| Title |
Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques
|
|---|---|
| Published in |
Nature Communications, August 2018
|
| DOI | 10.1038/s41467-018-05826-w |
| Pubmed ID | |
| Authors |
Megan A. O’Connor, Jennifer Tisoncik-Go, Thomas B. Lewis, Charlene J. Miller, Debra Bratt, Cassie R. Moats, Paul T. Edlefsen, Jeremy Smedley, Nichole R. Klatt, Michael Gale, Deborah Heydenburg Fuller |
| Abstract |
The immunological and virological events that contribute to the establishment of Zika virus (ZIKV) infection in humans are unclear. Here, we show that robust cellular innate immune responses arising early in the blood and tissues in response to ZIKV infection are significantly stronger in males and correlate with increased viral persistence. In particular, early peripheral blood recruitment of plasmacytoid dendritic cells and higher production of monocyte chemoattractant protein (MCP-1) correspond with greater viral persistence and tissue dissemination. We also identify non-classical monocytes as primary in vivo targets of ZIKV infection in the blood and peripheral lymph node. These results demonstrate the potential differences in ZIKV pathogenesis between males and females and a key role for early cellular innate immune responses in the blood in viral dissemination and ZIKV pathogenesis. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 20% |
| Mexico | 1 | 7% |
| United Kingdom | 1 | 7% |
| Switzerland | 1 | 7% |
| Australia | 1 | 7% |
| Unknown | 8 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 60% |
| Science communicators (journalists, bloggers, editors) | 4 | 27% |
| Scientists | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 72 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 24% |
| Student > Master | 12 | 17% |
| Student > Ph. D. Student | 10 | 14% |
| Student > Bachelor | 9 | 13% |
| Student > Doctoral Student | 5 | 7% |
| Other | 8 | 11% |
| Unknown | 11 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 17 | 24% |
| Agricultural and Biological Sciences | 12 | 17% |
| Biochemistry, Genetics and Molecular Biology | 10 | 14% |
| Medicine and Dentistry | 6 | 8% |
| Arts and Humanities | 3 | 4% |
| Other | 9 | 13% |
| Unknown | 15 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2022.
All research outputs
#4,004,086
of 24,450,293 outputs
Outputs from Nature Communications
#33,212
of 52,461 outputs
Outputs of similar age
#73,541
of 337,859 outputs
Outputs of similar age from Nature Communications
#896
of 1,385 outputs
Altmetric has tracked 24,450,293 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 52,461 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,859 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 1,385 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.