| Title |
Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents
|
|---|---|
| Published in |
Scientific Reports, September 2015
|
| DOI | 10.1038/srep14046 |
| Pubmed ID | |
| Authors |
Ao Guo, Dongming He, Hong-Bo Xu, Chang-An Geng, Jian Zhao |
| Abstract |
Regulatory T cells (Treg) play a critical role to control immune responses and to prevent autoimmunity, thus selective increase of Treg cells in vivo has broad therapeutic implications for autoimmune and inflammatory diseases. Licorice is a well-known herbal medicine used worldwide for over thousands of years, and accumulating evidence has shown its immunomodulatory potential. However, it is not clear whether licorice could regulate the induction and function of Treg cells. Here we found licorice extract could promote Treg cell induction, and then we used a rational approach to isolate its functional fractions and constituents. The results showed that two constituents, isoliquiritigenin and naringenin, promoted Treg cell induction both in vitro and in vivo. The effective fractions and two constituents of licorice also enhanced immune suppression of Treg cells, and they further reduced severity of DSS-induced colitis in mice. This study suggested that promotion of regulatory T cell induction could be an underlying mechanism of the historically and widely used herbal medicine licorice, providing its two effective molecules against autoimmune and inflammatory diseases. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| Poland | 1 | 1% |
| Unknown | 71 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 13% |
| Student > Master | 10 | 13% |
| Student > Bachelor | 7 | 9% |
| Student > Ph. D. Student | 6 | 8% |
| Other | 5 | 7% |
| Other | 18 | 24% |
| Unknown | 19 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 12% |
| Immunology and Microbiology | 9 | 12% |
| Agricultural and Biological Sciences | 4 | 5% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Other | 9 | 12% |
| Unknown | 26 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2017.
All research outputs
#1,874,881
of 23,577,654 outputs
Outputs from Scientific Reports
#17,150
of 127,511 outputs
Outputs of similar age
#26,608
of 270,223 outputs
Outputs of similar age from Scientific Reports
#293
of 2,139 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 127,511 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.4. This one has done well, scoring higher than 86% of its peers.
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We're also able to compare this research output to 2,139 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.