| Title |
DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway
|
|---|---|
| Published in |
Oncogene, September 2004
|
| DOI | 10.1038/sj.onc.1207892 |
| Pubmed ID | |
| Authors |
Atsushi Niida, Takatoshi Hiroko, Mana Kasai, Yoichi Furukawa, Yusuke Nakamura, Yutaka Suzuki, Sumio Sugano, Tetsu Akiyama |
| Abstract |
Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the beta-catenin/TCF transcription complex and consequent regulation of a set of downstream genes. TCF-binding elements have been found in the promoter regions of many TCF target genes and characterized by a highly conserved consensus sequence. Utilizing this consensus sequence, we performed an in silico screening for new TCF target genes. Through computational screening and subsequent experimental analysis, we identified a novel TCF target gene, DKK1, which has been shown to be a potent inhibitor of Wnt signaling. Our finding suggests the existence of a novel feedback loop in Wnt signaling. |
Mendeley readers
The data shown below were compiled from readership statistics for 285 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| Portugal | 1 | <1% |
| Unknown | 279 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 70 | 25% |
| Researcher | 40 | 14% |
| Student > Master | 35 | 12% |
| Student > Bachelor | 35 | 12% |
| Student > Doctoral Student | 15 | 5% |
| Other | 41 | 14% |
| Unknown | 49 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 85 | 30% |
| Agricultural and Biological Sciences | 78 | 27% |
| Medicine and Dentistry | 31 | 11% |
| Engineering | 10 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 1% |
| Other | 17 | 6% |
| Unknown | 60 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2023.
All research outputs
#3,310,984
of 23,006,268 outputs
Outputs from Oncogene
#1,345
of 10,676 outputs
Outputs of similar age
#5,708
of 60,852 outputs
Outputs of similar age from Oncogene
#12
of 129 outputs
Altmetric has tracked 23,006,268 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,676 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 60,852 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.