| Title |
Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA
|
|---|---|
| Published in |
Nature Communications, April 2018
|
| DOI | 10.1038/s41467-018-03961-y |
| Pubmed ID | |
| Authors |
Hai Zemmour, David Planer, Judith Magenheim, Joshua Moss, Daniel Neiman, Dan Gilon, Amit Korach, Benjamin Glaser, Ruth Shemer, Giora Landesberg, Yuval Dor |
| Abstract |
Detection of cardiomyocyte death is crucial for the diagnosis and treatment of heart disease. Here we use comparative methylome analysis to identify genomic loci that are unmethylated specifically in cardiomyocytes, and develop these as biomarkers to quantify cardiomyocyte DNA in circulating cell-free DNA (cfDNA) derived from dying cells. Plasma of healthy individuals contains essentially no cardiomyocyte cfDNA, consistent with minimal cardiac turnover. Patients with acute ST-elevation myocardial infarction show a robust cardiac cfDNA signal that correlates with levels of troponin and creatine phosphokinase (CPK), including the expected elevation-decay dynamics following coronary angioplasty. Patients with sepsis have high cardiac cfDNA concentrations that strongly predict mortality, suggesting a major role of cardiomyocyte death in mortality from sepsis. A cfDNA biomarker for cardiomyocyte death may find utility in diagnosis and monitoring of cardiac pathologies and in the study of normal human cardiac physiology and development. |
X Demographics
The data shown below were collected from the profiles of 57 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 23 | 40% |
| Israel | 5 | 9% |
| India | 1 | 2% |
| Saudi Arabia | 1 | 2% |
| Colombia | 1 | 2% |
| Australia | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 24 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 36 | 63% |
| Scientists | 17 | 30% |
| Practitioners (doctors, other healthcare professionals) | 3 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 198 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 198 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 18% |
| Researcher | 31 | 16% |
| Student > Master | 20 | 10% |
| Other | 16 | 8% |
| Student > Bachelor | 13 | 7% |
| Other | 20 | 10% |
| Unknown | 63 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 52 | 26% |
| Medicine and Dentistry | 22 | 11% |
| Agricultural and Biological Sciences | 21 | 11% |
| Engineering | 9 | 5% |
| Immunology and Microbiology | 4 | 2% |
| Other | 18 | 9% |
| Unknown | 72 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 52. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2024.
All research outputs
#826,815
of 25,766,791 outputs
Outputs from Nature Communications
#13,882
of 58,374 outputs
Outputs of similar age
#18,031
of 341,001 outputs
Outputs of similar age from Nature Communications
#327
of 1,158 outputs
Altmetric has tracked 25,766,791 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,374 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,001 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 1,158 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.