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Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents

Overview of attention for article published in Scientific Reports, September 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

news
1 news outlet
twitter
3 tweeters
patent
1 patent
facebook
1 Facebook page

Citations

dimensions_citation
35 Dimensions

Readers on

mendeley
50 Mendeley
Title
Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents
Published in
Scientific Reports, September 2015
DOI 10.1038/srep14046
Pubmed ID
Authors

Ao Guo, Dongming He, Hong-Bo Xu, Chang-An Geng, Jian Zhao

Abstract

Regulatory T cells (Treg) play a critical role to control immune responses and to prevent autoimmunity, thus selective increase of Treg cells in vivo has broad therapeutic implications for autoimmune and inflammatory diseases. Licorice is a well-known herbal medicine used worldwide for over thousands of years, and accumulating evidence has shown its immunomodulatory potential. However, it is not clear whether licorice could regulate the induction and function of Treg cells. Here we found licorice extract could promote Treg cell induction, and then we used a rational approach to isolate its functional fractions and constituents. The results showed that two constituents, isoliquiritigenin and naringenin, promoted Treg cell induction both in vitro and in vivo. The effective fractions and two constituents of licorice also enhanced immune suppression of Treg cells, and they further reduced severity of DSS-induced colitis in mice. This study suggested that promotion of regulatory T cell induction could be an underlying mechanism of the historically and widely used herbal medicine licorice, providing its two effective molecules against autoimmune and inflammatory diseases.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 6%
Poland 1 2%
Unknown 46 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 18%
Student > Bachelor 7 14%
Student > Master 6 12%
Other 5 10%
Student > Doctoral Student 3 6%
Other 11 22%
Unknown 9 18%
Readers by discipline Count As %
Medicine and Dentistry 11 22%
Pharmacology, Toxicology and Pharmaceutical Science 6 12%
Immunology and Microbiology 5 10%
Agricultural and Biological Sciences 4 8%
Biochemistry, Genetics and Molecular Biology 4 8%
Other 5 10%
Unknown 15 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2017.
All research outputs
#743,955
of 12,149,975 outputs
Outputs from Scientific Reports
#6,938
of 54,320 outputs
Outputs of similar age
#22,089
of 241,109 outputs
Outputs of similar age from Scientific Reports
#265
of 2,000 outputs
Altmetric has tracked 12,149,975 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 54,320 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,109 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 2,000 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.