Title |
The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models
|
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Published in |
Arthritis Research & Therapy, November 2004
|
DOI | 10.1186/ar1478 |
Pubmed ID | |
Authors |
Erik Lubberts, Marije I Koenders, Wim B van den Berg |
Abstract |
Interleukin-17 (IL-17) is a T cell cytokine spontaneously produced by cultures of rheumatoid arthritis (RA) synovial membranes. High levels have been detected in the synovial fluid of patients with RA. The trigger for IL-17 is not fully identified; however, IL-23 promotes the production of IL-17 and a strong correlation between IL-15 and IL-17 levels in synovial fluid has been observed. IL-17 is a potent inducer of various cytokines such as tumor necrosis factor (TNF)-alpha, IL-1, and receptor activator of NF-kappaB ligand (RANKL). Additive or even synergistic effects with IL-1 and TNF-alpha in inducing cytokine expression and joint damage have been shown in vitro and in vivo. This review describes the role of IL-17 in the pathogenesis of destructive arthritis with a major focus on studies in vivo in arthritis models. From these studies in vivo it can be concluded that IL-17 becomes significant when T cells are a major element of the arthritis process. Moreover, IL-17 has the capacity to induce joint destruction in an IL-1-independent manner and can bypass TNF-dependent arthritis. Anti-IL-17 cytokine therapy is of interest as an additional new anti-rheumatic strategy for RA, in particular in situations in which elevated IL-17 might attenuate the response to anti-TNF/anti-IL-1 therapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 2 | 1% |
Mexico | 2 | 1% |
United Kingdom | 2 | 1% |
Netherlands | 1 | <1% |
Ireland | 1 | <1% |
India | 1 | <1% |
Canada | 1 | <1% |
Portugal | 1 | <1% |
Singapore | 1 | <1% |
Other | 3 | 2% |
Unknown | 166 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 35 | 19% |
Student > Ph. D. Student | 34 | 19% |
Student > Master | 31 | 17% |
Student > Bachelor | 22 | 12% |
Professor | 7 | 4% |
Other | 23 | 13% |
Unknown | 29 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 57 | 31% |
Medicine and Dentistry | 43 | 24% |
Biochemistry, Genetics and Molecular Biology | 17 | 9% |
Immunology and Microbiology | 14 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 4% |
Other | 11 | 6% |
Unknown | 31 | 17% |