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A threading receptor for polysaccharides

Overview of attention for article published in Nature Chemistry, November 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
20 tweeters

Citations

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98 Dimensions

Readers on

mendeley
74 Mendeley
Title
A threading receptor for polysaccharides
Published in
Nature Chemistry, November 2015
DOI 10.1038/nchem.2395
Pubmed ID
Authors

Tiddo J. Mooibroek, Juan M. Casas-Solvas, Robert L. Harniman, Charles M. Renney, Tom S. Carter, Matthew P. Crump, Anthony P. Davis

Abstract

Cellulose, chitin and related polysaccharides are key renewable sources of organic molecules and materials. However, poor solubility tends to hamper their exploitation. Synthetic receptors could aid dissolution provided they are capable of cooperative action, for example by multiple threading on a single polysaccharide molecule. Here we report a synthetic receptor designed to form threaded complexes (polypseudorotaxanes) with these natural polymers. The receptor binds fragments of the polysaccharides in aqueous solution with high affinities (Ka up to 19,000 M(-1)), and is shown-by nuclear Overhauser effect spectroscopy-to adopt the threading geometry. Evidence from induced circular dichroism and atomic force microscopy implies that the receptor also forms polypseudorotaxanes with cellulose and its polycationic analogue chitosan. The results hold promise for polysaccharide solubilization under mild conditions, as well as for new approaches to the design of biologically active molecules.

Twitter Demographics

The data shown below were collected from the profiles of 20 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
Germany 1 1%
Unknown 72 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 26%
Researcher 12 16%
Student > Master 10 14%
Professor > Associate Professor 6 8%
Student > Bachelor 5 7%
Other 7 9%
Unknown 15 20%
Readers by discipline Count As %
Chemistry 48 65%
Biochemistry, Genetics and Molecular Biology 3 4%
Agricultural and Biological Sciences 2 3%
Physics and Astronomy 1 1%
Neuroscience 1 1%
Other 2 3%
Unknown 17 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
#1,984,598
of 17,606,952 outputs
Outputs from Nature Chemistry
#1,462
of 2,596 outputs
Outputs of similar age
#46,392
of 373,993 outputs
Outputs of similar age from Nature Chemistry
#31
of 56 outputs
Altmetric has tracked 17,606,952 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,596 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.1. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 373,993 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.