| Title |
Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18–22 months
|
|---|---|
| Published in |
Pediatric Research, September 2018
|
| DOI | 10.1038/s41390-018-0174-x |
| Pubmed ID | |
| Authors |
Lina F Chalak, Kim-Anh Nguyen, Chatchay Prempunpong, Roy Heyne, Sudhin Thayyil, Seetha Shankaran, Abbot R. Laptook, Nancy Rollins, Athina Pappas, Louise Koclas, Birju Shah, Paolo Montaldo, Benyachalee Techasaensiri, Pablo J. Sánchez, Guilherme Sant’Anna |
| Abstract |
Studies of early childhood outcomes of mild hypoxic-ischemic encephalopathy (HIE) identified in the first 6 h of life are lacking. To evaluate neurodevelopmental outcomes at 18-22 months of PRIME study. Multicenter, prospective study of mild HIE defined as ≥1 abnormality using the modified Sarnat within 6 h of birth and not meeting cooling criteria. Primary outcome was disability with mild: Bayley III cognitive 70-84 or ≥85 and either Gross Motor Function Classification System (GMFCS) 1 or 2, seizures, or hearing deficit; moderate: cognitive 70-84 and either GMFCS 2, seizures, or hearing deficit; severe: cognitive <70, GMFCS 3-5. Of the 63 infants enrolled, 51 (81%) were evaluated at 19 ± 2 months and 43 (68%) completed Bayley III. Of the 43 infants, 7 (16%) were diagnosed with disability, including 1 cerebral palsy and 2 autism. Bayley scores < 85 in either cognition, motor, or language were detected in 17 (40%): 14 (32%) language, 7 (16%) cognitive, and 6 (14%) motor domain. Infants with disability had more abnormalities on discharge examination and brain MRI, with longer hospital stay (p < 0.001). In this contemporary untreated cohort of mild HIE, disability occurred in 16% of infants at 18-22 months. |
X Demographics
The data shown below were collected from the profiles of 61 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 18% |
| United Kingdom | 11 | 18% |
| Spain | 5 | 8% |
| Australia | 3 | 5% |
| South Africa | 2 | 3% |
| Denmark | 1 | 2% |
| Brazil | 1 | 2% |
| Italy | 1 | 2% |
| Ireland | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 22 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 36 | 59% |
| Scientists | 12 | 20% |
| Practitioners (doctors, other healthcare professionals) | 9 | 15% |
| Science communicators (journalists, bloggers, editors) | 4 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 136 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 18 | 13% |
| Student > Master | 18 | 13% |
| Student > Ph. D. Student | 12 | 9% |
| Researcher | 11 | 8% |
| Student > Bachelor | 10 | 7% |
| Other | 28 | 21% |
| Unknown | 39 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 44 | 32% |
| Neuroscience | 14 | 10% |
| Nursing and Health Professions | 8 | 6% |
| Psychology | 7 | 5% |
| Biochemistry, Genetics and Molecular Biology | 3 | 2% |
| Other | 11 | 8% |
| Unknown | 49 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2021.
All research outputs
#1,114,281
of 25,654,806 outputs
Outputs from Pediatric Research
#185
of 5,618 outputs
Outputs of similar age
#23,409
of 348,809 outputs
Outputs of similar age from Pediatric Research
#13
of 109 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,618 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done particularly well, scoring higher than 96% of its peers.
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