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DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway

Overview of attention for article published in Oncogene, September 2004
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

patent
4 patents

Citations

dimensions_citation
412 Dimensions

Readers on

mendeley
235 Mendeley
Title
DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway
Published in
Oncogene, September 2004
DOI 10.1038/sj.onc.1207892
Pubmed ID
Authors

Atsushi Niida, Takatoshi Hiroko, Mana Kasai, Yoichi Furukawa, Yusuke Nakamura, Yutaka Suzuki, Sumio Sugano, Tetsu Akiyama

Abstract

Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the beta-catenin/TCF transcription complex and consequent regulation of a set of downstream genes. TCF-binding elements have been found in the promoter regions of many TCF target genes and characterized by a highly conserved consensus sequence. Utilizing this consensus sequence, we performed an in silico screening for new TCF target genes. Through computational screening and subsequent experimental analysis, we identified a novel TCF target gene, DKK1, which has been shown to be a potent inhibitor of Wnt signaling. Our finding suggests the existence of a novel feedback loop in Wnt signaling.

Mendeley readers

The data shown below were compiled from readership statistics for 235 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 2%
Portugal 1 <1%
Unknown 229 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 67 29%
Researcher 38 16%
Student > Master 32 14%
Student > Bachelor 26 11%
Student > Doctoral Student 14 6%
Other 37 16%
Unknown 21 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 75 32%
Biochemistry, Genetics and Molecular Biology 71 30%
Medicine and Dentistry 29 12%
Engineering 9 4%
Pharmacology, Toxicology and Pharmaceutical Science 4 2%
Other 17 7%
Unknown 30 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2021.
All research outputs
#3,964,081
of 19,579,367 outputs
Outputs from Oncogene
#2,014
of 9,942 outputs
Outputs of similar age
#62,326
of 311,072 outputs
Outputs of similar age from Oncogene
#13
of 99 outputs
Altmetric has tracked 19,579,367 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,942 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,072 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.