| Title |
Kinase-controlled phase transition of membraneless organelles in mitosis
|
|---|---|
| Published in |
Nature, July 2018
|
| DOI | 10.1038/s41586-018-0279-8 |
| Pubmed ID | |
| Authors |
Arpan Kumar Rai, Jia-Xuan Chen, Matthias Selbach, Lucas Pelkmans |
| Abstract |
Liquid-liquid phase separation has been shown to underlie the formation and disassembly of membraneless organelles in cells, but the cellular mechanisms that control this phenomenon are poorly understood. A prominent example of regulated and reversible segregation of liquid phases may occur during mitosis, when membraneless organelles disappear upon nuclear-envelope breakdown and reappear as mitosis is completed. Here we show that the dual-specificity kinase DYRK3 acts as a central dissolvase of several types of membraneless organelle during mitosis. DYRK3 kinase activity is essential to prevent the unmixing of the mitotic cytoplasm into aberrant liquid-like hybrid organelles and the over-nucleation of spindle bodies. Our work supports a mechanism in which the dilution of phase-separating proteins during nuclear-envelope breakdown and the DYRK3-dependent degree of their solubility combine to allow cells to dissolve and condense several membraneless organelles during mitosis. |
X Demographics
The data shown below were collected from the profiles of 95 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 20 | 21% |
| United Kingdom | 10 | 11% |
| Japan | 8 | 8% |
| Germany | 5 | 5% |
| Canada | 4 | 4% |
| Spain | 4 | 4% |
| Switzerland | 2 | 2% |
| Italy | 1 | 1% |
| France | 1 | 1% |
| Other | 9 | 9% |
| Unknown | 31 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 45 | 47% |
| Members of the public | 45 | 47% |
| Science communicators (journalists, bloggers, editors) | 4 | 4% |
| Practitioners (doctors, other healthcare professionals) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 553 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 553 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 120 | 22% |
| Researcher | 100 | 18% |
| Student > Master | 54 | 10% |
| Student > Bachelor | 50 | 9% |
| Professor | 29 | 5% |
| Other | 90 | 16% |
| Unknown | 110 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 232 | 42% |
| Agricultural and Biological Sciences | 95 | 17% |
| Chemistry | 30 | 5% |
| Physics and Astronomy | 13 | 2% |
| Neuroscience | 13 | 2% |
| Other | 54 | 10% |
| Unknown | 116 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 112. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2021.
All research outputs
#372,822
of 25,378,162 outputs
Outputs from Nature
#18,923
of 97,719 outputs
Outputs of similar age
#8,141
of 342,719 outputs
Outputs of similar age from Nature
#398
of 926 outputs
Altmetric has tracked 25,378,162 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 97,719 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.4. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,719 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 926 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.