| Title |
Genomic diversity of EPEC associated with clinical presentations of differing severity
|
|---|---|
| Published in |
Nature Microbiology, January 2016
|
| DOI | 10.1038/nmicrobiol.2015.14 |
| Pubmed ID | |
| Authors |
Tracy H. Hazen, Michael S. Donnenberg, Sandra Panchalingam, Martin Antonio, Anowar Hossain, Inacio Mandomando, John Benjamin Ochieng, Thandavarayan Ramamurthy, Boubou Tamboura, Shahida Qureshi, Farheen Quadri, Anita Zaidi, Karen L. Kotloff, Myron M. Levine, Eileen M. Barry, James B. Kaper, David A. Rasko, James P. Nataro |
| Abstract |
Enteropathogenic Escherichia coli (EPEC) are diarrhoeagenic E. coli, and are a significant cause of gastrointestinal illness among young children in developing countries. Typical EPEC are identified by the presence of the bundle-forming pilus encoded by a virulence plasmid, which has been linked to an increased severity of illness, while atypical EPEC lack this feature. Comparative genomics of 70 total EPEC from lethal (LI), non-lethal symptomatic (NSI) or asymptomatic (AI) cases of diarrhoeal illness in children enrolled in the Global Enteric Multicenter Study was used to investigate the genomic differences in EPEC isolates obtained from individuals with various clinical outcomes. A comparison of the genomes of isolates from different clinical outcomes identified genes that were significantly more prevalent in EPEC isolates of symptomatic and lethal outcomes than in EPEC isolates of asymptomatic outcomes. These EPEC isolates exhibited previously unappreciated phylogenomic diversity and combinations of virulence factors. These comparative results highlight the diversity of the pathogen, as well as the complexity of the EPEC virulence factor repertoire. |
X Demographics
The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 7 | 21% |
| United States | 3 | 9% |
| United Kingdom | 2 | 6% |
| Australia | 2 | 6% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| Sweden | 1 | 3% |
| France | 1 | 3% |
| Bangladesh | 1 | 3% |
| Malawi | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 15 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 17 | 50% |
| Members of the public | 16 | 47% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 2% |
| Unknown | 114 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 16% |
| Researcher | 18 | 16% |
| Student > Master | 14 | 12% |
| Student > Doctoral Student | 11 | 9% |
| Student > Bachelor | 7 | 6% |
| Other | 21 | 18% |
| Unknown | 26 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 22 | 19% |
| Agricultural and Biological Sciences | 20 | 17% |
| Immunology and Microbiology | 18 | 16% |
| Medicine and Dentistry | 11 | 9% |
| Engineering | 5 | 4% |
| Other | 8 | 7% |
| Unknown | 32 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 58. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2016.
All research outputs
#631,156
of 23,023,224 outputs
Outputs from Nature Microbiology
#660
of 1,726 outputs
Outputs of similar age
#12,552
of 394,805 outputs
Outputs of similar age from Nature Microbiology
#17
of 55 outputs
Altmetric has tracked 23,023,224 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,726 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 93.7. This one has gotten more attention than average, scoring higher than 61% of its peers.
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We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.