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Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions

Overview of attention for article published in Nature Chemistry, November 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#12 of 2,189)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Citations

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36 Dimensions

Readers on

mendeley
145 Mendeley
Title
Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions
Published in
Nature Chemistry, November 2017
DOI 10.1038/nchem.2878
Pubmed ID
Authors

Clémentine Gibard, Subhendu Bhowmik, Megha Karki, Eun-Kyong Kim, Ramanarayanan Krishnamurthy

Abstract

Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had limited success and/or require unique environments that are incompatible with subsequent generation of the corresponding oligomers or higher-order structures. Here, we demonstrate that diamidophosphate (DAP)-a plausible prebiotic agent produced from trimetaphosphate-efficiently (amido)phosphorylates a wide variety of (pre)biological building blocks (nucleosides/tides, amino acids and lipid precursors) under aqueous (solution/paste) conditions, without the need for a condensing agent. Significantly, higher-order structures (oligonucleotides, peptides and liposomes) are formed under the same phosphorylation reaction conditions. This plausible prebiotic phosphorylation process under similar reaction conditions could enable the systems chemistry of the three classes of (pre)biologically relevant molecules and their oligomers, in a single-pot aqueous environment.

Twitter Demographics

The data shown below were collected from the profiles of 72 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 145 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 22%
Researcher 30 21%
Student > Master 17 12%
Student > Bachelor 15 10%
Unspecified 14 10%
Other 36 25%
Unknown 1 <1%
Readers by discipline Count As %
Chemistry 63 43%
Unspecified 22 15%
Agricultural and Biological Sciences 19 13%
Biochemistry, Genetics and Molecular Biology 17 12%
Earth and Planetary Sciences 8 6%
Other 15 10%
Unknown 1 <1%

Attention Score in Context

This research output has an Altmetric Attention Score of 339. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2019.
All research outputs
#32,972
of 13,377,713 outputs
Outputs from Nature Chemistry
#12
of 2,189 outputs
Outputs of similar age
#1,820
of 312,740 outputs
Outputs of similar age from Nature Chemistry
#1
of 63 outputs
Altmetric has tracked 13,377,713 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,189 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,740 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.