| Title |
Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions
|
|---|---|
| Published in |
Nature Chemistry, November 2017
|
| DOI | 10.1038/nchem.2878 |
| Pubmed ID | |
| Authors |
Clémentine Gibard, Subhendu Bhowmik, Megha Karki, Eun-Kyong Kim, Ramanarayanan Krishnamurthy |
| Abstract |
Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had limited success and/or require unique environments that are incompatible with subsequent generation of the corresponding oligomers or higher-order structures. Here, we demonstrate that diamidophosphate (DAP)-a plausible prebiotic agent produced from trimetaphosphate-efficiently (amido)phosphorylates a wide variety of (pre)biological building blocks (nucleosides/tides, amino acids and lipid precursors) under aqueous (solution/paste) conditions, without the need for a condensing agent. Significantly, higher-order structures (oligonucleotides, peptides and liposomes) are formed under the same phosphorylation reaction conditions. This plausible prebiotic phosphorylation process under similar reaction conditions could enable the systems chemistry of the three classes of (pre)biologically relevant molecules and their oligomers, in a single-pot aqueous environment. |
X Demographics
The data shown below were collected from the profiles of 59 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 14% |
| United Kingdom | 6 | 10% |
| Mexico | 3 | 5% |
| Canada | 3 | 5% |
| India | 2 | 3% |
| Germany | 2 | 3% |
| Venezuela, Bolivarian Republic of | 2 | 3% |
| Japan | 2 | 3% |
| Finland | 1 | 2% |
| Other | 6 | 10% |
| Unknown | 24 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 41 | 69% |
| Scientists | 14 | 24% |
| Practitioners (doctors, other healthcare professionals) | 2 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
| Unknown | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 252 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 252 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 55 | 22% |
| Researcher | 42 | 17% |
| Student > Bachelor | 30 | 12% |
| Student > Master | 29 | 12% |
| Student > Doctoral Student | 20 | 8% |
| Other | 35 | 14% |
| Unknown | 41 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 106 | 42% |
| Biochemistry, Genetics and Molecular Biology | 31 | 12% |
| Agricultural and Biological Sciences | 23 | 9% |
| Earth and Planetary Sciences | 11 | 4% |
| Physics and Astronomy | 8 | 3% |
| Other | 21 | 8% |
| Unknown | 52 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 371. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2023.
All research outputs
#86,541
of 25,756,911 outputs
Outputs from Nature Chemistry
#24
of 3,385 outputs
Outputs of similar age
#1,889
of 343,488 outputs
Outputs of similar age from Nature Chemistry
#1
of 51 outputs
Altmetric has tracked 25,756,911 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,385 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.9. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.