| Title |
Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients
|
|---|---|
| Published in |
Nature Communications, July 2015
|
| DOI | 10.1038/ncomms8686 |
| Pubmed ID | |
| Authors |
Mark Sausen, Jillian Phallen, Vilmos Adleff, Siân Jones, Rebecca J. Leary, Michael T. Barrett, Valsamo Anagnostou, Sonya Parpart-Li, Derek Murphy, Qing Kay Li, Carolyn A. Hruban, Rob Scharpf, James R. White, Peter J. O’Dwyer, Peter J. Allen, James R. Eshleman, Craig B. Thompson, David S. Klimstra, David C. Linehan, Anirban Maitra, Ralph H. Hruban, Luis A. Diaz, Daniel D. Von Hoff, Julia S. Johansen, Jeffrey A. Drebin, Victor E. Velculescu |
| Abstract |
Pancreatic adenocarcinoma has the worst mortality of any solid cancer. In this study, to evaluate the clinical implications of genomic alterations in this tumour type, we perform whole-exome analyses of 24 tumours, targeted genomic analyses of 77 tumours, and use non-invasive approaches to examine tumour-specific mutations in the circulation of these patients. These analyses reveal somatic mutations in chromatin-regulating genes MLL, MLL2, MLL3 and ARID1A in 20% of patients that are associated with improved survival. We observe alterations in genes with potential therapeutic utility in over a third of cases. Liquid biopsy analyses demonstrate that 43% of patients with localized disease have detectable circulating tumour DNA (ctDNA) at diagnosis. Detection of ctDNA after resection predicts clinical relapse and poor outcome, with recurrence by ctDNA detected 6.5 months earlier than with CT imaging. These observations provide genetic predictors of outcome in pancreatic cancer and have implications for new avenues of therapeutic intervention. |
X Demographics
The data shown below were collected from the profiles of 38 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 16 | 42% |
| Greece | 1 | 3% |
| Germany | 1 | 3% |
| Japan | 1 | 3% |
| Korea, Republic of | 1 | 3% |
| United Kingdom | 1 | 3% |
| China | 1 | 3% |
| Spain | 1 | 3% |
| Belgium | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 14 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 47% |
| Scientists | 15 | 39% |
| Practitioners (doctors, other healthcare professionals) | 4 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 372 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 1% |
| France | 1 | <1% |
| Ireland | 1 | <1% |
| South Africa | 1 | <1% |
| Sweden | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 362 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 72 | 19% |
| Student > Ph. D. Student | 64 | 17% |
| Student > Bachelor | 38 | 10% |
| Student > Master | 31 | 8% |
| Other | 24 | 6% |
| Other | 62 | 17% |
| Unknown | 81 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 104 | 28% |
| Biochemistry, Genetics and Molecular Biology | 79 | 21% |
| Agricultural and Biological Sciences | 52 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 3% |
| Computer Science | 7 | 2% |
| Other | 25 | 7% |
| Unknown | 94 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 117. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2022.
All research outputs
#364,352
of 25,775,807 outputs
Outputs from Nature Communications
#5,703
of 58,407 outputs
Outputs of similar age
#3,758
of 276,939 outputs
Outputs of similar age from Nature Communications
#51
of 789 outputs
Altmetric has tracked 25,775,807 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,407 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,939 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 789 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.