales, ultimately down to the volume of an individual cell, continues, and mass spectrometry with a sensitivity of a few to single molecules will be necessary. Nanoelectromechanical systems provide unparalleled mass sensitivity, which is now sufficient for the detection of individual molecular species in real time. Here, we report the first demonstration of mass spectrometry based on single biological molecule detection with a nanoelectromechanical system. In our nanoelectromechanical-mass spectrometry system, nanoparticles and protein species are introduced by electrospray injection from the fluid phase in ambient conditions into vacuum, and are subsequently delivered to the nanoelectromechanical system detector by hexapole ion optics. Precipitous frequency shifts, proportional to the mass, are recorded in real time as analytes adsorb, one by one, onto a phase-locked, ultrahigh-frequency nanoelectromechanical resonator. These first nanoelectromechanical system-mass spectrometry spectra, obtained with modest mass sensitivity from only several hundred mass adsorption events, presage the future capabilities of this approach. We also outline the substantial improvements that are feasible in the near term, some of which are unique to nanoelectromechanical system based-mass spectrometry. |
Mendeley readers
The data shown below were compiled from readership statistics for 453 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 1% |
| United Kingdom | 5 | 1% |
| Germany | 4 | <1% |
| France | 3 | <1% |
| Canada | 3 | <1% |
| Switzerland | 2 | <1% |
| India | 2 | <1% |
| Australia | 1 | <1% |
| Israel | 1 | <1% |
| Other | 8 | 2% |
| Unknown | 418 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 159 | 35% |
| Researcher | 85 | 19% |
| Student > Master | 53 | 12% |
| Professor > Associate Professor | 25 | 6% |
| Professor | 22 | 5% |
| Other | 51 | 11% |
| Unknown | 58 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 129 | 28% |
| Physics and Astronomy | 125 | 28% |
| Agricultural and Biological Sciences | 39 | 9% |
| Materials Science | 33 | 7% |
| Chemistry | 29 | 6% |
| Other | 27 | 6% |
| Unknown | 71 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2023.
All research outputs
#1,915,800
of 23,056,273 outputs
Outputs from Nature Nanotechnology
#1,396
of 3,424 outputs
Outputs of similar age
#6,522
of 112,228 outputs
Outputs of similar age from Nature Nanotechnology
#2
of 26 outputs
Altmetric has tracked 23,056,273 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,424 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.2. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 112,228 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.