| Title |
Kinetics of human brown adipose tissue activation and deactivation
|
|---|---|
| Published in |
International Journal of Obesity, May 2018
|
| DOI | 10.1038/s41366-018-0104-3 |
| Pubmed ID | |
| Authors |
Brooks P. Leitner, Lauren S. Weiner, Matthew Desir, Peter A. Kahn, Daryl J. Selen, Cathy Tsang, Gerald M. Kolodny, Aaron M. Cypess |
| Abstract |
Brown adipose tissue (BAT) has been identified as a potential target in the treatment and prevention of obesity and metabolic disease. The precise kinetics of BAT activation and the duration of stimulus required to recruit metabolically active BAT, and its subsequent deactivation, are not well-understood. In this clinical trial, 19 healthy adults (BMI: 23.7 ± 0.7 kg/m2, Age: 31.2 ± 2.8 year, 12 female) underwent three different cooling procedures to stimulate BAT glucose uptake, and active BAT volume was determined using 18F-Fluorodeoxyglucose (FDG) PET/CT imaging. We found that 20 min of pre-injection cooling produces activation similar to the standard 60 min (39.9 mL vs. 44.2 mL, p = 0.52), indicating that BAT activity approaches its peak function soon after the initiation of cooling. Furthermore, upon removal of cold exposure, active BAT volume declines (13.6 mL vs. 44.2 mL, p = 0.002), but the deactivation process persists even hours following cessation of cooling. Thus, the kinetics of human BAT thermogenesis are characterized by a rapid increase soon after cold stimulation but a more gradual decline after rewarming. These characteristics reinforce the feasibility of developing mild, short-duration cold exposure to activate BAT and treat obesity and metabolic disease. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 67 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 19% |
| Student > Master | 9 | 13% |
| Student > Doctoral Student | 8 | 12% |
| Student > Bachelor | 7 | 10% |
| Professor > Associate Professor | 3 | 4% |
| Other | 8 | 12% |
| Unknown | 19 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 18% |
| Biochemistry, Genetics and Molecular Biology | 10 | 15% |
| Sports and Recreations | 7 | 10% |
| Agricultural and Biological Sciences | 5 | 7% |
| Nursing and Health Professions | 3 | 4% |
| Other | 10 | 15% |
| Unknown | 20 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2019.
All research outputs
#15,522,480
of 23,070,218 outputs
Outputs from International Journal of Obesity
#3,642
of 4,336 outputs
Outputs of similar age
#210,169
of 330,346 outputs
Outputs of similar age from International Journal of Obesity
#53
of 70 outputs
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