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A threading receptor for polysaccharides

Overview of attention for article published in Nature Chemistry, November 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

24 tweeters

Readers on

43 Mendeley
A threading receptor for polysaccharides
Published in
Nature Chemistry, November 2015
DOI 10.1038/nchem.2395
Pubmed ID

Tiddo J. Mooibroek, Juan M. Casas-Solvas, Robert L. Harniman, Charles M. Renney, Tom S. Carter, Matthew P. Crump, Anthony P. Davis


Cellulose, chitin and related polysaccharides are key renewable sources of organic molecules and materials. However, poor solubility tends to hamper their exploitation. Synthetic receptors could aid dissolution provided they are capable of cooperative action, for example by multiple threading on a single polysaccharide molecule. Here we report a synthetic receptor designed to form threaded complexes (polypseudorotaxanes) with these natural polymers. The receptor binds fragments of the polysaccharides in aqueous solution with high affinities (Ka up to 19,000 M(-1)), and is shown-by nuclear Overhauser effect spectroscopy-to adopt the threading geometry. Evidence from induced circular dichroism and atomic force microscopy implies that the receptor also forms polypseudorotaxanes with cellulose and its polycationic analogue chitosan. The results hold promise for polysaccharide solubilization under mild conditions, as well as for new approaches to the design of biologically active molecules.

Twitter Demographics

The data shown below were collected from the profiles of 24 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Netherlands 1 2%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 28%
Researcher 8 19%
Student > Master 7 16%
Student > Bachelor 4 9%
Professor > Associate Professor 4 9%
Other 8 19%
Readers by discipline Count As %
Chemistry 33 77%
Unspecified 4 9%
Agricultural and Biological Sciences 2 5%
Chemical Engineering 1 2%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 2 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
of 11,383,515 outputs
Outputs from Nature Chemistry
of 1,949 outputs
Outputs of similar age
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Outputs of similar age from Nature Chemistry
of 67 outputs
Altmetric has tracked 11,383,515 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,949 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 308,980 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.