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Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia

Overview of attention for article published in Nature Chemistry, November 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

news
4 news outlets
twitter
13 tweeters

Citations

dimensions_citation
106 Dimensions

Readers on

mendeley
97 Mendeley
Title
Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia
Published in
Nature Chemistry, November 2015
DOI 10.1038/nchem.2384
Pubmed ID
Authors

Hongyu Li, Hennie Valkenier, Luke W. Judd, Peter R. Brotherhood, Sabir Hussain, James A. Cooper, Ondřej Jurček, Hazel A. Sparkes, David N. Sheppard, Anthony P. Davis

Abstract

Transmembrane anion transporters (anionophores) have potential for new modes of biological activity, including therapeutic applications. In particular they might replace the activity of defective anion channels in conditions such as cystic fibrosis. However, data on the biological effects of anionophores are scarce, and it remains uncertain whether such molecules are fundamentally toxic. Here, we report a biological study of an extensive series of powerful anion carriers. Fifteen anionophores were assayed in single cells by monitoring anion transport in real time through fluorescence emission from halide-sensitive yellow fluorescent protein. A bis-(p-nitrophenyl)ureidodecalin shows especially promising activity, including deliverability, potency and persistence. Electrophysiological tests show strong effects in epithelia, close to those of natural anion channels. Toxicity assays yield negative results in three cell lines, suggesting that promotion of anion transport may not be deleterious to cells. We therefore conclude that synthetic anion carriers are realistic candidates for further investigation as treatments for cystic fibrosis.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Portugal 1 1%
Unknown 95 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 34%
Student > Master 18 19%
Student > Bachelor 15 15%
Researcher 8 8%
Professor > Associate Professor 6 6%
Other 8 8%
Unknown 9 9%
Readers by discipline Count As %
Chemistry 56 58%
Agricultural and Biological Sciences 9 9%
Biochemistry, Genetics and Molecular Biology 9 9%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Medicine and Dentistry 5 5%
Other 3 3%
Unknown 10 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 38. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2016.
All research outputs
#727,340
of 19,046,601 outputs
Outputs from Nature Chemistry
#670
of 2,705 outputs
Outputs of similar age
#15,403
of 296,571 outputs
Outputs of similar age from Nature Chemistry
#11
of 57 outputs
Altmetric has tracked 19,046,601 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,705 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.4. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,571 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.