| Title |
ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled
|
|---|---|
| Published in |
Nature Communications, March 2015
|
| DOI | 10.1038/ncomms7666 |
| Pubmed ID | |
| Authors |
Koichi Miyatake, Morioh Kusakabe, Chika Takahashi, Eisuke Nishida |
| Abstract |
Cilia are essential for embryogenesis and maintenance of homeostasis, but little is known about the signalling pathways that regulate ciliogenesis. Here, we identify ERK7, an atypical mitogen-activated protein kinase, as a key regulator of ciliogenesis. ERK7 is strongly expressed in ciliated tissues of Xenopus embryos. ERK7 knockdown markedly diminishes both the number and the length of cilia in multiciliated cells, and it inhibits the apical migration of basal bodies. Moreover, ERK7 knockdown results in a loss of the apical actin meshwork, which is required for the proper migration of basal bodies. We find that the actin regulator CapZIP, which has been shown to regulate ciliogenesis in a phosphorylation-dependent manner, is an ERK7 substrate, and that Dishevelled, which has also been shown to regulate ciliogenesis, facilitates ERK7 phosphorylation of CapZIP through binding to both ERK7 and CapZIP. Collectively, these results identify an ERK7/Dishevelled/CapZIP axis that regulates ciliogenesis. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Unknown | 43 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 32% |
| Student > Ph. D. Student | 8 | 18% |
| Student > Master | 6 | 14% |
| Student > Bachelor | 3 | 7% |
| Professor | 2 | 5% |
| Other | 4 | 9% |
| Unknown | 7 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 39% |
| Biochemistry, Genetics and Molecular Biology | 14 | 32% |
| Neuroscience | 3 | 7% |
| Arts and Humanities | 1 | 2% |
| Nursing and Health Professions | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 7 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2015.
All research outputs
#6,416,268
of 22,797,621 outputs
Outputs from Nature Communications
#34,859
of 46,927 outputs
Outputs of similar age
#76,300
of 264,714 outputs
Outputs of similar age from Nature Communications
#510
of 795 outputs
Altmetric has tracked 22,797,621 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
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