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Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia

Overview of attention for article published in Nature Chemistry, January 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

news
4 news outlets
twitter
16 tweeters

Citations

dimensions_citation
37 Dimensions

Readers on

mendeley
52 Mendeley
Title
Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia
Published in
Nature Chemistry, January 2016
DOI 10.1038/nchem.2384
Pubmed ID
Authors

Hongyu Li, Hennie Valkenier, Luke W. Judd, Peter R. Brotherhood, Sabir Hussain, James A. Cooper, Ondřej Jurček, Hazel A. Sparkes, David N. Sheppard, Anthony P. Davis

Abstract

Transmembrane anion transporters (anionophores) have potential for new modes of biological activity, including therapeutic applications. In particular they might replace the activity of defective anion channels in conditions such as cystic fibrosis. However, data on the biological effects of anionophores are scarce, and it remains uncertain whether such molecules are fundamentally toxic. Here, we report a biological study of an extensive series of powerful anion carriers. Fifteen anionophores were assayed in single cells by monitoring anion transport in real time through fluorescence emission from halide-sensitive yellow fluorescent protein. A bis-(p-nitrophenyl)ureidodecalin shows especially promising activity, including deliverability, potency and persistence. Electrophysiological tests show strong effects in epithelia, close to those of natural anion channels. Toxicity assays yield negative results in three cell lines, suggesting that promotion of anion transport may not be deleterious to cells. We therefore conclude that synthetic anion carriers are realistic candidates for further investigation as treatments for cystic fibrosis.

Twitter Demographics

The data shown below were collected from the profiles of 16 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Portugal 1 2%
Mexico 1 2%
Unknown 49 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 31%
Student > Master 10 19%
Student > Bachelor 10 19%
Researcher 4 8%
Unspecified 3 6%
Other 9 17%
Readers by discipline Count As %
Chemistry 33 63%
Agricultural and Biological Sciences 7 13%
Unspecified 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Medicine and Dentistry 2 4%
Other 3 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2016.
All research outputs
#331,691
of 11,756,696 outputs
Outputs from Nature Chemistry
#378
of 2,011 outputs
Outputs of similar age
#12,204
of 250,893 outputs
Outputs of similar age from Nature Chemistry
#14
of 66 outputs
Altmetric has tracked 11,756,696 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,011 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.8. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,893 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.