| Title |
Human tissue-engineered blood vessels for adult arterial revascularization
|
|---|---|
| Published in |
Nature Medicine, February 2006
|
| DOI | 10.1038/nm1364 |
| Pubmed ID | |
| Authors |
Nicolas L'Heureux, Nathalie Dusserre, Gerhardt Konig, Braden Victor, Paul Keire, Thomas N Wight, Nicolas A F Chronos, Andrew E Kyles, Clare R Gregory, Grant Hoyt, Robert C Robbins, Todd N McAllister |
| Abstract |
There is a crucial need for alternatives to native vein or artery for vascular surgery. The clinical efficacy of synthetic, allogeneic or xenogeneic vessels has been limited by thrombosis, rejection, chronic inflammation and poor mechanical properties. Using adult human fibroblasts extracted from skin biopsies harvested from individuals with advanced cardiovascular disease, we constructed tissue-engineered blood vessels (TEBVs) that serve as arterial bypass grafts in long-term animal models. These TEBVs have mechanical properties similar to human blood vessels, without relying upon synthetic or exogenous scaffolding. The TEBVs are antithrombogenic and mechanically stable for 8 months in vivo. Histological analysis showed complete tissue integration and formation of vasa vasorum. The endothelium was confluent and positive for von Willebrand factor. A smooth muscle-specific alpha-actin-positive cell population developed within the TEBV, suggesting regeneration of a vascular media. Electron microscopy showed an endothelial basement membrane, elastogenesis and a complex collagen network. These results indicate that a completely biological and clinically relevant TEBV can be assembled exclusively from an individual's own cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 598 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 1% |
| United Kingdom | 5 | <1% |
| Poland | 2 | <1% |
| Switzerland | 2 | <1% |
| Japan | 2 | <1% |
| Brazil | 1 | <1% |
| Singapore | 1 | <1% |
| Spain | 1 | <1% |
| Germany | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 573 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 145 | 24% |
| Student > Master | 95 | 16% |
| Researcher | 92 | 15% |
| Student > Bachelor | 58 | 10% |
| Student > Doctoral Student | 39 | 7% |
| Other | 94 | 16% |
| Unknown | 75 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 169 | 28% |
| Agricultural and Biological Sciences | 104 | 17% |
| Medicine and Dentistry | 79 | 13% |
| Biochemistry, Genetics and Molecular Biology | 48 | 8% |
| Materials Science | 40 | 7% |
| Other | 50 | 8% |
| Unknown | 108 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 48. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2024.
All research outputs
#825,487
of 24,495,755 outputs
Outputs from Nature Medicine
#2,151
of 8,990 outputs
Outputs of similar age
#1,153
of 74,926 outputs
Outputs of similar age from Nature Medicine
#4
of 54 outputs
Altmetric has tracked 24,495,755 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,990 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 104.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 74,926 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.