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Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia

Overview of attention for article published in Nature Chemistry, November 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

4 news outlets
12 X users


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112 Mendeley
Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia
Published in
Nature Chemistry, November 2015
DOI 10.1038/nchem.2384
Pubmed ID

Hongyu Li, Hennie Valkenier, Luke W. Judd, Peter R. Brotherhood, Sabir Hussain, James A. Cooper, Ondřej Jurček, Hazel A. Sparkes, David N. Sheppard, Anthony P. Davis


Transmembrane anion transporters (anionophores) have potential for new modes of biological activity, including therapeutic applications. In particular they might replace the activity of defective anion channels in conditions such as cystic fibrosis. However, data on the biological effects of anionophores are scarce, and it remains uncertain whether such molecules are fundamentally toxic. Here, we report a biological study of an extensive series of powerful anion carriers. Fifteen anionophores were assayed in single cells by monitoring anion transport in real time through fluorescence emission from halide-sensitive yellow fluorescent protein. A bis-(p-nitrophenyl)ureidodecalin shows especially promising activity, including deliverability, potency and persistence. Electrophysiological tests show strong effects in epithelia, close to those of natural anion channels. Toxicity assays yield negative results in three cell lines, suggesting that promotion of anion transport may not be deleterious to cells. We therefore conclude that synthetic anion carriers are realistic candidates for further investigation as treatments for cystic fibrosis.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Unknown 111 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 33%
Student > Master 18 16%
Student > Bachelor 15 13%
Researcher 9 8%
Professor > Associate Professor 6 5%
Other 9 8%
Unknown 18 16%
Readers by discipline Count As %
Chemistry 61 54%
Biochemistry, Genetics and Molecular Biology 9 8%
Agricultural and Biological Sciences 8 7%
Pharmacology, Toxicology and Pharmaceutical Science 5 4%
Medicine and Dentistry 5 4%
Other 3 3%
Unknown 21 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 38. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2016.
All research outputs
of 24,588,574 outputs
Outputs from Nature Chemistry
of 3,233 outputs
Outputs of similar age
of 290,772 outputs
Outputs of similar age from Nature Chemistry
of 66 outputs
Altmetric has tracked 24,588,574 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,233 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.4. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,772 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.