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Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions

Overview of attention for article published in Nature Chemistry, November 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#15 of 2,434)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Citations

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61 Dimensions

Readers on

mendeley
188 Mendeley
Title
Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions
Published in
Nature Chemistry, November 2017
DOI 10.1038/nchem.2878
Pubmed ID
Authors

Clémentine Gibard, Subhendu Bhowmik, Megha Karki, Eun-Kyong Kim, Ramanarayanan Krishnamurthy

Abstract

Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had limited success and/or require unique environments that are incompatible with subsequent generation of the corresponding oligomers or higher-order structures. Here, we demonstrate that diamidophosphate (DAP)-a plausible prebiotic agent produced from trimetaphosphate-efficiently (amido)phosphorylates a wide variety of (pre)biological building blocks (nucleosides/tides, amino acids and lipid precursors) under aqueous (solution/paste) conditions, without the need for a condensing agent. Significantly, higher-order structures (oligonucleotides, peptides and liposomes) are formed under the same phosphorylation reaction conditions. This plausible prebiotic phosphorylation process under similar reaction conditions could enable the systems chemistry of the three classes of (pre)biologically relevant molecules and their oligomers, in a single-pot aqueous environment.

Twitter Demographics

The data shown below were collected from the profiles of 69 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 188 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 188 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 44 23%
Researcher 31 16%
Student > Master 22 12%
Student > Bachelor 21 11%
Student > Doctoral Student 17 9%
Other 30 16%
Unknown 23 12%
Readers by discipline Count As %
Chemistry 81 43%
Agricultural and Biological Sciences 21 11%
Biochemistry, Genetics and Molecular Biology 21 11%
Earth and Planetary Sciences 9 5%
Physics and Astronomy 8 4%
Other 15 8%
Unknown 33 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 345. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2020.
All research outputs
#44,328
of 15,887,811 outputs
Outputs from Nature Chemistry
#15
of 2,434 outputs
Outputs of similar age
#1,928
of 323,736 outputs
Outputs of similar age from Nature Chemistry
#1
of 63 outputs
Altmetric has tracked 15,887,811 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,434 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,736 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.