RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
Not only did @amitvkhera and colleagues make one of the top research advances of the year, they also shared their results in the Cardiovascular Disease Knowledge Portal! https://t.co/G4y5Xlnt3R
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
RT @amitvkhera: Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — n…
Thank you, @AHA_Research, for highlighting our work on genome-wide polygenic scores as a top research advance of 2018 — now on to optimizing approach, disclosure, and demonstrating clinical utility. https://t.co/Ptbe6zLZuY https://t.co/ZzHbdVDkBs cc:
In Sek's paper https://t.co/dDtANyXQDS the AUC for IBD is 0.63 (Table 1), but the odds ratio for the top 0.5% is 4.81. If the number of patients at high risk is low, diagnosing them correctly will not significantly improve the AUC, but is still relevant fo
@Apestatic @TimRooney10 @jorio1984 @nntaleb @rjhaier Stuart Ritchie, the IQ researcher, named the Lee et al. (2018) GWAS as one of his favourite papers of 2018. https://t.co/SsDt587yI0
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT briandavidearp: RT StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/qdCkLpUk7q), genetic nurture (https://t.co/mgWWtlpYV3), & genetic prediction of coronary artery disease (https://t.co/P2w5znr1
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
RT @StuartJRitchie: What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (h…
What are your favourite scientific papers of 2018? Mine are probably: EA3 (https://t.co/DpEmglQsSm), genetic nurture (https://t.co/NPWdKqZrs1), & genetic prediction of coronary artery disease (https://t.co/Q893FJwh9c) - it's been a pretty polygenic yea
@DrMJoyner @KenWeiss1 @leonidkruglyak @markmccarthyoxf @cecilejanssens From 2000 Paper: "enthusiasm is based on the hope that...common alleles account for a substantial proportion of the population risk...in a usefully predictive way." Well, hope no more.
@davecurtis314 @michelnivard Thanks Dave & Michel, v interesting. What do you think about this? https://t.co/gJvxljAsYl https://t.co/0plpb4Wrij
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
thanks @skathire for visiting @UChicagoMed today and discussing your group's many approaches to the genetic basis for MI, including recent work on polygenic risk score for common diseases (link). Looking forward to #AHA18. https://t.co/0z5iFspCmK @amitv
RT @Brooke_LaFlamme: Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18…
RT @Brooke_LaFlamme: Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18…
@MaartenvSmeden @f2harrell @venkmurthy @ADAlthousePhD I may be way too pragmatic for a serious discussion on this. For the 6M covariate question (https://t.co/xqHufr4Qz5), I would start with rounding coefficients to 3 decimals and drop all that are zero :-
Her er lenke til originalartikkelen fra Khera og medarbeidere i @NatureGenet, som jeg omtaler i dagens @Morgenbladet: https://t.co/EzGt6dFMpm
RT @yluo86: .@skathire presents their brilliant work published in @NatureGenet on genome-wide polygenic scores for common diseases identif…
RT @Brooke_LaFlamme: Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18…
RT @Brooke_LaFlamme: Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18…
RT @Brooke_LaFlamme: Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18…
RT @Brooke_LaFlamme: Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18…
RT @Brooke_LaFlamme: Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18…
RT @yluo86: .@skathire presents their brilliant work published in @NatureGenet on genome-wide polygenic scores for common diseases identif…
RT @yluo86: .@skathire presents their brilliant work published in @NatureGenet on genome-wide polygenic scores for common diseases identif…
RT @yluo86: .@skathire presents their brilliant work published in @NatureGenet on genome-wide polygenic scores for common diseases identif…
RT @yluo86: .@skathire presents their brilliant work published in @NatureGenet on genome-wide polygenic scores for common diseases identif…
.@skathire presents their brilliant work published in @NatureGenet on genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations #ashg18 https://t.co/5Whi7Fv2XP
SK cites recent paper Khera et al 2018 https://t.co/n7tQAZdMmM #ashg18
A great resource! So much of my thinking about risk for serious mental illness has come from reading about assessment and management of risk for CV disease.
RT @Brooke_LaFlamme: Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18…
RT @Brooke_LaFlamme: Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18…
RT @Brooke_LaFlamme: Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18…
RT @Brooke_LaFlamme: Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18…
RT @Brooke_LaFlamme: Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18…
RT @Brooke_LaFlamme: Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18…
Free to read version of @skathire’s recent paper in @NatureGenet on polygenic risk scores for common diseases #ASHG18 https://t.co/bHYTTQ2cM4 #SharedIt https://t.co/8di5JswwL9
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations https://t.co/1oCYaJgugB
Polygenic risk scores represent a giant leap for gene-based diagnostic tests. Read more here: https://t.co/ZczZLAu72n
RT @PoojaJha2015: Polygenic risk scores are becoming as good a disease predictor as monogenic #mutations. A very interesting study publishe…
Polygenic risk scores are becoming as good a disease predictor as monogenic #mutations. A very interesting study published by Sekar Kathiresan's group @skathire has created a big splash and hope for personalised medicine.@NatureGenet https://t.co/hcdJfjJwV
RT @piparina890: #StEmlynsLIVE @richardbody Highlighting to the audience the topic of POLYGENIC Risk Scoring for patients presenting with…
RT @adamhulman: "practising clinicians could not identify the 8% of individuals at ≥3-fold risk based on genome-wide polygenic score for CA…
"practising clinicians could not identify the 8% of individuals at ≥3-fold risk based on genome-wide polygenic score for CAD using conventional risk factors" Why would they even try to find those at high genetic risk instead of those at high overall risk?
RT @piparina890: #StEmlynsLIVE @richardbody Highlighting to the audience the topic of POLYGENIC Risk Scoring for patients presenting with…
RT @piparina890: #StEmlynsLIVE @richardbody Highlighting to the audience the topic of POLYGENIC Risk Scoring for patients presenting with…
#StEmlynsLIVE @richardbody Highlighting to the audience the topic of POLYGENIC Risk Scoring for patients presenting with ? ACS Interesting reading! https://t.co/sdIo01UHgF
RT @ttle161803: Excited for today Lunch&Learn! @JEMgenes and I will be leading the discussion on the PRS review paper by @ATorkamani et al.…
RT @ttle161803: Excited for today Lunch&Learn! @JEMgenes and I will be leading the discussion on the PRS review paper by @ATorkamani et al.…
RT @ttle161803: Excited for today Lunch&Learn! @JEMgenes and I will be leading the discussion on the PRS review paper by @ATorkamani et al.…
Excited for today Lunch&Learn! @JEMgenes and I will be leading the discussion on the PRS review paper by @ATorkamani et al. https://t.co/MF69nGxoAw followed by @skathire group's work on utilizing genome-wide PRS. https://t.co/w67zp4VmZ3 Slides: http
When you read a new polygenic risk score study but you are more interested in @cecilejanssens take on it. https://t.co/xYsCRzLByE
The polygenic score has become a promising approach with applications ranging from bioengineering to precision medicine. Although its use in the clinic is yet a little far, a letter in Nature Genetics shows its potentiel in identifying high-risk patients.
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
RT @skathire: What is inherited basis for heart attack? A new quantitative (genome-wide polygenic score) that captures inherited liability…
@CardioMaths - this is the future of risk prediction and patient stratification https://t.co/CgbiNHYqIG
RT @MetaHICN: #Genome-wide polygenic scores can identify individuals at high or low risk for CAD, AFib, T2D, IBD, and breast cancer https:…
#Genome-wide polygenic scores can identify individuals at high or low risk for CAD, AFib, T2D, IBD, and breast cancer https://t.co/cN9JpRcVU1 https://t.co/E98fHueI1k
RT @drdargaray: Un nuevo ensayo genético que detecta la susceptibilidad individual para un ataque cardiaco. Cual será el papel del cribado…
RT @NatureGenet: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (Khera e…
Kathiresan #AGBTph18 Polygenic risk scores, '16 ref https://t.co/5twWIAUb73 '18 ref https://t.co/qUsqHwIo0T Polyenic score can ID risk = monogenic mut
Genetic risk scores nearing the clinic? https://t.co/lduTGayMiN
RT @broadinstitute: .@amitvkhera explains how polygenic risk scores are developed. You can read Khera's recent publication in @NatureGenet…
From this v interesting paper about predicting risk of common illnesses by combining loads of genetic variants into a combined risk score... https://t.co/omMJ08nmkg
RT @NatureGenet: #NatGenNV Genetic risks and clinical rewards (Schork, Schork & Schork) https://t.co/Yu2j4ED6hZ on Khera et al. https://t.c…
#LI #Genome-wide #polygenic scores for common #diseases identify individuals with risk equivalent to #monogenic #mutations @NatureGenet https://t.co/j1G8Vv7Tut
FYI: Article referred to in this story is https://t.co/6HsaGPLJZo https://t.co/qGLMMEDwiI
RT @NatureGenet: #NatGenNV Genetic risks and clinical rewards (Schork, Schork & Schork) https://t.co/Yu2j4ED6hZ on Khera et al. https://t.c…
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations @NatureGenet https://t.co/CMNBZiCRZN
RT @NatureGenet: #NatGenNV Genetic risks and clinical rewards (Schork, Schork & Schork) https://t.co/Yu2j4ED6hZ on Khera et al. https://t.c…
Des profils polygéniques peuvent s'associer à des risques très supérieurs à une seule #mutation : 20 fois plus pour la #maladiecoronaire par exemple 😶 https://t.co/kDyxyYGn1J
RT @markmccarthyoxf: Excellent - and to my mind fair - summary of the potential of grs for patient care, and the obstacles that need to be…
RT @NatureGenet: #NatGenNV Genetic risks and clinical rewards (Schork, Schork & Schork) https://t.co/Yu2j4ED6hZ on Khera et al. https://t.c…
RT @NatureGenet: #NatGenNV Genetic risks and clinical rewards (Schork, Schork & Schork) https://t.co/Yu2j4ED6hZ on Khera et al. https://t.c…
RT @NatureGenet: #NatGenNV Genetic risks and clinical rewards (Schork, Schork & Schork) https://t.co/Yu2j4ED6hZ on Khera et al. https://t.c…