| Title |
A stepwise epigenetic process controls immunoglobulin allelic exclusion
|
|---|---|
| Published in |
Nature Reviews Immunology, October 2004
|
| DOI | 10.1038/nri1458 |
| Pubmed ID | |
| Authors |
Yehudit Bergman, Howard Cedar |
| Abstract |
During the differentiation of T and B cells, immune-receptor loci in the genome must be made sterically accessible so that they can undergo rearrangement. Here, we discuss how this is carried out by the stepwise removal of epigenetic repression mechanisms - such as later-replication timing, heterochromatization, histone hypo-acetylation and DNA methylation - in a manner that initially favours one allele in each cell. We propose that this mechanism of allelic exclusion might also be the basis for the generation of gene diversity in other systems. |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Netherlands | 1 | 1% |
| Portugal | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 83 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 22% |
| Student > Bachelor | 12 | 14% |
| Researcher | 12 | 14% |
| Professor | 10 | 11% |
| Professor > Associate Professor | 10 | 11% |
| Other | 12 | 14% |
| Unknown | 13 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 50% |
| Medicine and Dentistry | 12 | 14% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Immunology and Microbiology | 2 | 2% |
| Engineering | 2 | 2% |
| Other | 5 | 6% |
| Unknown | 16 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2020.
All research outputs
#7,451,284
of 22,780,967 outputs
Outputs from Nature Reviews Immunology
#1,803
of 2,476 outputs
Outputs of similar age
#19,776
of 61,122 outputs
Outputs of similar age from Nature Reviews Immunology
#14
of 18 outputs
Altmetric has tracked 22,780,967 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,476 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.2. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.