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Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia

Overview of attention for article published in Nature Chemistry, November 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

news
4 news outlets
twitter
17 tweeters

Readers on

mendeley
45 Mendeley
Title
Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia
Published in
Nature Chemistry, November 2015
DOI 10.1038/nchem.2384
Pubmed ID
Authors

Hongyu Li, Hennie Valkenier, Luke W. Judd, Peter R. Brotherhood, Sabir Hussain, James A. Cooper, Ondřej Jurček, Hazel A. Sparkes, David N. Sheppard, Anthony P. Davis

Abstract

Transmembrane anion transporters (anionophores) have potential for new modes of biological activity, including therapeutic applications. In particular they might replace the activity of defective anion channels in conditions such as cystic fibrosis. However, data on the biological effects of anionophores are scarce, and it remains uncertain whether such molecules are fundamentally toxic. Here, we report a biological study of an extensive series of powerful anion carriers. Fifteen anionophores were assayed in single cells by monitoring anion transport in real time through fluorescence emission from halide-sensitive yellow fluorescent protein. A bis-(p-nitrophenyl)ureidodecalin shows especially promising activity, including deliverability, potency and persistence. Electrophysiological tests show strong effects in epithelia, close to those of natural anion channels. Toxicity assays yield negative results in three cell lines, suggesting that promotion of anion transport may not be deleterious to cells. We therefore conclude that synthetic anion carriers are realistic candidates for further investigation as treatments for cystic fibrosis.

Twitter Demographics

The data shown below were collected from the profiles of 17 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Portugal 1 2%
United Kingdom 1 2%
Mexico 1 2%
Unknown 41 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 31%
Student > Master 9 20%
Student > Bachelor 5 11%
Researcher 4 9%
Student > Doctoral Student 3 7%
Other 4 9%
Unknown 6 13%
Readers by discipline Count As %
Chemistry 31 69%
Agricultural and Biological Sciences 3 7%
Chemical Engineering 1 2%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Unspecified 1 2%
Other 2 4%
Unknown 6 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2016.
All research outputs
#213,785
of 8,091,793 outputs
Outputs from Nature Chemistry
#291
of 1,707 outputs
Outputs of similar age
#11,202
of 244,057 outputs
Outputs of similar age from Nature Chemistry
#14
of 66 outputs
Altmetric has tracked 8,091,793 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,707 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.3. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,057 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.