Title |
Effects of resistance exercise on endothelial progenitor cell mobilization in women
|
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Published in |
Scientific Reports, December 2017
|
DOI | 10.1038/s41598-017-18156-6 |
Pubmed ID | |
Authors |
Fernando Ribeiro, Ilda P. Ribeiro, Ana C. Gonçalves, Alberto J. Alves, Elsa Melo, Raquel Fernandes, Rui Costa, Ana B. Sarmento-Ribeiro, José A. Duarte, Isabel M. Carreira, Sarah Witkowski, José Oliveira |
Abstract |
This study aimed to determine the effect of a single bout of resistance exercise at different intensities on the mobilization of circulating EPCs over 24 hours in women. In addition, the angiogenic factors stromal cell-derived factor 1 (SDF-1α), vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1α) and erythropoietin (EPO) were measured as potential mechanisms for exercise-induced EPCs mobilization. Thirty-eight women performed a resistance exercise session at an intensity of 60% (n = 13), 70% (n = 12) or 80% (n = 13) of one repetition maximum. Each session was comprised of three sets of 12 repetitions of four exercises: bench press, dumbbell curl, dumbbell squat, and standing dumbbell upright row. Blood was sampled at baseline and immediately, 6 hours, and 24 hours post-exercise. Circulating EPC and levels of VEGF, HIF-1α and EPO were significantly higher after exercise (P < 0.05). The change in EPCs from baseline was greatest in the 80% group (P < 0.05), reaching the highest at 6 hours post-exercise. The change in EPCs from baseline to 6 hours post-exercise was correlated with the change in VEGF (r = 0.492, P = 0.002) and HIF-1α (r = 0.388, P = 0.016). In general, a dose-response relationship was observed, with the highest exercise intensities promoting the highest increases in EPCs and angiogenic factors. |
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United Kingdom | 2 | 18% |
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Germany | 1 | 9% |
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Demographic breakdown
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Scientists | 4 | 36% |
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Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
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Unknown | 71 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 14% |
Researcher | 8 | 11% |
Student > Bachelor | 8 | 11% |
Student > Master | 7 | 10% |
Professor | 5 | 7% |
Other | 10 | 14% |
Unknown | 23 | 32% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 8 | 11% |
Nursing and Health Professions | 7 | 10% |
Psychology | 2 | 3% |
Other | 6 | 8% |
Unknown | 27 | 38% |