| Title |
Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin
|
|---|---|
| Published in |
Scientific Reports, July 2015
|
| DOI | 10.1038/srep12012 |
| Pubmed ID | |
| Authors |
Zhuoran Wang, Lu Zhang, Yaru Liang, Chi Zhang, Zhiyu Xu, Lang Zhang, Ryosuke Fuji, Wei Mu, Liyuan Li, Junjun Jiang, Yong Ju, Zhao Wang |
| Abstract |
Cyclic adenosine monophosphate (cAMP) plays an important role in many biological processes as a second messenger, and cAMP treatment has been reported to extend the lifespan of wild-type Drosophila melanogaster. Our study showed that exogenous cAMP improved ageing-related phenotypes by increasing the protein level of Sirtuins, which prevented metabolic disorders to mimic the effect of calorie restriction. Experiments in vitro showed that cAMP directly bound to SIRT1 and SIRT3 and consequently increased their activity. These findings suggest that cAMP slows the ageing process and is a good candidate to mimic calorie restriction. Our research provides a promising therapeutic strategy to target metabolic disorder-induced ageing-related diseases. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 30% |
| Germany | 1 | 10% |
| Austria | 1 | 10% |
| Unknown | 5 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 40% |
| Members of the public | 3 | 30% |
| Practitioners (doctors, other healthcare professionals) | 2 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | 1% |
| United States | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 72 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 24% |
| Researcher | 14 | 19% |
| Student > Bachelor | 10 | 13% |
| Student > Master | 10 | 13% |
| Lecturer | 3 | 4% |
| Other | 7 | 9% |
| Unknown | 13 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 24% |
| Biochemistry, Genetics and Molecular Biology | 16 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
| Medicine and Dentistry | 5 | 7% |
| Chemistry | 3 | 4% |
| Other | 8 | 11% |
| Unknown | 20 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2020.
All research outputs
#6,601,449
of 24,072,790 outputs
Outputs from Scientific Reports
#44,655
of 130,818 outputs
Outputs of similar age
#72,579
of 266,306 outputs
Outputs of similar age from Scientific Reports
#644
of 2,034 outputs
Altmetric has tracked 24,072,790 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 130,818 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.6. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,306 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 2,034 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.