| Title |
The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro
|
|---|---|
| Published in |
Scientific Reports, July 2017
|
| DOI | 10.1038/s41598-017-05407-9 |
| Pubmed ID | |
| Authors |
Jose A. Morales-García, Mario de la Fuente Revenga, Sandra Alonso-Gil, María Isabel Rodríguez-Franco, Amanda Feilding, Ana Perez-Castillo, Jordi Riba |
| Abstract |
Banisteriopsis caapi is the basic ingredient of ayahuasca, a psychotropic plant tea used in the Amazon for ritual and medicinal purposes, and by interested individuals worldwide. Animal studies and recent clinical research suggests that B. caapi preparations show antidepressant activity, a therapeutic effect that has been linked to hippocampal neurogenesis. Here we report that harmine, tetrahydroharmine and harmaline, the three main alkaloids present in B. caapi, and the harmine metabolite harmol, stimulate adult neurogenesis in vitro. In neurospheres prepared from progenitor cells obtained from the subventricular and the subgranular zones of adult mice brains, all compounds stimulated neural stem cell proliferation, migration, and differentiation into adult neurons. These findings suggest that modulation of brain plasticity could be a major contribution to the antidepressant effects of ayahuasca. They also expand the potential application of B. caapi alkaloids to other brain disorders that may benefit from stimulation of endogenous neural precursor niches. |
X Demographics
The data shown below were collected from the profiles of 58 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 17% |
| Spain | 9 | 16% |
| Canada | 3 | 5% |
| Sweden | 2 | 3% |
| United Kingdom | 2 | 3% |
| Mexico | 2 | 3% |
| Netherlands | 2 | 3% |
| Costa Rica | 1 | 2% |
| Argentina | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 25 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 53 | 91% |
| Practitioners (doctors, other healthcare professionals) | 3 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
| Scientists | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 301 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 301 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 62 | 21% |
| Student > Master | 47 | 16% |
| Student > Ph. D. Student | 30 | 10% |
| Researcher | 29 | 10% |
| Student > Doctoral Student | 15 | 5% |
| Other | 28 | 9% |
| Unknown | 90 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 35 | 12% |
| Neuroscience | 34 | 11% |
| Medicine and Dentistry | 29 | 10% |
| Psychology | 25 | 8% |
| Biochemistry, Genetics and Molecular Biology | 23 | 8% |
| Other | 57 | 19% |
| Unknown | 98 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 248. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2023.
All research outputs
#151,774
of 25,660,026 outputs
Outputs from Scientific Reports
#1,851
of 142,354 outputs
Outputs of similar age
#3,179
of 325,396 outputs
Outputs of similar age from Scientific Reports
#57
of 5,421 outputs
Altmetric has tracked 25,660,026 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 142,354 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.8. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 5,421 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.