RT @doctorveera: 2. Polygenic tail vs Monogenic cases. We all might remember this popular paper that made an argument for the first time t…
RT @doctorveera: 2. Polygenic tail vs Monogenic cases. We all might remember this popular paper that made an argument for the first time t…
2. Polygenic tail vs Monogenic cases. We all might remember this popular paper that made an argument for the first time that individuals at the extreme end of PRS distribution have similar disease risks as monogenic cases. https://t.co/QoJlGM5i4K https:
@Divorytaur Goeie vraag! Klopt, dat is inderdaad onze definitie van associatie. De DNA locatie is gecorreleerd aan een ziekte. Het bijzondere is dat je deze locaties ook kunt gebruiken om ziekterisico te voorspellen. Zoals in dit paper te lezen is. https
@economistrent Why don't you try making accurate statements and accept geneticists read the literature too. eg. the concept is common knowledge https://t.co/VJQDs9gXiB
RT @jacobjchr: And finally a fairly recent classic: Genome-wide polygenic scores for common diseases identify individuals with risk equival…
@lpachter @james_t_webber The "discovery" is the results of this paper and subsequent. They discovered that an approach to combining statistical information, applied to the right data, can generate usable results. https://t.co/I5jjnUlzx3
@dr_appie This seems very premature, yes. But do we need to understand biology, when afawk the high-scorers for some of these diseases (e.g. CAD) are at higher risk than ind. carrying monogenic mutations/variants. https://t.co/3k8CedfKNm We already test/as
@DocEdge85 @AlexTISYoung @mathiesoniain Coronary Artery Disease seems like a good trait example of the later at this point, e.g. https://t.co/dspEFedUaa
And finally a fairly recent classic: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations https://t.co/wDtY5306TJ @NatureGenet
Another notable finding here is the individuals at the tail of the PRS distribution(>90th percentile) has similar risk as individuals with a monogenic cause (in this case CHEK2 mutation). This concept was first demonstrated in this landmark paper: https
RT @redGDPS: El código genético …. rs1333458 Clinical utilities of this knowledge: ✅Cardiovascular risk estimation/Prognosis. Plom…
RT @redGDPS: El código genético …. rs1333458 Clinical utilities of this knowledge: ✅Cardiovascular risk estimation/Prognosis. Plom…
RT @redGDPS: El código genético …. rs1333458 Clinical utilities of this knowledge: ✅Cardiovascular risk estimation/Prognosis. Plom…
RT @redGDPS: El código genético …. rs1333458 Clinical utilities of this knowledge: ✅Cardiovascular risk estimation/Prognosis. Plom…
RT @redGDPS: El código genético …. rs1333458 Clinical utilities of this knowledge: ✅Cardiovascular risk estimation/Prognosis. Plom…
RT @redGDPS: El código genético …. rs1333458 Clinical utilities of this knowledge: ✅Cardiovascular risk estimation/Prognosis. Plom…
RT @redGDPS: El código genético …. rs1333458 Clinical utilities of this knowledge: ✅Cardiovascular risk estimation/Prognosis. Plom…
RT @redGDPS: El código genético …. rs1333458 Clinical utilities of this knowledge: ✅Cardiovascular risk estimation/Prognosis. Plom…
El código genético …. rs1333458 Clinical utilities of this knowledge: ✅Cardiovascular risk estimation/Prognosis. Plomin et al. Nat. Rev. Gen. 2009 https://t.co/0CLAZcIll5 Khera AV et al. Nat Genet. 2018;50:1219-1224 https://t.co/0j9jXn06CD https
@cecilejanssens At a high PRS score, the risk can be 3x-5x the average. This has been validated by multiple research groups, e.g., https://t.co/A889LxKH3Y In other words, as the title of the above paper says, PRS identifies risk equivalent to monogenic mut
When combined as a PRS the SNPs may start to have some impact, e.g. @amitvkhera (https://t.co/sKTXVmkQyc) and @flowuenne (https://t.co/XBexOBLNqs) and many others. The magnitude may be up for discussion (@cecilejanssens), but it’s definitely better than i
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations #InWhites https://t.co/i06rjiEMcw
RT @VerveTx: Genetics can play a role in a person's risk of developing coronary artery disease. Using polygenic risk scores scientists can…
Hypothesis: A genome wide polygenic risk score for coronary artery disease (developed here: https://t.co/jyP78aqwtK) will predict risk of MI among patients with high Lp(a). To test, we examined effect of CAD PRS on risk of MI in patients with/without hig
RT @VerveTx: Genetics can play a role in a person's risk of developing coronary artery disease. Using polygenic risk scores scientists can…
Genetics can play a role in a person's risk of developing coronary artery disease. Using polygenic risk scores scientists can calculate a person’s overall risk of developing a disease based on variations in their genes. Learn more: https://t.co/PWiX7lIpkI
In this paper (https://t.co/o4YTKqyBqr), PRS predicted CAD...but beyond what's been raised about the validity of prediction, what exactly is being predicted? Compare the beautiful prediction pic for 'CAD' with how CAD was defined. Clinically meaningful?cc
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
RT @EricTopol: Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar ri…
Another important role for polygenic risk scores. Previously Amit, Sek and their team showed us how very hi PRS = similar risk as monogenic diseases (like FH, BRCA): https://t.co/eRisYjpUtB Now their role like "modifiers" of penetrance for monogenic diseas
RT @skathire: #replication_in_science_is_satisfying @amitvkhera's plot of CAD prevalence by genome-wide polygenic score in @uk_biobank fro…
RT @skathire: #replication_in_science_is_satisfying @amitvkhera's plot of CAD prevalence by genome-wide polygenic score in @uk_biobank fro…
RT @skathire: #replication_in_science_is_satisfying @amitvkhera's plot of CAD prevalence by genome-wide polygenic score in @uk_biobank fro…
RT @skathire: #replication_in_science_is_satisfying @amitvkhera's plot of CAD prevalence by genome-wide polygenic score in @uk_biobank fro…
#replication_in_science_is_satisfying @amitvkhera's plot of CAD prevalence by genome-wide polygenic score in @uk_biobank from last year (L) Damask's plot of same in @GeisingerHealth from publication today (R) https://t.co/bEoCfzcnRg https://t.co/gPPSEz
RT @skathire: "the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome…
RT @metapredict: Yikes! “Although the AUC in the full model is high in both ancestries (0.57-0.84), showing ability to distinguish between…
Yikes! “Although the AUC in the full model is high in both ancestries (0.57-0.84), showing ability to distinguish between cases and controls” T2DM AUC was <0.6 AUC. Do they know ~0.5 is random I wonder... big cohort, small p-values but translatable?
RT @skathire: "the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome…
RT @skathire: "the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome…
RT @skathire: "the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome…
RT @skathire: "the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome…
RT @skathire: "the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome…
"the PRS with the largest effect size was myocardial infarction, followed by coronary artery disease." music to my👂🏽 genome-wide PRS in a new biobank, independent of our or @minouye271 original reports https://t.co/bEoCfzcnRg https://t.co/bydETs45ZP
RT @NHLBI_Translate: We agree. It is also time to explore strategies to accelerate their rapid adoption and sustained use in appropriate c…
2) larger polygenic scores made up of millions of SNPs have been developed for lipids (https://t.co/9QDPHXlHG7) and CAD (https://t.co/jyP78aqwtK). These merit assessment in FH.
@amitvkhera where can we find distributions mapping raw polygenic scores (for coronary artery disease, etc.) to percentiles reported in https://t.co/403hOkqNL6?
@C_Glastonbury @flowuenne @GLettre @ArsenaultBenoit @amitvkhera As you likely know, our original observation was not a GWAS but a specific approach to combining variants across the genome to interpret risk https://t.co/bEoCfzcnRg
@michelnivard @JimvanOs1 Thanks for the interest. Btw, article is free here: https://t.co/JEM5fcuRYZ Regarding the Qs; 1-In brief, why not? (though much about this can be discussed for PRS and also the exposures). Related https://t.co/7HHNwl4noB https://t.
super cool example of polygenic risk scoring being clinically useful
In Khera et al @skathire used data from the @uk_biobank and found that high polygenic risk score individuals had increased risk for heart attacks https://t.co/3b27JKQm7t https://t.co/J9uxdkdGex (includes patents 😮) #BoG19 https://t.co/9qGk0mHLEu
Fascinating work by @amitvkhera and his collaborators on the public health impact of polygenic risk scores across the lifespan! #GMXII https://t.co/V6ZzoFagHO & https://t.co/NAVJ3I47bN https://t.co/zkB3AsSNV4
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. https://t.co/812K5pMLKv
RT @MRC_Epid: Exciting to share the pages of this @CellCellPress issue with @amitvkhera @skathire! Great and thought provoking work on pol…
Exciting to share the pages of this @CellCellPress issue with @amitvkhera @skathire! Great and thought provoking work on polygenic risk scores https://t.co/0O1GBlAvKu https://t.co/CdmVgec70v https://t.co/9ligSkDWgD #genetics #obesity #weightloss #GPCR #
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @JLojim: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations | Nature Gene…
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations | Nature Genetics Time to contemplate the inclusion of polygenic risk prediction in clinical care? https://t.co/EfVa6A8Dt6
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…
RT @EricTopol: Over the course of a lifetime, 12% of women have a risk of breast #cancer. But guidelines recommend screening 100% (w/ 60% f…